A5047356970- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Clinical Nutrition and Gastroenterology
- Estrogen and related hormone effects
- Synthesis of β-Lactam Compounds
- Gastrointestinal Tumor Research and Treatment
- Melanoma and MAPK Pathways
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Gastrointestinal disorders and treatments
- Multiple and Secondary Primary Cancers
- Advancements in Photolithography Techniques
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
Kindai University
2023-2025
Osaka University
2008-2024
The University of Texas MD Anderson Cancer Center
2022-2023
Kinan Hospital
2022-2023
AntiCancer (United States)
2020
Osaka National Hospital
2014-2017
Osaka Dental University
2008
Kitasato Institute Hospital
2001
Canon (Japan)
1996-2000
Abstract Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. CD74 (sCD74) has been identified sera inflammatory diseases and implicated their pathophysiology; however, few relevant data are available the context cancer. Here we assessed composition production mechanisms, as well clinical significance biological properties, sCD74 melanoma. Serum levels were significantly elevated advanced melanoma patients compared with normal healthy donors, high...
Abstract CXCL9, an IFN‐γ inducible chemokine, has been reported to play versatile roles in tumor‐host interrelationships. However, little is known about its role intrahepatic cholangiocarcinoma (iCCA). Here, we aimed elucidate the prognostic and biological implications of CXCL9 iCCA. Endogenous expression number tumor‐infiltrating lymphocytes were immunohistochemically assessed resection specimens. These data validated mice treated by silencing with short hairpin RNA. In addition, induction...
Angiomyolipoma (AML) arising in the liver is rare and usually benign, but it occasionally has malignant potential. A 58-year-old man with a tumor identified by previous doctor features suggestive of hepatocellular carcinoma on computed tomography (CT) underwent anterior segmentectomy 2006. Microscopically, was composed exclusively epithelioid cells that were scatteredly positive for human melanoma black 45 immunohistochemistry. Accordingly, primary hepatic AML (eAML) diagnosed. The patient...
The use of elastic emission machining (EEM) for fabricating optics from low-thermal-expansion glass extreme ultraviolet (EUV) lithography is examined. EUV require figure accuracy and surface roughness 0.1nm root mean square (rms) or better. EEM using a rotating-sphere head demonstrated to achieve this level smoothness after certain depth removal dependent on the material being processed. In tests continuous 12h, no increase in observed, demonstrating high temporal stability noncontact...
Organic gases cause carbon depositions on the multi-layer mirrors by Extreme Ultra Violet (EUV) light irradiations in EUV lithography tool. The dependences organic gas species, pressure and intensity deposition were researched order to understand this reaction. was irradiated a (Si/Mo) multilayer mirror sample injecting like buthane, buthanol, methyl propionate, hexane, perfluoro octane, decane, decanol, nonanoate, diethyl benzene, dimethyl phthalate hexadecane. X-ray photoelectron...
Islet transplantation is an effective replacement therapy for type 1 diabetes (T1D) patients. However, shortage of donor organ allograft obstacle further development the treatment. Subcutaneous with stem cell-derived β-cells might overcome this, but poor vascularity in site burden success transplantation. We investigated effect subcutaneous vascularized β-cell spheroid tissue constructed 3-dimensionally using a layer-by-layer (LbL) cell-coating technique T1D model mouse.We used MIN6 cells to...
Abstract Purpose Iatrogenic gallbladder perforation frequently occurs during laparoscopic cholecystectomy and may increase the risk of infectious complications. The effectiveness postoperative antibiotics drainage in preventing infections remain unclear. study aimed to investigate clinical outcomes patients with relation these treatments. Methods One hundred twenty-one consecutive were enrolled. Surgeons chose treatments for perforation: (n = 48), 39), no treatment 34). Infectious...
The arachidonic acid pathway participates in immunosuppression various types of cancer. Our previous observation detailed that microsomal prostaglandin E2 synthase 1 (mPGES-1), an enzyme downstream cyclooxygenase 2 (COX-2), limited antitumor immunity melanoma; addition, genetic depletion mPGES-1 specifically enhanced immune checkpoint blockade therapy. current study set out to distinguish the roles from those COX-2 tumor and determine potential inhibitors for reinforcing immunotherapy...
Background: The aim of this study was to identify predictors high-output stoma (HOS) after low anterior resection (LAR) with diverting ileostomy for rectal cancer. Methods: medical records 60 patients who underwent LAR cancer between 2012 and 2015 were reviewed. HOS defined as output greater than 1500 mL per 24 hours. Patient surgical characteristics patient laboratory data examined assess using univariate multivariate logistic regression. Results: incidence 43.3% (26/60). In analysis, age ≥...