A5044961426- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Forensic Toxicology and Drug Analysis
- Stress Responses and Cortisol
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Health, Environment, Cognitive Aging
- Pharmacological Effects and Assays
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Pharmacological Effects and Toxicity Studies
- Psychedelics and Drug Studies
- Pain Mechanisms and Treatments
National Institute on Drug Abuse
2017-2024
National Institutes of Health
2018-2024
National Research Council of Thailand
2021
Behavioral Pharma (United States)
2021
University of Pittsburgh
2009-2020
VA Pittsburgh Healthcare System
2007-2020
Center for the Neural Basis of Cognition
2008-2012
Carnegie Mellon University
2011-2012
Center for Neurosciences
2011
Veterans Health Administration
2008
High concentrations of cocaethylene (EC), the ethyl ester benzoylecgonine, were measured in blood individuals who had concurrently used cocaine and ethanol. Since powerful reinforcing effects appear to be dependent on inhibition dopamine reuptake brain, we compared EC uptake system its behavioral with those cocaine. was equipotent respect binding [3H]GBR 12395 complex, [3H]dopamine into synaptosomes ability increase extracellular concentration nucleus accumbens following systemic...
Abstract: Cocaethylene is a pharmacologically active metabolite resulting from concurrent cocaine and ethanol consumption. The effects of cocaethylene on extracellular levels dopamine in the nucleus accumbens, serotonin striatum were characterized vivo anesthetized rat. Both intravenous (3 μmol/kg) intraperitoneal (44 routes administration used. In addition to monitoring neurotransmitter levels, microdialysate determined at 4‐min intervals after administration, 20‐min administration....
Interactions between serotonin (5-HT) and dopamine (DA) neuronal systems in the prefrontal cortex (PFC) may be important pathophysiology of cognitive disorders such as schizophrenia. We have examined effect 5-HT, applied locally through a microdialysis probe, on extracellular DA PFC, compared response to that observed striatum. 5-HT concentrations 1 10 microM increased dose-dependently greater extent PFC than The was pharmacologically characterized determine receptor subtype mediating...
The present study investigated the impact of systemic (i.p.) ethanol administration on extracellular levels serotonin and glutamate in prefrontal cortex nucleus accumbens Lewis Fischer 344 rat strains using vivo microdialysis. At 1.0 g/kg, elicited a significant increase accumbens-dialysate both 5-HT (44% +/- 16, P = 0.002) glutmate (90% 43, 0.009) rats. In rats, there was no (6% 7: 0.5), trend toward an (88% 46: 0.1). 0.5 2.0 g/kg doses did not result any change or either strain. basal...
Cocaine users display a wide range of cognitive impairments. Because treatment outcome is dependent on baseline ability, it clinically important to understand the underlying neurobiology these deficits. Therefore, crucial determine whether cocaine exposure by itself an etiological factor and, if so, overall nature deficits associated with use. This will help guide therapeutic approaches that address components use improve outcome. We used rhesus monkeys in longitudinal study which 14 animals...
In many cognitive tasks, lapses (spontaneous errors) are tacitly dismissed as the result of nuisance processes like sensorimotor noise, fatigue, or disengagement. However, some could also be caused by exploratory noise: randomness in behavior that facilitates learning changing environments. If so, then strategic would need only up-regulate (rather than generate) exploration to adapt a environment. This view predicts more frequent should associated with greater flexibility because these...
Using a model of recreational cocaine consumption, we have determined in four rhesus monkeys the impact self-administered on mesolimbic and sensorimotor striatal dopaminergic neurotransmission. The effects repeated within self-administration session across multiple sessions over 6 month period were by use fixed-ratio microdialysis procedures. exposure to was modest, with at most two 0.5 mg/kg infusions permitted each weekly session. Within session, acute tolerance ability elevate...
Abstract: The effect of the anxiogenic β‐carboline methyl‐β‐carboline‐3‐carboxyamide (FG 7142) on dopamine release in prefrontal cortex and striatum awake freely moving rat was determined using technique microdialysis. FG 7142 (25 mg/kg, i.p.) caused a time‐dependent increase which statistically significantly greater than response to vehicle administration. Dopamine unaltered by 7142. Pretreatment animals with benzodiazepine antagonist Ro 15‐1788 (30 i.p., 15 min prior administration)...
Rats were placed in one of two novel test environments for behavioral observation. In one, exploratory behavior (assessed by hole pokes) and locomotion assessed during a 10-min session. the other, chewing varied objects on cage floor was rated over 20-min Within 2–18 days, animals anesthesized microdialysis probes implanted into nucleus accumbens measurement basal d-amphetamine-stimulated levels dopamine (DA). These measures then correlated with individual rating collected earlier from...
Abstract Brain imaging studies have suggested that the NMDA antagonist ketamine is as potent a releaser of striatal dopamine amphetamine. This conclusion contradicts microdialysis findings in rodent antagonists, contrast to amphetamine, little or no effect on release. The present study addressed two mechanisms could account for this discrepancy: 1) whether there species difference, i.e., rodents vs. primates, responsivity and 2) rapid uptake prevents reliable measures synaptic release by...
Decreased cognitive control over prepotent responses has been hypothesized to contribute ethanol-induced behavioral disinhibition. However, the effects of ethanol on specific domains associated with decision making have not extensively studied. We examined impact acute administration performance nonhuman primates. Studies were conducted using 0.2, 0.5, and 1 g/kg intravenous in rhesus macaques performing touch screen–based tasks examining stimulus discrimination, reversal, response...
The psychostimulant amphetamine (AMPH) is frequently used to increase catecholamine levels in attention disorders and positron emission tomography imaging studies. Despite the fact that most radiotracers for studies are characterized non-human primates (NHPs), data on regional differences of effect AMPH NHPs very limited. This study examined impact extracellular dopamine (DA) medial prefrontal cortex caudate using microdialysis. In addition magnitude, we observed striking temporal profile DA...