A5101738020- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Complement system in diseases
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Sarcoidosis and Beryllium Toxicity Research
- Lipid metabolism and disorders
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Kawasaki Disease and Coronary Complications
- Infective Endocarditis Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
Beijing Anzhen Hospital
2016-2025
Capital Medical University
2016-2025
Hangzhou Children's Hospital
2024
Nantong University
2024
Nanning Normal University
2024
The First People's Hospital of Changzhou
2020
Children's Hospital of Fudan University
2019
Beijing Institute of Water
2014-2018
Xi'an University of Technology
2007
Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte (NLR) have been reported to reflect the inflammatory response disease activity in a variety of autoimmune diseases.This study aimed evaluate value PLR NLR as markers monitor Takayasu's arteritis (TAK).A retrospective case-control involving 88 patients with TAK 78 healthy controls was performed. We compared between controls, also analysed correlations or indices activity.Increased were observed TAK. positively correlated...
Abstract Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) a hormone involved in the regulation of lipid metabolism and inflammation. However, relationship between ANGPTL8 TAD remains unknown. Methods This case-control study included 78 patients 72 controls. The diameter was evaluated computed tomography used to assess severity. Circulating levels were measured enzyme-linked immunosorbent assay. Associations with...
Mounting evidence has linked microbiome and metabolome to systemic autoimmunity cardiovascular diseases (CVDs). Takayasu arteritis (TAK) is a rare disease that shares features of immune-related inflammatory CVDs, about which there relatively limited information. This study was undertaken characterize gut microbial dysbiosis its crosstalk with phenotypes in TAK.To address the discriminatory signatures, we performed shotgun sequencing fecal metagenome across discovery cohort (n = 97) an...
Objective To explore the risk factors affecting peripherally inserted central catheter (PICC) tip malposition in preterm infants. Methods A retrospective collection of clinical data from infants who underwent PICC placement neonatal departments Guangxi Maternal and Child Health Hospital eight other hospitals January 2021 to April 2024 was conducted. The incidence analyzed. were divided into two groups based on occurrence malposition: group non-malposition group. Multifactorial logistic...
Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in patients crucial for uncovering cellular heterogeneity discovering potential therapeutic targets. This study utilized single-cell transcriptome analysis on aortic specimens from three patients, with control data sourced a publicly available database (GSE155468). Additionally, bulk RNA sequencing was performed...
3-Chalcogenylindoles serve as crucial building blocks in organic synthesis and pharmaceutical chemistry. Herein, we describe a simple general of 3-chalcogenylindoles through the direct C–H chalcogenation indoles using N-selenophthalimide N-sulfenylsuccinimide reagents presence CuBr2 catalyst. The reactions were carried out CH2Cl2 at room temperature under an air atmosphere with low loading catalyst, wide range 3-selenylindoles 3-thioindoles obtained good yields. Various functionalities,...
ABSTRACT This study developed a two-dimensional PCR (2D-PCR) method for simultaneous detection of nine sexually transmitted disease pathogens (STDPs) in cervical brush samples collected after human papillomavirus (HPV) screening, aiming to evaluate co-infection rates and epidemiological trends. The 2D-PCR assay was optimized under single-tube closed conditions, with sensitivity accuracy validated. prevalent STDPs were assessed 2,193 females undergoing routine gynecological inspections HPV...
Objective Depression is a common complication in Takayasu arteritis (TA). Disorders of the immune system play an important role both diseases. This study aimed to clarify feature cytokines TA patients with depression. Methods In this cross-sectional study, serum were tested 40 and 11 healthy controls using Bio-Plex Magpix System (Bio-Rad ® ). The state depression was measured by Zung Self-Rating Scale (SDS) patients. Logistic regression analysis performed find risk factors TA. Results had...
Objective: To analyze the clinical outcome of corticosteroid and/or immunosuppressive treatment preoperatively in patients with Takayasu's arteritis. Patients and Methods: Forty-six arteritis who received cardiovascular surgery between January 2010 December 2015 Beijing Anzhen Hospital were enrolled this study. Their characteristics, preoperative drug therapy, surgical treatment, pathological examination results retrospectively analyzed for effect drugs on surgery. Results: All 8 active...
Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu's arteritis (TAK). However, source IFN-γ TAK patients not fully clear. We aimed to investigate TAK. 60 and 35 health controls were enrolled. The lymphocyte subsets peripheral blood detected by flow cytometry, cytokines Bio-plex. correlation among subsets, disease activity indexes was analyzed person correlation. level serum significantly increased (P < 0.05). percentage CD3+IFN-γ+ cells CD3+ higher than that...
Abstract Aim Systemic lupus erythematosus (SLE) with severe coronary artery disease (CAD) is associated increased mortality. This study aimed to assess the characteristics and risk factors of CAD in SLE. Method multicenter, cross‐sectional enrolled consecutive patients SLE included Chinese Rheumatism Date Center registry. Patients including angiography‐confirmed stenosis ≥50% left main, ≥70% other major arteries, or myocardial infarction were classified into group. without control Subgroups...
Abstract Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation aneurysms in large vessel vasculitis is unknown. The aim this study to investigate clinical and laboratory features Takayasu arteritis (TAK) explore risk factors that aneurysm these patients. This retrospective compared manifestations, parameters, imaging results 103 TAK patients or without analyzed formation. 20.4% were found have...
Takayasu's arteritis (TAK) is a large-vessel vasculitis. Glucocorticoids (GCs) combined with cyclophosphamide (CTX) common treatment option, but their efficacy limited. The aim of this retrospective study was to the and safety tocilizumab (TCZ) in TAK.A total 63 patients TAK were divided into two groups according different strategies: 31 TCZ group 32 CTX group. After 6 months treatment, disease activity side effects evaluated compared between groups.After 3 National Institutes Health (NIH)...
To investigate the clinical characteristics and site of pulmonary involvement in Takayasu arteritis (TAK) patients with artery (PAI).We retrospectively investigated data 141 TAK patients. The image without PAI were analyzed compared. followed up. major outcome was all-cause mortality. minor exacerbation or new occurrence PAI, which leads to disease progression events.For considered, detected 65 (46.1%) had a significantly higher cumulative incidence events than those (P < 0.001). frequencies...
Background The implication of the monocyte-to-high-density lipoprotein ratio (MHR) in Takayasu arteritis (TAK) remains unclear. Objective We aimed to assess predictive value MHR identify coronary involvement with TAK and determine patient prognosis. Methods In this retrospective study, 1,184 consecutive patients were collected assessed, those who initially treated angiography enrolled classified according or no involvement. Binary logistic analysis was performed risk factors....
Takayasu arteritis (TAK) is a large-vessel vasculitis with high relapse rate. Longitudinal studies identifying risk factors of are limited. We aimed to analyze the associated and develop prediction model for relapse.We analyzed in prospective cohort 549 TAK patients from Chinese Registry Systemic Vasculitis between June 2014 December 2021 using univariate multivariate Cox regression analyses. also developed relapse, stratified into low-, medium-, high-risk groups. Discrimination calibration...
Accurate evaluation of the activity stage in Takayasu arteritis (TA) is important for revascularization TA with coronary artery involvement (TA-CAD). Here, we report case a patient mismatch systemic and local inflammatory activity, leading to 13 times need recurrent revascularization.A 31-year-old woman family history disease underwent percutaneous intervention (PCI) critical ostial lesions. This was identified Numano Type V she optimal medical therapy PCIs. Her clinical markers were quickly...