A5101604239- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Cancer Studies
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Radiopharmaceutical Chemistry and Applications
- Atrial Fibrillation Management and Outcomes
- Lung Cancer Research Studies
- Vascular Procedures and Complications
- Trigeminal Neuralgia and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Ocular Oncology and Treatments
- Tuberous Sclerosis Complex Research
University of Washington
2018-2025
Neurological Surgery
2018-2024
University of Washington Medical Center
2024
University of California, San Diego
2016-2021
Washington University in St. Louis
2021
University of Minnesota
2018
Moores Cancer Center
2017
Barrow Neurological Institute
2016
Milbank Memorial Fund
2012-2014
Brighton and Hove City Council
2004
OBJECTIVE Therapeutic options for brain metastases (BMs) that recur after stereotactic radiosurgery (SRS) remain limited. METHODS The authors provide the collective experience of 4 institutions where treatment BMs recurred SRS was performed with laser ablation (SLA). RESULTS Twenty-six (in 23 patients) were treated SLA (2 patients each underwent 2 SLAs separate lesions, and a third serial discrete BMs). Histological findings in included following: breast (n = 6); lung melanoma 5); colon 2);...
The CheckMate 141 trial found that nivolumab improved survival for patients with recurrent or metastatic head and neck cancer (HNC). Despite the survival, is much more expensive than standard therapies. This study assesses cost-effectiveness of treatment HNC. We constructed a Markov model to simulate single-agent therapy platinum-refractory Transition probabilities, including disease progression, probability toxicity, were derived from clinical data, while costs (in 2017 US dollars) health...
OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma is generally believed to be more sensitive chemotherapy than astrocytoma comparable grades. In this study authors compare survival benefit gross-total (GTR) in patients with oligodendroglioma relative astrocytoma. METHODS Using Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database,...
Middle meningeal artery embolization (MMAE) has emerged as a promising therapy for chronic subdural hematomas (cSDHs). The efficacy of standalone MMAE compared with concurrent surgery is largely unknown.
Background With transradial access (TRA) being more progressively used in neuroendovascular procedures, we compared TRA with transfemoral (TFA) middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH). Methods Consecutive patients undergoing MMAE cSDH at 14 North American centers (2018–23) were included. and TFA groups using propensity score matching (PSM) controlling for: age, sex, concurrent surgery, previous thickness side, midline shift, pretreatment...
INTRODUCTION: Multiple preferences exist in terms of embolic materials middle meningeal artery embolization (MMAE) for chronic subdural hematoma (cSDH) with limited comparative literature data. METHODS: Consecutive patients undergoing MMAE cSDH at 14 North-American centers (2018-2023) were included. Patients classified into 3 groups a) particles, b) Onyx, c) n-BCA. The endpoints unplanned rescue surgery and radiographic success (=50% reduction thickness last imaging "minimum 2-weeks")....
No statistically significant differences in outcomes were found based on whether the middle meningeal artery embolization was performed before or after surgery early late surgery.
Middle meningeal artery embolization (MMAE) is emerging as a safe and effective standalone intervention for non-acute subdural hematomas (NASHs); however, the risk of hematoma recurrence after MMAE in coagulopathic patients unclear. To characterize impact coagulopathy on treatment outcomes, we analyzed multi-institutional database who underwent NASH. We classified 537 between 2019 2023 by status. Coagulopathy was defined use anticoagulation/antiplatelet agents or pre-operative...
OBJECTIVE Stereotactic laser ablation (SLA) is typically performed in the setting of intraoperative MRI or a staged manner which probe insertion operating room and thermal takes place an suite. METHODS The authors describe their experience, SLA for glioblastoma (GBM) treatment was entirely within conventional suite using SmartFrame stereotactic device. RESULTS All 10 patients with GBM (2 isocitrate dehydrogenase 1 mutation [mIDH1] 8 wild-type IDH1 [wtIDH1]) were followed > 6 months. One...
It is well established that traumatic brain injury (TBI) associated with the development of psychiatric disorders. However, impact disorders on TBI outcome less understood. We examined outcomes patients who experienced a subdural hemorrhage and whether comorbid disorder was change in outcome. A retrospective observational study performed California Office Statewide Health Planning Development (OSHPD) Nationwide Inpatient Sample (NIS). Patients hospitalized for acute were identified using...
Background Middle meningeal artery embolization (MMAE) is a safe and effective treatment for chronic subdural hematoma (cSDH); however, the appropriate level of postoperative care unknown. Objective To evaluate whether elective MMAE cSDH could be safely performed in an outpatient setting. Methods This was multicenter, retrospective study patients with who underwent MMAE. Patients were categorized as either inpatient (admitted ≥1 night hospitalization after MMAE) or (discharged on same day...
Older age has been associated with worse outcomes in low-grade gliomas (LGGs). Given their rarity the older population, determining optimal treatment plans and patient remains difficult.To retrospectively study LGG survival an population stratified by molecular genetic profiles.We included patients ≥40 yr pathologically confirmed World Health Organization grade II treated at a single institution between 1995 2015. We collected tumor genomic information when available.Median overall for...