Abstract Aims Alcohol use disorder is highly heterogeneous. One approach to understanding this heterogeneity the identification of drinker subtypes. A candidate classification consists reward and relief The current study examines a novel self-report measure reward, relief, habit drinking for its clinical correlates subjective response (SR) alcohol administration. Methods Non-treatment-seeking heavy drinkers (n = 140) completed brief scale (RRHDS). subset sample 67) an intravenous Individuals...

The present study examined the association of mood states, alcohol cue exposure, and their synergistic effect on consumption subjective craving during early abstinence. A community sample 50 (24 females, average age 41.68 years old) individuals with current use disorder an intrinsic motivation to reduce/quit completed a quit attempt daily diary assessments (DDAs). Electronic DDAs asked about previous-day drinking, craving, exposure cues. Analyses using mixed models tested main effects states...

Gabapentin, an anticonvulsant medication, has been proposed as a treatment for alcohol use disorder (AUD). A multisite study tested gabapentin enacarbil extended-release (GE-XR; 600 mg/twice day), prodrug formulation, combined with computerized behavioral intervention, AUD. In this trial, the GE-XR group did not differ significantly from placebo on primary outcome of percent subjects no heavy drinking days. Despite null findings, there is considerable interest in using machine learning...

Abstract Aims This study aimed to compare reward, relief, and habit treatment-seeking individuals on recent drinking, alcohol use disorder (AUD) phenomenology, mood. The second aim of the was evaluate predictive validity profiles. Method Treatment-seeking with an AUD (n = 169) were recruited participate in a medication trial for (NCT03594435). Reward, drinking groups assessed using UCLA Reward Relief Habit Drinking Scale. Group differences at baseline evaluated univariate analyses variance....

Abstract Background Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly effective. The development of efficacious medications AUD remains high research priority with recent emphasis on identifying novel molecular targets treatment to efficiently screen new compounds aimed at those targets. Ibudilast, phosphodiesterase inhibitor, has been advanced as addiction pharmacotherapy that neurotrophin signaling neuroimmune...

Abstract Aims Natural processes of change have been documented in treatment-seekers who begin to reduce their drinking anticipation treatment. The study examined whether non-treatment-seeking problem drinkers would engage reduction participating a research study. Methods Non-treatment-seeking (n = 935) were culled from five behavioral pharmacology studies. Participants reported on alcohol use during the past 30 days using Timeline Followback. Cluster analysis identified distinct...

Abstract Introduction Previous studies have highlighted a strong bidirectional relationship between cigarette and alcohol consumption. To advance our understanding of this the present study uses behavioral economic approach in community sample (N = 383) nontreatment seeking heavy drinking smokers. Aims Methods The aims were to examine same-substance cross-substance relationships use, latent factors demand. A smokers completed an in-person assessment battery including measures tobacco use as...

Abstract Aims Sleep problems are common among individuals with alcohol use disorder (AUD) and is often associated a heightened relapse risk. The present study examines the relationship between sleep current AUD during 6-day quit attempt as part of medication study. Methods secondary analysis trial for AUD. Individuals (N = 53, 26 females) were randomized to active or matched placebo. Randomized participants completed week-long titration (Days 1–7). Following period, attended an in-person...

Insomnia commonly co-occurs with alcohol use disorder (AUD) and predicts poorer outcomes for those AUD. AUD are individually associated increases in systemic inflammation. inflammation both serve as risk factors relapse However, little is known about the relationship between insomnia individuals Therefore, present study examined severity of symptoms plasma levels inflammatory cytokines a sample treatment-seeking an

Objective: Individuals in the United States with opioid use disorder (OUD) have high rates of co-occurring alcohol (AUD). However, there is limited research on co-use patterns among and use. The present study examined relationship between treatment-seeking individuals an OUD. Method: utilized baseline assessment data from a multisite, comparative effectiveness trial. Participants OUD had used non-prescribed opioids last 30 days (n = 567) reported their during past 30-days using Timeline...

Abstract Background Cigarette smoking among adults in the USA is a leading cause of preventable death worldwide, even though there has been decline prevalence since 2005. The addictive nature nicotine chief reason smokers continue to use tobacco. Although majority report desire quit smoking, small minority who attempt achieve long-term cessation. Combined, cessation best practices include coordinated medication and behavioral treatments. However, these treatments are not currently adequately...

Background: Cigarette smoking, which poses significant health risks, is prevalent among vulnerable populations commonly treated by safety net providers. A large-scale implementation science project on specialty tobacco use treatment was launched within the Los Angeles County Health Agency. The first phase of this study seeks to summarize and compare smoking cessation attitudes providers at Department Services (DHS) Mental (DMH). Methods: In total, 467 care (DHS = 322; DMH 145) completed a...

Subjective response (SR) to alcohol represents a biobehavioral risk factor for heavy drinking and developing use disorder (AUD). Identifying moderators of SR have been hindered by small sample sizes that are often used in administration studies.This study combined data from multiple trials test whether sex, family history problems, impulsivity (via delay discounting) predict alcohol, comprised four domains: stimulation, sedation, negative affect, craving. Non-treatment-seeking drinkers (N =...

Abstract Background Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly effective. The development of efficacious medications AUD remains high research priority with recent emphasis on identifying novel molecular targets treatment to efficiently screen new compounds aimed at those targets. Ibudilast, phosphodiesterase inhibitor, has been advanced as addiction pharmacotherapy that neurotrophin signaling neuroimmune...

Varenicline has shown promise for treating alcohol use disorder (AUD); however, not everyone will respond to varenicline. Machine-learning methods are well suited identify treatment responders. In the present study, we examined data from National Institute on Alcohol Abuse and Alcoholism Clinical Intervention Group multisite clinical trial of varenicline using two machine-learning methods. Baseline characteristics taken a randomized were as potential moderators response qualitative...

Abstract Background Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly effective. The development of efficacious medications AUD remains high research priority with recent emphasis on identifying novel molecular targets treatment to efficiently screen new compounds aimed at those targets. Ibudilast, phosphodiesterase inhibitor, has been advanced as addiction pharmacotherapy that neurotrophin signaling neuroimmune...

Background: Varenicline is FDA-approved for smoking cessation but has shown promise the treatment of alcohol use disorder (AUD). However, not all individuals will respond to varenicline. Machine learning methods are well-suited identify responders using data-driven tools. Towards identifying varenicline and improving application machine prediction clinical response in AUD, present study examines data from NCIG multisite trial two methods.Methods: Data this secondary analysis were drawn a...