A5007120492- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Neuroblastoma Research and Treatments
- Nutrition and Health in Aging
- Cancer Treatment and Pharmacology
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
- Helicobacter pylori-related gastroenterology studies
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
Kansai Rosai Hospital
2016-2025
Osaka National Hospital
2003-2025
Osaka University
2008-2025
Japan Organization of Occupational Health and Safety
2020
Nagoya University
2012
Kinki Central Hospital
2007
434 Background: Neoadjuvant docetaxel, cisplatin, and 5-FU (DCF) has become the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) in Japan, based on result of JCOG1109. In this study, more non-cancer-related deaths were observed (CF) plus radiotherapy (CF-RT) arm compared to CF DCF arm. However, details these remain unclear. We aimed evaluate influence neoadjuvant therapies using data from Methods: analyzed patients' characteristics,...
Gene expression profiling is a valuable tool for identifying differentially expressed genes in studies of disease subtype and patient outcome various cancers. However, it remains difficult to assign biological significance the vast number genes. There an increasing awareness gene profile as important part contextual molecular network at play complex processes such cancer initiation progression. This study analysed transcriptional profiles commonly activated different stages gastric cancers...
Cytokeratins (CKs) are structural marker proteins specific for epithelial cells. However, recent studies indicate their involvement in cancer progression. We evaluated CK18 and its filament partner, CK8 expression, by immunohistochemistry 210 resected specimens from patients with oesophageal squamous cell carcinoma (OSCC). also analysed the relationship between expression various clinicopathological parameters including prognosis. Neither nor was expressed non-cancerous epithelium whereas...
Objective: We conducted a multicenter randomized prospective phase 2 trial of chemoradiotherapy (CRT) versus chemotherapy (CT) as initial induction therapy for conversion surgery (CS) in clinical T4b esophageal cancer. compared treatment effects and adverse events (AEs). Summary Background Data: Although followed by CS is potentially curative cancer, the optimal unclear. Methods: Ninety-nine patients with cancer were randomly allocated to (Group A, n = 49) or CT B, 50) treatment. CRT...
Gastric cancer is one of the most common causes cancer-related death worldwide. Surgical resection with lymph node dissection only potentially curative therapy for gastric cancer. However, appropriate extent accompanied by gastrectomy remains controversial. In East Asian countries, especially in Japan and Korea, D2 has been regularly performed as a standard procedure. Western surgeons perform D1 because associated high mortality morbidity compared to those alone but does not improve 5-year...
Abstract Background Although perioperative treatment has been the standard of care for resectable gastric cancer in West, postoperative adjuvant chemotherapy is still Japan. We conducted first phase 2 trial to investigate efficacy and safety neoadjuvant docetaxel, oxaliplatin, S‐1 (DOS) cStage III or esophagogastric junction (EGJ) adenocarcinoma Methods Eligibility criteria included stomach EGJ. Patients received docetaxel (40 mg/m , day 1), oxaliplatin (100 (80 days 1–14) during a 3‐week...
Abstract Background No reliable marker has been identified to predict postoperative recurrence of gastric cancer. We designed a clinical trial investigate the utility serum NY-ESO-1 antibody responses as predictive for in Methods A multicenter prospective study was conducted between 2012 and 2021. Patients with resectable cT3-4 cancer were included. Postoperative p53 serially evaluated every 3 months 1 year patients positive preoperative responses. The rate assessed by positivity at 12...
Abstract Aim Upfront chemotherapy (uCT) or upfront chemoradiotherapy (uCRT) followed by surgery is generally accepted as the standard treatment for patients with locally advanced esophageal cancer. A substantial proportion of achieve a pathological complete response (pCR) primary tumor treatment. This retrospective study aimed to clarify prognostic factors cancer who pCR in after and whether prognosis receive uCT differs from that uCRT. Methods included 121 achieved 40 Univariate...
402 Background: The efficacy of conversion surgery in patients with unresectable advanced gastric cancer at the initial diagnosis who converted to be resectable due remarkable response chemotherapy is unclear. To evaluate short- and long-term outcomes for initially cStage IVB/pStage IV as basic data JCOG2301 trial, which a randomized controlled trial comparing continuation chemotherapy, multicenter retrospective cohort study was conducted Stomach Cancer Study Group Japan Clinical Oncology...
Transmembrane protease serine 4 (TMPRSS4) is a member of the type II transmembrane family known to be upregulated in many malignancies. We previously showed that TMPRSS4 may prognostic biomarker and therapeutic target for gastric cancer (GC), especially stage III. In this retrospective study conducted at 10 institutions, all 325 patients underwent R0 resection involving D2 lymph node dissection. expression was examined using immunohistochemical analysis. 44.9% participants. The 5-year...