C.H. Lee

ORCID: 0000-0003-3310-9662
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About
Contact & Profiles
Research Areas
  • Bioinformatics and Genomic Networks
  • Gene Regulatory Network Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer, Hypoxia, and Metabolism
  • Enzyme Structure and Function
  • Genomics and Phylogenetic Studies
  • Machine Learning in Bioinformatics
  • Mathematical Biology Tumor Growth
  • Metabolomics and Mass Spectrometry Studies

University of Oxford
2024

Deregulated metabolism is one of the hallmarks cancer. It well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen available and mitochondrial respiration functional. However, lower energy efficiency aerobic with respect makes this behaviour, namely Warburg effect, counter-intuitive, although it has now been recognized as source anabolic precursors. On other hand, there evidence oxygenated could be fuelled by exogenous lactate produced from glycolysis. We...

10.1371/journal.pcbi.1011944 article EN cc-by PLoS Computational Biology 2024-03-15
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