A5019625692- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Clinical Nutrition and Gastroenterology
- Renal cell carcinoma treatment
- Advanced Glycation End Products research
- Nutrition and Health in Aging
- Glycosylation and Glycoproteins Research
- Diabetes Management and Research
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Supramolecular Self-Assembly in Materials
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes and associated disorders
- Cancer Genomics and Diagnostics
- Proteoglycans and glycosaminoglycans research
Osaka University
2021-2025
We investigated the potential of adipose-derived stem cells (ADSCs) in preventing post-hepatectomy liver failure, emphasizing necessity direct administration using a scaffold. A fibrin gel scaffold was employed for ADSCs (gelADSC) to assess their therapeutic impact on regeneration both vitro and vivo settings. Experiments were conducted C57BL/6 mice with normal livers those chronic hepatitis. also explored role extracellular vesicles (EVs) secreted by conjunction gel. GelADSC showed...
Abstract Aim Decreasing intraoperative blood loss is one reported advantage of laparoscopic surgery compared with open surgery. However, several reports indicate that during may be underestimated. No studies have evaluated this possibility in distal pancreatectomy (LDP). Here we estimated (e‐BL) to (i‐BL) (DP). Methods This study included 114 patients undergoing DP our institution the period. We examined relationship between i‐BL and e‐BL. Based on these results, further investigated LDP....
Abstract Cholangiocarcinoma is a highly malignant cancer. Many patients need systemic chemotherapy to prevent tumor development and recurrence; however, their prognosis poor due the lack of effective therapy. Therefore, new treatment option urgently required. We recently identified glypican-1 (GPC1) as novel cancer antigen esophageal squamous cell carcinoma. also demonstrated efficacy safety GPC1-targeted ADC (GPC1–ADC) conjugating anti-GPC1 mAb possessing high internalization activity with...
Abstract Purpose Postoperative pancreatic fistula is a serious complication of distal pancreatectomy. Although many studies have described the incidence and risk factors associated with postoperative (POPF), few focused on healing time. This study investigated time potential POPF after pancreatectomy (DP). Methods Among 114 patients that underwent DP in our hospital from January 2010 to December 2020, we included 88 developed POPF. The for was defined as interval between completion removal...
Background. No effective therapies have yet been established for liver regeneration in failure. Autologous skeletal myoblast cell sheet transplantation has proven to improve cardiac function patients with heart failure, and one of the mechanisms reported be a paracrine effect by various growth factors associated regeneration. Therefore, present study focused on cells vitro vivo. Methods. We assessed comprising association In addition, we examined vivo C57/BL/6 mouse models such as fibrosis...
Islet transplantation is an effective replacement therapy for type 1 diabetes (T1D) patients. However, shortage of donor organ allograft obstacle further development the treatment. Subcutaneous with stem cell-derived β-cells might overcome this, but poor vascularity in site burden success transplantation. We investigated effect subcutaneous vascularized β-cell spheroid tissue constructed 3-dimensionally using a layer-by-layer (LbL) cell-coating technique T1D model mouse.We used MIN6 cells to...
<title>Abstract</title> We investigated the potential of adipose-derived stem cells (ADSCs) in preventing post-hepatectomy liver failure, emphasizing necessity direct administration using a scaffold to harness their paracrine effects. A fibrin gel was employed for ADSCs (gelADSCs) assess therapeutic impact on regeneration both vitro and vivo settings. Experiments were conducted C57BL/6 mice with normal livers those chronic hepatitis. also explored role extracellular vesicles (EVs) secreted...
Objective: Percutaneous transhepatic gallbladder aspiration (PTGBA) and/or drainage (PTGBD) are useful approaches in the management of acute cholecystitis patients who cannot tolerate surgery because poor general condition or severe inflammation. However, reports regarding its effect on surgical outcomes subsequent laparoscopic cholecystectomy (LC) sparse. The aim this retrospective study was to investigate influence PTGBA LC by comparing only-PTGBA group, including did not need...
Abstract Purpose Decreasing intraoperative blood loss is one reported advantage of laparoscopic surgery compared with open surgery. However, several reports indicate that during may be underestimated. No studies have evaluated this possibility in distal pancreatectomy (LDP). Here we estimated (e-BL) to actual (i-BL) (DP). Methods This study included 114 patients undergoing DP our institution the period. We examined relationship between i-BL and e-BL. Based on these results, further...