A5014741350- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Light effects on plants
- Plant Parasitism and Resistance
- Photosynthetic Processes and Mechanisms
- Plant-Microbe Interactions and Immunity
- Plant nutrient uptake and metabolism
- Plant Reproductive Biology
- Ubiquitin and proteasome pathways
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Insect-Plant Interactions and Control
- Plant and animal studies
- Seed Germination and Physiology
- Plant tissue culture and regeneration
- Plant Micronutrient Interactions and Effects
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Aluminum toxicity and tolerance in plants and animals
- Allelopathy and phytotoxic interactions
- Plant responses to water stress
- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Anesthesia and Sedative Agents
Yunnan University
2020-2025
Chongqing Medical University
2024-2025
Second Affiliated Hospital of Chongqing Medical University
2024-2025
Dalian Medical University
2024-2025
Xishuangbanna Tropical Botanical Garden
2013-2020
Chinese Academy of Sciences
2020
University of Chinese Academy of Sciences
2013-2018
Hefei Urban Planning & Design Institute
2009
Emory University
2004-2007
SNF 1-RELATED PROTEIN KINASE 2 (SnRK2) is a family of plant-specific protein kinases which the key regulator hyper-osmotic stress signalling and abscisic acid (ABA)-dependent development in various plants. Among rice subclass-I -II SnRK2s, osmotic stress/ABA–activated kinase (SAPK2) may be primary mediator ABA signaling. However, SAPK2 has not been comprehensively characterized. In this study, we elucidated functional properties using loss-of-function mutants produced with CRISPR/Cas9...
The WRKY transcription factors have been demonstrated to play crucial roles in regulating stress responses; however, the exact mechanisms underlying their involvement responses are not fully understood. Arabidopsis WRKY8 was predominantly expressed roots and highly upregulated by salt treatment. Disruption of rendered plants hypersensitive salt, showing delayed germination, inhibited post-germination development accelerated chlorosis. Further investigation revealed that interacted with VQ9,...
The fragile X mental retardation protein (FMRP) is a selective RNA-binding implicated in regulating translation of its mRNA ligands. absence FMRP results syndrome, one the leading causes inherited retardation. Delayed dendritic spine maturation was found patients as well Fmr1 knockout (KO) mice, indicating functional requirement synaptic development. However, biochemical link between deficiency and neuronal impairment during brain development has not been defined. How governs normal synapse...
Abstract Gibberellin (GA) and photoperiod pathways have recently been demonstrated to collaboratively modulate flowering under long days (LDs). However, the molecular mechanisms underlying this collaboration remain largely unclear. In study, we found that GA-induced expression of FLOWERING LOCUS T (FT) LDs was dependent on CONSTANS (CO), a critical transcription factor positively involved in signaling. Mechanistic investigation revealed DELLA proteins, group crucial repressors GA signaling,...
Abscisic acid (ABA) is known to suppress seed germination and post-germinative growth of Arabidopsis (Arabidopsis thaliana), jasmonate (JA) enhances ABA function. However, the molecular mechanism underlying crosstalk between JA signaling pathways remains largely elusive. Here, we show that exogenous coronatine, a analog structurally similar active conjugate jasmonate-isoleucine, significantly delayed response ABA. Disruption receptor CORONATINE INSENSITIVE1 or accumulation repressor...
Abstract Seed germination, an important developmental stage in the life cycle of seed plants, is regulated by complex signals. Melatonin a signaling molecule associated with germination under stressful conditions, although underlying regulatory mechanisms are largely unknown. In this study, we showed that low concentration (10 µM or 100 µM) melatonin had no effect on but when increased to 500 1000 µM, was significantly inhibited Arabidopsis. RNA sequencing analysis correlated phytohormones...
The sucrose non-fermenting-1-related protein kinase 2 family (SnRK2s) unifies different abiotic stress signals in plants. To date, the functions of two rice SnRK2s, osmotic stress/ABA-activated 1 (SAPK1) and SAPK2, have been unknown. We investigated their roles response to salt by generating loss-of-function lines using CRISPR/Cas9 system overexpressing these proteins transgenic Expression profiling revealed that SAPK1 SAPK2 expression were strongly induced drought, NaCl, PEG treatment, but...
