A5079557148- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Immunotherapy and Immune Responses
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Multiple and Secondary Primary Cancers
- Head and Neck Cancer Studies
- Protein Kinase Regulation and GTPase Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Melanoma and MAPK Pathways
- Abdominal vascular conditions and treatments
- Bone and Dental Protein Studies
- Potassium and Related Disorders
- Soft tissue tumor case studies
- Ovarian cancer diagnosis and treatment
Kindai University
2016-2025
Kindai University Hospital
2024
European Neuroendocrine Tumor Society
2018
Niigata University
2003
Kobe University
1995-2001
Hokkaido University
1999
Kobe Rosai Hospital
1994-1995
Molecular targeted therapy is expected to be a promising therapeutic approach for the treatment of esophageal squamous cell carcinoma (ESCC); however, gene amplification status molecular genes in ESCC remains largely unclear. The EGFR, HER2, FGFR2 and MET was examined using real-time PCR-based copy number assay 245 surgical specimens formalin-fixed, paraffin-embedded samples. Fluorescence situ hybridization (FISH) comparative genomic analyses verified results assay. EGFR mutation detected...
Neoadjuvant chemotherapy for resectable advanced esophageal squamous cell carcinoma (ESCC) requires reassessment. We have conducted a trial aiming at the comparison between DCF and ACF concerning perioperative adverse events.Patients were randomly assigned to receive either [docetaxel 70 mg/m2, cisplatin mg/m2 on day 1, 5-fluorouracil (5-FU) 700 5 days] every 3 weeks or (adriamycin 35 5-FU 7 days) 4 weeks. Each group consisted of 81 patients. Two cycles preoperative planned, after which...
To improve the prognosis of clinically resectable type 4 or large 3 gastric cancer (GC), we performed a phase I/II study neoadjuvant-radiotherapy combined with S-1 plus cisplatin. Phase I, standard + dose-escalation design, was to define recommended II dose. Efficacy and safety were evaluated in II. The three dose levels as follows: level 0, 60 mg/m2 on days 1-14 cisplatin day 1; 1, 80 2, 22-35, 1 22. starting 1. Radiotherapy delivered at total 40 Gy fractions for weeks. A six patients...
Abstract Background Early response of the primary tumor (PT) to neoadjuvant chemotherapy (NAC) in patients with esophageal squamous cell carcinoma (ESCC) is considered a potential predictor postoperative prognosis. However, role metastatic lymph nodes (LNs) remains poorly understood. This study aimed compare predictive value early PT and LNs for Methods We enrolled 124 consecutive who received NAC-docetaxel, cisplatin, 5-fluorouracil (DCF) followed by surgery ESCC between April 2010 March...
Conservation of the structure and function Ras proteins has been observed in a variety eukaryotic organisms. However, nature their downstream effectors appears to be quite divergent; adenylyl cyclase protein kinase Raf-1, which do not share any structural homology with each other, are budding yeast higher organisms, respectively. We show here that Byr2, known act Ras1 mating pheromone signal transduction system Schizosaccharomyces pombe, binds directly GTP-dependent manner. The region Byr2...
Introduction: This study aimed to clarify the impact of average relative dose intensity (RDI) neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF-NAC) for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Materials Methods: To identify optimal RDI, recurrence-free survival (RFS) cumulative incidence function (CIF) recurrence were calculated in low high RDI groups any cut-off points. The was defined as highest administered a significant increase...
B-Raf is regulated by Ras protein and acts as a mitogen-activated (MAP) kinase in PC12 cells brain. undergoes series of post-translational modifications on its C-terminal CAAX motif, the are critical for function. To elucidate role interaction with, activation of, B-Raf, we have analyzed direct association between H-Ras constructed an vitro system H-Ras. By using methods based inhibition yeast adenylyl cyclase or RasGAP activity binding assays, shown that segment corresponding to amino acid...
<i>Background:</i> There is no standard treatment available for gastric cancer patients whose sole ‘non-curative factor’ positivecytological findings in peritoneal washings (CFPW). The aim of this study was to examine the safety, pharmacokinetics and efficacy free intraperitoneal cells chemotherapy with paclitaxel after gastrectomy en bloc D2 lymph node dissection cases positive CFPW. <i>Methods:</i> Ten who underwent systemic lymphadenectomy dissection, without any...
Objectives: To elucidate the efficacy of adjuvant vaccine monotherapy using 3 Human Leukocyte Antigen (HLA)-A ∗ 24-restricted tumor-specific peptide antigens for ESCC, upregulated lung cancer 10, cell division cycle associated 1, and KH domain-containing protein overexpressed in 1. Summary Background Data: ESCC patients with pathologically positive nodes (pN(+)) have a high risk postoperative recurrence, despite curative resection after preoperative therapy. Subclinical micrometastases are...
We previously reported that serum hepatocyte growth factor (HGF) levels are elevated in patients with acute pancreatitis and pancreatitis-associated ascitic fluid (PAAF) contains cytotoxic factor(s) inducing apoptosis on Madin–Darby canine kidney (MDCK) cells. In this study, plasma HGF tissue distribution were investigated rats experimental pancreatitis, the effects of activity apoptosis-inducing PAAF also examined. Plasma two models different grades severity. The degree its elevation was...
The effect of gastrectomy on the subsequent development esophageal cancer was investigated. Duodenogastroesophageal reflux is thought to be common in patients after distal gastrectomy, but whether this contributes such controversial. We retrospectively evaluated 153 who underwent subtotal esophagectomy for thoracic between January 2002 and July 2005. They were divided into two groups, according or not they had previously undergone a gastrectomy: group 1, comprising 14 2, 139 not. Clinical...
Aim: To conduct a phase II study of single intraperitoneal (i.p.) administration paclitaxel followed by paclitaxel, cisplatin, and S-1 (PCS) chemotherapy for patients with gastric cancer peritoneal metastasis (PM). Patients Methods: Staging laparotomy was performed to confirm PM. Initially, received i.p. paclitaxel. Beginning 7 days later, PCS given every 3 weeks second-look laparoscopy. Primary secondary endpoints were the overall survival (OS) rate, response rate patient safety,...
Summary We aimed to determine the frequency and prognosis of supraclavicular (#104) lymph node (LN) metastasis compared with other LN stations in patients advanced thoracic esophageal cancer identify risk factors for delineate indications three-field lymphadenectomy (3FL). The study cohort 567 eligible had undergone subtotal esophagectomy from 2003 2020. was defined as pathologically proven or positron emission tomography-positive LNs. efficacy index (EI), calculated metastases survival...