A5069814098- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Spinal Fractures and Fixation Techniques
- Radiopharmaceutical Chemistry and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- CAR-T cell therapy research
- Medical Imaging and Analysis
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neural Engineering
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Treatments and Mutations
- Synthesis and Biological Evaluation
- Photoacoustic and Ultrasonic Imaging
- Spine and Intervertebral Disc Pathology
- Diversity and Career in Medicine
- Cerebrospinal fluid and hydrocephalus
University of California, Los Angeles
2019-2024
UCLA Health
2021-2024
Kaiser Permanente
2023
Los Angeles Medical Center
2023
Neurological Surgery
2018-2023
Brigham and Women's Hospital
2017-2022
Harvard University
2017-2022
Northwestern University
2021
Oxford University Press (United Kingdom)
2020
Dana-Farber Brigham Cancer Center
2019
Abstract The successes of checkpoint blockade immunotherapy (CBI) and BRAFV600-targeted therapy trials have generated substantial promise for revolutionizing the management patients with advanced melanoma. However, because early clinical CBIs either excluded or included disproportionately fewer cases melanoma brain metastases (MBMs), survival benefit these novel therapies MBM remains unknown. We, therefore, evaluated characteristics, management, overall (OS) who presented cutaneous MBMs...
Focused ultrasound (FUS) has been under investigation for neurosurgical applications since the 1940s. Early experiments demonstrated as an effective tool creation of intracranial lesions; however, they were limited by need craniotomy to avoid trajectory damage and wave distortion skull, also lacked techniques monitoring. Since then, development hemispheric distribution phased arrays resolved issue skull allowed a completely transcranial procedure. Similarly, advances in MR technology have...
Abstract Purpose: The integrated histopathologic and molecular diagnoses of the 2016 WHO classification central nervous system tumors have revolutionized patient care by improving diagnostic accuracy reproducibility; however, frequency consequences misclassification histologically diagnosed diffuse gliomas are unknown. Experimental Design: Patients with newly ICD-O-3 (International Classification Diseases) encoded from 2010–2015 were identified National Cancer Database, rates overall...
MRI-guided focused ultrasound thalamotomy has been shown to be an effective treatment for medication refractory essential tremor. Here, we report a clinical-radiological analysis of 123 cases thalamotomy, and explore the relationships between parameters, lesion characteristics outcomes. All patients undergoing by single surgeon were included. The procedure was performed as previously described, followed up 1 year. MRI 24 h post-treatment, locations volumes calculated. We retrospectively...
OBJECTIVE Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy was recently approved for use in the treatment of medication-refractory essential tremor (ET). Previous work has described lesion appearance and volume on MRI up to 6 months after treatment. Here, authors report volumetric segmentation associated edema immediate postoperative period 1 year following treatment, relate these radiographic characteristics with clinical outcome. METHODS Seven patients ET underwent MRgFUS...
Loss of pituitary function due to nonfunctional adenoma (NFPA) may be compression the gland. It has been proposed that size gland and relative perioperative expansion relate recovery function, but extent this is unclear. This study aims assess temporal changes in hormonal after transsphenoidal resection NFPA relationship between reexpansion endocrine recovery.
Abstract Accurate brain meningioma segmentation and volumetric assessment are critical for serial patient follow-up, surgical planning monitoring response to treatment. Current gold standard of manual labeling is a time-consuming process, subject inter-user variability. Fully-automated algorithms have the potential bring analysis into clinical research workflows by increasing accuracy efficiency, reducing variability saving time. Previous has focused solely on tasks without impact usability...
Abstract Background Although surgery plays a crucial diagnostic role in World Health Organization (WHO) grade II 1p/19q-codeleted oligodendrogliomas, the of maximal tumor surgical resection remains unclear, with early retrospective series limited by lack molecular classification or appropriate control groups. Methods The characteristics, management, and overall survival (OS) patients ≥20 years old presenting histology-proven WHO oligodendrogliomas during 2010–2016 were evaluated using...
Although French psychiatrist-turned-neurosurgeon Jean Talairach (1911–2007) is perhaps best known for the stereotaxic atlas he produced with Pierre Tournoux and Gábor Szikla, has left his mark on most aspects of modern stereotactic functional neurosurgery. In field psychosurgery, expressed critique practice prefrontal lobotomy subsequently was first to describe more selective approach using bilateral anterior capsulotomy. Turning attention stereotaxy, spearheaded team at Hôpital Sainte-Anne...
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS that has been linked with defects in regulatory T cell function. Therefore, strategies to selectively target pathogenic cells via enhanced activity may provide therapeutic benefit. Kv1.3 a voltage-gated potassium channel expressed on myelin-reactive from MS patients. Kv1.3-knockout (KO) mice are protected experimental autoimmune encephalomyelitis, animal model MS, and Kv1.3-KO Th display suppressive capacity...
Deep brain stimulation (DBS) is traditionally performed on an awake patient with intraoperative recordings and test stimulation. DBS under general anesthesia MRI (iMRI) has demonstrated high target accuracy, reduced operative time, direct confirmation of placement, the ability to place electrodes without cessation medications. The authors describe their initial experience using iMRI perform asleep discuss procedural radiological outcomes this procedure.All were implanted by a single surgeon...