Coronavirus disease 2019 (COVID-19) affected people worldwide, and fever is one of the major symptoms this disease. Although Acetaminophen (APAP) a common fever-reducing medication, it can also mediate liver injury. However, role PGC-1α in regulating mitochondrial quality control by lactate dehydrogenase B (LDHB), vital enzyme catalyzing conversion to pyruvate, APAP-induced hepatotoxicity, unclear. Here, gene expression omnibus data patients with injury were used explore profiles. AML12...
ABSTRACT The heading date of rice is a crucial agronomic characteristic that influences its adaptability to different regions and productivity potential. Despite the involvement WRKY transcription factors in various biological processes related development, precise mechanisms through which these regulate have not been well elucidated. present study identified OsWRKY11 as factor exhibits pivotal function regulation comprehensive screening clustered regularly interspaced palindromic repeats...
Seed germination and early seedling establishment, critical developmental stages in the life cycle of seed plants, are modulated by diverse endogenous hormones surrounding environment. Arabidopsis ABSCISIC ACID-INSENSITIVE5 (ABI5) is a central transcription factor abscisic acid (ABA) signaling that represses those processes. ABI5 precisely at post-translational level; however, whether it interacts with other crucial transcriptional regulators remains to be investigated. In this study, VQ18...
Abstract WRKY12 and WRKY13 are two WRKY transcription factors that play important roles in the control of flowering time under short‐day (SD) conditions. The temporally regulated expression indicates they may be involved age‐mediated pathway. However, their this pathway poorly understood. Here, we show is directly by SQUAMOSA PROMOTER BINDING–LIKE 10 (SPL10), a factor downstream age Binding activation analyses revealed SPL10 functions as positive regulator negative . Further mechanistic...
Arabidopsis VQ motif-containing proteins have recently been demonstrated to interact with several WRKY transcription factors; however, their specific biological functions and the molecular mechanisms underlying involvement in defense responses remain largely unclear. Here, we showed that two genes, VQ12 VQ29, were highly responsive necrotrophic fungal pathogen Botrytis cinerea. To characterize roles plant defense, generated amiR-vq12 transgenic plants by using an artificial miRNA approach...
Abstract Recent studies in Arabidopsis have revealed that some VQ motif‐containing proteins physically interact with WRKY transcription factors; however, their specific biological functions are still poorly understood. In this study, we confirmed the interaction between VQ10 and WRKY8, show WRKY8 formed a complex plant cell nucleus. Yeast two‐hybrid analysis showed middle region of motif critical for interaction, promotes DNA‐binding activity WRKY8. Further investigation protein was...
The fragile X mental retardation protein (FMRP) is a selective RNA-binding that regulates translation and plays essential roles in synaptic function. FMRP bound to specific mRNA ligands, actively transported into neuronal processes microtubule-dependent manner, associated with polyribosomes engaged elongation. However, the biochemical relationship between FMRP-microtubule association FMRP-polyribosome remains elusive. Here, we report although majority of incorporated elongating soluble...
Summary Drought constitutes a significant environmental factor influencing the growth and development of plants. Consequently, terrestrial plants have evolved range strategies to mitigate adverse effects soil water deficit. One such strategy, known as drought escape, involves acceleration flowering under drought, thereby enabling complete their life cycle rapidly. However, molecular mechanisms underlying this adaptive response remain largely unclear. Using genetic, molecular, biochemical...
Propofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, propofol derivative, also targets GABAA receptors with enhanced potency. Regarding chronopharmacology, it remains unclear whether the new drug ciprofol has improved effect and less side effects compared propofol. First, we assessed critical dosage (Dca) of exhibited diurnal rhythmicity. At highest Dca, loss righting reflex duration was significantly longer for than that at both Zeitgeber Time (ZT) 4...
Gibberellin (GA) regulates many developmental transitions in the plant life cycle. Although great progress has been made, GA signaling pathways have not fully elucidated. Identifying and characterizing new targets of DELLA proteins is an effective approach to reveal complicated networks. In this study, two novel DELLA-interacting transcription factors, bHLH48 bHLH60, were identified. Their overexpression caused plants flower early under long-day conditions, whereas their functional...