A5100663856- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Synthesis of β-Lactam Compounds
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Receptor Mechanisms and Signaling
- Melanoma and MAPK Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Plant Molecular Biology Research
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Nitrogen and Sulfur Effects on Brassica
- Pediatric Hepatobiliary Diseases and Treatments
- NF-κB Signaling Pathways
- Click Chemistry and Applications
- RNA modifications and cancer
- Nicotinic Acetylcholine Receptors Study
- Lipid metabolism and biosynthesis
The University of Texas MD Anderson Cancer Center
2011-2024
Kookmin University
2010-2014
Pohang University of Science and Technology
2002-2014
National Academy of Agricultural Science
2012
Jeonbuk National University
2010-2011
Melanoma Institute Australia
2003-2010
Kyung Hee University
2009
Chonnam National University
2008
Sungkyunkwan University
2005
Abstract Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to paucity of T cells within the tumor microenvironment (TME). However, it is also possible while neoantigens are present, an effective immune response cannot be generated due suppressive TME. To discern whether targetable exist in PDAC, we performed comprehensive study using genomic profiles 221 PDAC cases extracted from public...
Prostaglandin E(2) (PGE(2)), the most abundant COX-2-derived prostaglandin found in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling pathways. However, role of PGE(2) hypoxia is not well understood. Here, we show a synergistic effect on enhancing angiopoietin-like protein 4 (ANGPTL4) expression that elevation ANGPTL4 cancer growth. induces at both mRNA levels under hypoxic conditions. Moreover, one receptors, namely EP1. Activation EP1 enhances...
Curcuma longa has been commonly used as a traditional remedy for variety of symptoms such inflammation, gastritis and gastric ulcer. When C. extract was administered per os to pylori-ligated rat stomachs, it reduced acid secretion protected against the formation mucosal lesions. We therefore tested whether inhibits ulcers by blocking H2 histamine receptor. Dimaprit, receptor agonist, induced intracellular cAMP production in U937 HL-60 promyelocytes. Pretreatment with significantly blocked...
Microsomal prostaglandin E2 synthase 1 (mPGES1) was evaluated as an important downstream effector of the COX2 pathway responsible for tumor-mediated immunosuppression in melanoma.The analysis a stage III melanoma tissue microarray (n = 91) performed to assess association between mPGES1, COX2, CD8, and patient survival. Pharmacologic inhibitors syngeneic mouse models using PTGES-knockout (KO) cell lines were used evaluate mPGES1-mediated immunosuppressive function.We observed correlations...
Lysophosphatidic acid (LPA) activates a family of cognate G protein-coupled receptors and is involved in various pathophysiological processes.However, it not clearly understood how these LPA are specifically coupled to their downstream signaling molecules.This study found that 2 , but the other receptor isoforms, interacts with Na ؉ /H exchanger regulatory factor2 (NHERF2).In addition, interaction between them requires C-terminal PDZ domain-binding motif second domain NHERF2.Moreover, stable...
Krüppel-like factor 12 (KLF12) is a transcription that plays role in normal kidney development and repression of decidualization. KLF12 frequently elevated esophageal adenocarcinoma has been reported to promote gastric cancer progression. Here, we examined the colorectal (CRC). Indeed, promotes tumor growth by directly activating early response protein 1 (EGR1). The levels EGR1 correlate synergistically with poor prognosis. These results indicate likely an important CRC could serve as...
<p>Figure S1, Figure S2, FIgure S3, S4, S5, S6, S7, S8</p>
<div>AbstractPurpose:<p>Biliary tract cancers, which are rare and aggressive malignancies, rich in clinically actionable molecular alterations. A major challenge the field is paucity of relevant biliary cancer models that recapitulate diverse profiles these tumors. The purpose this study was to curate a collection patient-derived xenograft (PDX) reflect spectrum genomic alterations present cancers create resource for modeling precision oncology.</p>Experimental...
Abstract Human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) is a scaffolding protein that implicated in regulating diverse cellular processes, such attachment, motility, cell cycle progression, apoptosis, and inflammation. Here, we identify HEF1 novel hypoxia-inducible factor-1α (HIF-1α)–regulated gene reveal mediates hypoxia-induced migration colorectal carcinoma cells. highly expressed cultured cells exposed to hypoxia the hypoxic areas human cancer (CRC) specimens....
Objective— Aberrant regulation of the proliferation, survival, and migration endothelial cells (ECs) is closely related to abnormal angiogenesis that occurs in hypoxia-induced pathological situations, such as cancer vascular retinopathy. Hypoxic conditions subsequent upregulation hypoxia-inducible factor-1α target genes are important for angiogenic functions ECs. Phospholipase D2 (PLD2) a crucial signaling mediator stimulates production second messenger phosphatidic acid. PLD2 involved...
Angiogenesis is essential for tumor growth and vascular endothelial cell factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) biologically active sphingolipid known to play cancer progression by regulating proliferation migration. In study, the authors found that S1P increases level of VEGF mRNA human umbilical vein cells (HUVECs) immortalized HUVECs (iHUVECs). Additionally, was increase promoter activity MS-1 mouse pancreatic islet cells. Furthermore,...
Poly-gamma-glutamic acid (γ-PGA) is a mucilaginous and biodegradable compound produced by Bacillus subtilis from fermented soybeans, found in the traditional Korean soy product, cheongkukjang.This study was carried out to evaluate effects of γ-PGA food source on concentration neurotransmitter GABA its metabolic precursor glutamate diet-induced obese rats.Eight-week old male Sprague-Dawley rats (n=60) were used.The divided into two groups obesity induced providing either 10% control fat or...