A5046698467- interferon and immune responses
- RNA regulation and disease
- RNA Research and Splicing
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
Columbia University
2025
Columbia University Irving Medical Center
2023-2024
Drew University
2018
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly understood. Viral double-stranded (dsRNA) triggers innate immune responses when sensed by host pattern recognition receptors (PRRs) present in all cell types. Here, we report human neurons intrinsically carry exceptionally high levels immunostimulatory dsRNAs identify long 3'UTRs as giving rise to neuronal dsRNA structures....
Summary Ku70 and Ku80 form Ku, a ring-shaped protein that initiates the non-homologous end-joining (NHEJ) DNA repair pathway. 1 Specifically, Ku binds to double-stranded (dsDNA) ends recruits other NHEJ factors ( e.g. , DNA-PKcs LIG4). While RNA (dsRNA) 2 traps mutated-DNA-PKcs on ribosomal in vivo, 3,4 physiological significance of Ku-dsRNA interactions otherwise wild-type cells remains elusive. Intriguingly, while dispensable for murine development, 5,6 is essential human cells. 7 Despite...