A5065464485- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Neuroscience and Neuropharmacology Research
- Behavioral and Psychological Studies
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Memory and Neural Mechanisms
- Behavioral Health and Interventions
- Smoking Behavior and Cessation
- Receptor Mechanisms and Signaling
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Opioid Use Disorder Treatment
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Animal Behavior and Welfare Studies
- Olfactory and Sensory Function Studies
- Alcohol Consumption and Health Effects
- Animal Nutrition and Physiology
- Attention Deficit Hyperactivity Disorder
- Gambling Behavior and Treatments
- Mental Health Research Topics
- Pharmacological Effects and Toxicity Studies
- Homelessness and Social Issues
The University of Texas Health Science Center at San Antonio
2014-2025
The University of Texas at San Antonio
2019
University of Leeds
2015-2016
University of Missouri
2015
The University of Texas at Austin
2009
Bexar County Medical Examiner's Office
2008
GTx (United States)
2008
Northeastern University
2005
Temple University
2000-2005
The University of Sydney
1990-2004
Although cocaine binds to several sites in the brain, biochemical receptor mechanism or mechanisms associated with its dependence producing properties are unknown. It is shown here that potencies of cocaine-like drugs self-administration studies correlate their inhibiting [3H]mazindol binding dopamine transporters rat striatum, but not a large number other presynaptic and postsynaptic sites. Thus, related substance abuse proposed be one uptake inhibition.
The reinforcing and subjective effects of morphine were determined in five human volunteers with histories i.v. heroin abuse. Subjects responded under a second-order schedule i.m. injection. Under this schedule, every 100 lever presses produced brief stimulus light [fixed ratio (FR) 100:s]; the 30th completion FR requirement turned on for 15 min subject received an injection [FR 30 (FR 100:s)]. Once each weekday or placebo was available schedule. Each drug dose 1 week. these conditions did...
ABSTRACT Aims Current clinical studies often use a breath carbon monoxide (BCO) cut‐off level of 8 parts per million (p.p.m.) or higher to identify smoking. In this study, the BCO as an indicator smoking over past 24 hours was re‐examined. Design and self‐reported were obtained each weekday for up 14 weeks in 213 subjects paid deliver reduced values. Analysis 12 386 paired values reported analyzed. Findings The 25% quartile, median 75% quartile 1, 1 2 p.p.m. on non‐smoking days 2, 5 days,...
This study examines the effectiveness of using vouchers to reinforce either provision urine samples testing negative for illicit drugs (UA group) or completion objective, individually defined, treatment-plan-related tasks (TP group). A third group was assigned clinic's standard treatment (STD Participants were randomly groups after a 6-week baseline-stabilization period. Urine specimens collected thrice weekly throughout study. In UA condition, participants earned $5 (U.S. dollars) in each...
Background Several studies demonstrate the utility of Alcohol Monitoring Systems’ ( AMS ) transdermal alcohol concentration TAC monitor to objectively quantify drinking. standard criteria (i.e., >0.02 g/dl) used for drinking detection are deliberately conservative, but consequently only detect equivalent 5 or more drinks. Our study sought characterize sensitivity measurement low‐level defined as consumption 1 3 beers. Methods Data were pooled from giving controlled doses 1, 2, 3, 4, and...
This study examined whether voucher delivery arrangements affect treatment outcome. First, 90 cocaine-dependent adults were randomly assigned to behavioral counseling or plus vouchers for cocaine-free urine samples. The value of each was low at the beginning but increased as patient progressed (Voucher Schedule 1). Voucher 1 produced no improvements relative only. Next, 23 patients received on either 2. 2 began with high values, requirements earning progressed. Average durations cocaine...
Contingency management (CM) effectively treats addictions by providing abstinence incentives. However, CM fails for many who do not readily become abstinent and earn Shaping may improve outcomes in these hard-to-treat (HTT) individuals. sets intermediate criteria incentive delivery between the present behavior total abstinence. This should result HTT individuals having improving, rather than poor, outcomes. We examined whether shaping improved smokers (never during a 10-visit...
Impulsivity is a defining characteristic of adolescence. Compared to adults, for example, adolescents engage in higher rates drug and alcohol experimentation, risky sexual practices, criminal activity. Such behavior may reflect reduced sensitivity long-term consequences during Recently, our lab has attempted refine mouse procedures study developmental trends decision making the laboratory. In present experiment, we examined delayed rewards C57BL/6J (B6) DBA/2J (D2) mice adolescence adulthood...
Thirty-five psychiatric patients were interviewed under standard conditions and confronted for the first time in a way with fact that interview was being recorded. Thirty-one intake interviews of applicants outpatient treatment. In evaluating patient response attitude, only their overt replies to told recording, other comments relating directly his cognizance recorded, considered. Sixty percent showed no manifestations disturbance about recording; another 20% manifested after initial moments...
Abstract Background High rates of driving while intoxicated persist, and recidivism is common. Recently, we demonstrated that 8 weeks transdermal alcohol concentration (TAC)‐based contingency management (CM) reduced heavy drinking (≥5 [men] or ≥4 [women] standard drinks) in 145 DWI arrestees under pretrial supervision. Here, report 1‐month (postintervention) follow‐up outcomes for a subgroup participants who were not Mandated to wear monitors. Methods After the intervention, Non‐Mandated ( n...