A5064635823- Acute Ischemic Stroke Management
- Mesenchymal stem cell research
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenesis and neuroplasticity mechanisms
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Barrier Structure and Function Studies
- Lipoproteins and Cardiovascular Health
- Vascular Anomalies and Treatments
- Renal and Vascular Pathologies
- Management of metastatic bone disease
- Connective tissue disorders research
- Spinal Hematomas and Complications
- Cervical and Thoracic Myelopathy
- Cerebral Venous Sinus Thrombosis
Hyogo University
2022-2024
Hyogo Medical University
2014-2024
Tokyo Metropolitan Neurological Hospital
2017
St. Luke's International Hospital
2017
Oita University Hospital
2017
Osaka City General Hospital
2017
University of Tsukuba
2017
The purpose of this study is to compare the angiographic and clinical characteristics spinal epidural arteriovenous fistulas (SEAVFs) dural (SDAVFs) thoracolumbar spine.A total 168 cases diagnosed as or extradural spine were collected from 31 centers. Angiography findings, including symptoms, sex, history surgery/trauma, retrospectively reviewed. Angiographic images evaluated, with a special interest in levels, feeders, shunt points, shunted pouch its location, drainage pattern, by 6 readers...
Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced cells (iSCs) can contribute to neurogenesis. However, it is essential understand traits iSCs poststroke human for possible applications cell-based therapies stroke patients. In this study, we report first time be isolated from brain. Putative were derived tissue obtained...
Background and Purpose— Several studies suggested that statins during hospitalization were associated with better disability outcomes in patients acute ischemic stroke, but only 1 small randomized trial is available. Methods— We conducted a multicenter, open-label, controlled strokes 11 hospitals Japan. Patients stroke dyslipidemia randomly received within 24 hours after admission the early group or on seventh day delayed group, 1:1 ratio. Statins administered for 12 weeks. The primary...
Neuro-inflammation plays a key role in the pathophysiology of brain infarction. Cell therapy offers novel therapeutic option due to its effect on immunomodulatory effects. Amniotic stem cells, particular, show promise owing their low immunogenicity, tumorigenicity, and easy availability from amniotic membranes discarded following birth. We have successfully isolated expanded human mesenchymal cells (hAMSCs). Herein, we evaluated hAMSCs neurological deficits after infarction as well effects...
There is compelling evidence that the mature central nervous system (CNS) harbors stem cell populations outside conventional neurogenic regions. We previously demonstrated brain pericytes (PCs) in both mouse and human exhibit multipotency to differentiate into various neural lineages following cerebral ischemia. PCs are found throughout CNS, including cerebellum, but it remains unclear whether cerebellar also form ischemia-induced multipotent cells (iSCs). In this study, we demonstrate...
Intramedullary spinal cord tumors (IMSCTs) are uncommon and difficult to treat. Studies examining the efficacy of rare IMSCT surgery in elderly limited. We conducted a subanalysis using multicenter retrospective-historical data provided by Japan Neurospinal Society compare surgical outcomes between older younger adults with IMSCTs.We classified patients IMSCTs into (aged 18-64 years) or ( ≥ 65 groups. The primary "improved" "worsened" from preoperative period 6 months after were evaluated...
This study aimed to analyze the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients from 2022 Neurospinal Society Japan multicenter intramedullary spinal cord tumor study.
Background Hemorrhagic transformation after recanalization is a severe complication in patients with large ischemic core due to cerebral vessel occlusion. Risk assessment using perfusion imaging predict hemorrhagic infarction has not been established. Thus, we aimed investigate the association between findings and acute occlusion who had undergone preoperative evaluation mechanical thrombectomy. Methods We enrolled consecutive received thrombectomy undergoing for anterior from May 2019 March...
Preoperative angiography in glioblastoma (GBM) often shows arteriovenous shunts and early venous filling (EVF). Here, we investigated the clinical implications of EVF GBM as a prognostic vascular mimicry biomarker. In this retrospective multicenter study, consecutively enrolled patients who underwent with diagnosis between April 1, 2013, March 31, 2021. The primary secondary endpoints were differences overall survival (OS) progression-free (PFS), respectively, cases without EVF. Of 133...
Objective: The objective of this study was to clarify the current status endovascular thrombectomy for acute ischemic stroke due large vessel occlusion in Japan.
This chapter outlines the cerebrovascular developmental anatomy with emphasis on internal carotid artery(ICA), which is important for optimal endovascular treatment of system disorders. Gene expression, neural crest cells, and pharyngeal arches play key roles in embryonic development arteries. Evolutionary inheritance vertebrates contributes to formation, regression, segmental structure these We present examples current mutations regard their nature; ICA are discussed primarily origin from...
