A5037690990- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Forensic Toxicology and Drug Analysis
- Memory and Neural Mechanisms
- Behavioral and Psychological Studies
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Psychedelics and Drug Studies
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects and Assays
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Attention Deficit Hyperactivity Disorder
- Hormonal and reproductive studies
- Adenosine and Purinergic Signaling
- Parkinson's Disease Mechanisms and Treatments
- Biochemical effects in animals
National Institute on Drug Abuse
2015-2024
Office of Extramural Research
2024
National Institutes of Health
2005-2023
International Drug Development
2023
National Institute on Alcohol Abuse and Alcoholism
2019-2023
United States Department of Health and Human Services
2003-2012
American University
1980-2005
Behavioral Pharma (United States)
1990-1999
Georgetown University
1991-1999
Augusta University
1995
Cannabis use disorder (CUD) is widespread, and there no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, signaling-specific inhibitor cannabinoid receptor 1 (CB1-SSi). AEF0117 selectively inhibits subset intracellular effects resulting from Δ9-tetrahydrocannabinol (THC) binding without modifying behavior per se. In mice non-human primates, decreased self-administration THC-related behavioral impairment producing significant adverse effects....
The reinforcing and subjective effects of morphine were determined in five human volunteers with histories i.v. heroin abuse. Subjects responded under a second-order schedule i.m. injection. Under this schedule, every 100 lever presses produced brief stimulus light [fixed ratio (FR) 100:s]; the 30th completion FR requirement turned on for 15 min subject received an injection [FR 30 (FR 100:s)]. Once each weekday or placebo was available schedule. Each drug dose 1 week. these conditions did...
3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with stimulatory cardiovascular effects that can lead to serious medical complications. Here, we examined the pharmacological mechanisms underlying these actions of MDPV in conscious rats.Male Sprague-Dawley rats had telemetry transmitters surgically implanted for measurement BP and heart rate (HR). On test days, were placed individually standard isolation cubicles. Following drug treatment, parameters monitored 3 h...
1. The cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and A2A 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) were investigated in rats implanted with telemetry transmitters for measurement blood pressure heart rate. 2. Intraperitoneal (i.p.) injections CPA led to dose-dependent decreases both These 0.3 mg kg(-1) antagonized by i.p. antagonist 8-cyclopentyl-1,3-dimethyl-xanthine (CPT), but not...
Abstract Transcription factors are known to act as gene expression regulators, possibly linking extracellular stimuli long‐term modifications at the neuronal level. Such may potentially ‐underlie chronic psychostimulant‐ and stress‐induced behavioral alterations. This study illustrates how a 2 week, twice daily 7.5 mg/kg d‐amphetamine or saline regimen alters rat brain regional of transcription factor genes, including c fos , fos‐B, jun‐B, jun zif 268, seeks potential correlations between...
Cocaine (0.03-5.6 mg/kg i.v.) produced a dose-dependent and prolonged increase in mean arterial blood pressure heart rate conscious rats. The 0.3 1 doses of cocaine potentiated the pressor response to exogenous norepinephrine (0.2 microgram/kg), whereas lower (0.03 0.1 mg/kg) higher (3 5.6 were ineffective. Desipramine (0.03-1 mg/kg), prototype uptake blocker, did not alter or rate. Nisoxetine (0.01-1 another selective small brief (< 5 min) response, but tachycardiac response. Unlike...
The effects of cocaine on cardiovascular function were studied in six conscious squirrel monkeys. Cocaine (0.01-3 mg/kg i.v.) increased mean arterial blood pressure and heart rate (HR) a dose-dependent manner. effect HR reached maximum at 0.3 mg/kg. Doses up to 3 did not evoke cardiac rhythm disturbances. Pentobarbital or halothane anesthesia attenuated the pressor tachycardiac cocaine. Antagonism response by was significantly greater than that pentobarbital. Halothane, but pentobarbital,...