Artificial micro‐/nanoswimmers have various potential applications including minimally invasive diagnosis and targeted therapies, environmental sensing monitoring, cell manipulation analysis, lab‐on‐a‐chip devices. Inspired by natural motile bacteria such as E. Coli , artificial bacterial flagella (ABFs) are one kind of magnetic helical microswimmers. ABFs can perform 3D navigation in a controllable fashion with micrometer precision under low‐strength rotating fields (<10 mT) promising...

An approach for batch preparation of liposome-functionalized microdevices is demonstrated remotely controlled single-cell drug delivery. The liposome functionalized artificial bacterial flagella exhibit corkscrew swimming in 3D with micrometer positioning precision by applying an external rotating magnetic field. devices are also capable delivering water-soluble drugs to single cells vitro.

The loss of expression chondrogenic markers during monolayer expansion remains a stumbling block for cell-based treatment cartilage lesions. Here, we introduce sulfated alginate hydrogels as biomimetic biomaterial that induces cell proliferation while maintaining the phenotype encapsulated chondrocytes. Hydroxyl groups were converted to sulfates by incubation with sulfur trioxide–pyridine complex (SO3/pyridine), yielding material cross-linkable calcium chloride. Passage 3 bovine chondrocytes...

Water bodies are being threatened continuously by various anthropogenic pollutants such as organic dyes and bacteria which led to scarcity of fresh water suitable for drinking irrigation. Therefore, different treatment methods have been implemented before the discharge contaminated wastewater into bodies. In this report, green-synthesized silver nanoparticles (AgNPs) were evaluated in degradation bacterial decontamination. The S. costus root aqueous extract was used an environmentally benign...

The layer-by-layer (LbL) technique has been widely used to produce nanofilms for biomedical applications. Naturally occurring polymers such as ECM macromolecules are attractive candidates LbL film preparation. In this study, we assessed the build-up of type I collagen (Col1)/chondroitin sulfate (CS) or Col1/Heparin (HN) on polydimethylsiloxane (PDMS) substrates. was by quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM). Integrin-mediated cell adhesion...

The cellular microenvironment plays a crucial role in directing proliferation and differentiation of stem cells. Cells interact with their via integrins that recognize certain peptide sequences extracellular matrix proteins. This receptor-ligand binding has profound impact on cell fate. Interactions human bone marrow mesenchymal cells (hMSCs) the triple helical collagen mimetic, GPC(GPP)5-GFOGER-(GPP)5GPC-NH2, fibronectin adhesion peptide, RGD, were studied degradable or nondegradable...

Sulfated glycosaminoglycans (GAGs) are principal elements of the extracellular matrix, where they involved in a plethora signaling pathways mainly via interactions with diverse proteins such as growth factors and cytokines. However, mechanisms that drive these not yet clear, mostly because difficulty to access large quantities homogeneously sulfated natural GAGs. In this work, GAG mimics synthesized from readily available alginate different degrees sulfation (DS, 0.8 2.6) by simple process....

The blood–brain barrier (BBB) poses a significant challenge for drug delivery and is linked to various neurovascular disorders. In vitro BBB models provide tool investigate permeation across the barrier's response external injury events. Yet, existing lack fidelity in replicating BBB's complexity, hindering comprehensive understanding of its functions. This study introduces three-dimensional (3D) model using polyethylene glycol (PEG) hydrogels modified with biomimetic peptides that represent...

Objectives: The aim of this study was to compare the accuracy apical gauging using NiTi K-files and gutta-percha cones determine level agreement between two methods a Scanning Electron Microscope (SEM). Methods: 75 circular straight canals mandibular first premolars were used. Canals shaped R-Motion system (RM; FKG Dentaire, La Chaux-de-Fonds, Switzerland) gauged matching shaping instrument. Diameters measured on SEM images used as reference standard. Results: There statistically significant...

Current in vitro models fail to recapitulate specific physiological properties of the human blood-brain barrier (BBB); hence need for a reliable platform study central nervous system diseases and drug permeability. To mimic normally tight interface, primary endothelial cells (HAECs) astrocytes (A) were grown confined space physical scaffold created by gelatin methacrylate (GelMA) hydrogel allow optimal astrocyte-endothelial cell direct/indirect interaction. Evidence physiologically relevant...

Connective tissue growth factor (CTGF) holds great promise for enhancing the wound healing process; however, its clinical application is hindered by low stability and challenge of maintaining effective concentration at site. Herein, we developed novel double-emulsion alginate (Alg) heparin-mimetic sulfate (AlgSulf)/polycaprolactone (PCL) nanoparticles (NPs) controlled CTGF delivery to promote accelerated healing. The NPs' physicochemical properties, cytocompatibility, activity were assessed...

This work shows that alginates can be sulfated to engineer defined substrates control growth factor binding and neural growth.

The preparation of metallic nanoparticles using green synthetic approaches and its application toward the efficient degradation environmentally hazardous dyes constitutes an attractive alternative to currently employed methods. In current report, synthesis silver (AgNPs) was successfully achieved Actinidia deliciosa (kiwifruit) peel aqueous extract as a bioreducing agent under optimized conditions. experimental parameters were in terms reactant ratio, reaction temperature, time. biogenic...

Abstract Sulfated glycosaminoglycans (sGAGs) are vital molecules of the extracellular matrix (ECM) nervous system known to regulate proliferation, migration, and differentiation neurons mainly through binding relevant growth factors. Alginate sulfate (AlgSulf) mimics sGAGs binds factors such as basic fibroblast factor (FGF‐2). Here, thin films biotinylated AlgSulf (b‐AlgSulf n ) engineered with sulfation degrees (DS = 0.0 2.7) effect polysaccharide concentration on FGF‐2 nerve (β‐NGF)...