<b><i>Introduction:</i></b> The management and prognosis of acute ischemic stroke due to multiple large-vessel occlusion (LVO) (MLVO) are not well scrutinized. We therefore aimed elucidate the differences in patient characteristics MLVO single LVO (SLVO). <b><i>Methods:</i></b> Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism Japan Registry 2 (RESCUE-Japan 2) enrolled 2,420 consecutive patients with who were admitted within 24...
Cervical dumbbell schwannomas are commonly occurring tumor in the cervical spine. Careful planning of surgical strategy is necessary to achieve successful resection while maintaining spinal stability and preventing any adverse events. We describe management for obtaining safe gross total schwannomas. The role preoperative embolization importance multi-axis angiography unit supporting this procedure has also been described. Informed consent was obtained case reporting. A 23-year-old male with...
Convexity dural arteriovenous fistula (dAVF) is associated with high-grade dAVF and usually presented aggressive clinical presentation. Precise diagnosis understanding the pathogenesis are important to achieving successful treatment without complications. We report a case of Sylvian-Labbé collateral pattern, concerning embryological development that was thought be involved in vascular architecture AVF. Thus, 60-year-old man sudden onset seizure no history trauma. Magnetic Resonance Imaging...
Preoperative angiography in glioblastoma (GBM) often shows arteriovenous shunts and early venous filling (EVF). Here, we investigated the clinical implications of EVF GBM as a prognostic vascular mimicry biomarker. In this retrospective multicenter study, consecutively enrolled patients who underwent with diagnosis between 1 April 2013 31 March 2021. The primary secondary endpoints were differences overall survival (OS) progression-free (PFS), respectively, cases without EVF. Of 133...
The aim of this study was to compare the accuracy, safety, and usefulness percutaneous pedicle screw (PPS) placement for lumbar fixation using a multi-axis angiography unit (MAU) an electronic conductivity device (ECD) with cannulated Jamshidi needle that conventional C-arm. Of 65 cases underwent (region between L1-S1) during April 2013 March 2019, 57 could be followed-up more than 12 months after procedure were included. Among them, 31 patients (150 screws) received treatment MAU ECD...
【目的】両側上小脳動脈硬膜枝を流入動脈とした小脳テント硬膜動静脈瘻の1 例を報告する．【症例呈示】74 歳男性，呂律困難，嘔吐で発症．小脳出血，くも膜下出血を認め，両側上小脳動脈硬膜枝を流入動脈とした小脳テント硬膜動静脈瘻からの出血と診断した．シャントポイントが正中側に存在したため，まず経動脈的塞栓術を施行し，シャントの残存に対して，外科的手術を追加し，根治を得た．【結論】本症例は両側上小脳動脈硬膜枝のみを流入血管とする極めて稀な硬膜動静脈瘻であることが手術的にも確認された．上小脳動脈硬膜枝の認知の重要性と血管内治療の可能性について考察する．
Abstract Background Hemorrhagic transformation (HT) after recanalization is a severe complication in patients with large ischemic core due to cerebral vessel occlusion. Risk assessment using perfusion imaging predict hemorrhagic infarction has not been established. Thus, we aimed investigate the association between findings and HT acute occlusion who had undergone preoperative evaluation mechanical thrombectomy. Methods We enrolled consecutive received thrombectomy (MT) undergoing for...
我々が行っている急性期脳梗塞の予後改善を目指した基礎・臨床研究とその展望を紹介する．1）血栓回収療法普及プロジェクト（RESCUE-Japan Project）：本治療の有効性は確立したが，未だ十分に普及していない．このため，全国調査の結果をもとに，治療の推進に取り組んでいる．2）救急隊用脳卒中病型予測スコア開発：脳梗塞患者の予後改善のためには迅速かつ適切な搬送が必須である．我々が開発したこのアプリケーションは診断率が高く，救急搬送に応用していく．3）急性期脳梗塞および頸部・頭蓋内動脈狭窄に対する脂質低下療法に関する臨床試験：スタチンを用いた研究をベースにPCSK-9 阻害薬を用いた研究を開始する予定である．4）急性期脳梗塞に対する細胞療法の基礎・臨床研究：梗塞後の機能回復を目指した再生医療研究として，骨髄単核球，傷害誘導性多能性幹細胞，羊膜由来間葉系幹細胞を用いた臨床研究を行う予定である．
We have previously demonstrated that brain pericytes near cerebral vessels acquired multipotency following ischemia in mice, and these ischemia-induced multipotent stem cells (iSCs) could contribute to neurogenesis (Nakagomi et al. Eur J Neurosci. 2009, Stem Cells. 2015). However, it remains unclear whether can also revert the human stroke. The study protocol was approved by Ethics Committee of Hyogo College Medicine. Brain samples were obtained from post-stroke areas patients requiring both...