A5033102918- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Angiogenesis and VEGF in Cancer
- Acute Ischemic Stroke Management
- Inflammatory mediators and NSAID effects
- Protease and Inhibitor Mechanisms
- Gallbladder and Bile Duct Disorders
- Spinal Dysraphism and Malformations
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related Molecular Pathways
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Intracerebral and Subarachnoid Hemorrhage Research
- Cervical and Thoracic Myelopathy
- Appendicitis Diagnosis and Management
- Neuropeptides and Animal Physiology
- Genomic variations and chromosomal abnormalities
- Spinal Fractures and Fixation Techniques
- Immune cells in cancer
- Histiocytic Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Antibiotic Use and Resistance
- Tryptophan and brain disorders
Kyoto University
1970-2024
Hyogo Prefectural Amagasaki General Medical Center
2019-2024
Cosmo Oil (Japan)
2024
International Rescue System
2022
Japan Community Healthcare Organization
2021
Osaka Hospital
2021
Kobe University
2016-2020
Kobe Institute Of Computing
2019
Japan Society for the Promotion of Science
2017
Murata (Japan)
2016-2017
Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due large-vessel occlusion. However, the extent of ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit efficacy EVT.To compare and safety EVT according ASPECTS 3 or less vs 4 5.The Recovery by Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted...
Background Chronic inflammation plays a key role in the pathogenesis of intracranial aneurysms ( IA s). DPP‐4 (dipeptidyl peptidase‐4) inhibitors have anti‐inflammatory effects, including suppressing macrophage infiltration, various inflammatory models. We examined whether DPP ‐4 inhibitor, anagliptin, could suppress growth s rodent aneurysm model. Methods and Results were surgically induced 7‐week‐old male Sprague Dawley rats, followed by oral administration 300 mg/kg anagliptin. measured...
With increasing body weight, macrophages accumulate in adipose tissue. There, activated secrete numerous proinflammatory cytokines and chemokines, giving rise to chronic inflammation insulin resistance. Prostaglandin E2 suppresses macrophage activation via EP4; however, the role of EP4 signaling resistance type 2 diabetes mellitus remains unknown. In this study, we treated db/db mice with an EP4-selective agonist, ONO-AE1-329, for 4 weeks explore obesity-related vivo. Administration agonist...
Abstract Water production management is a common concern for oil fields adopting water flooding. shut-off (WSO) technologies: both mechanical and chemical methods have been investigated to mitigate increasing production. Mechanical like cementing or by completion types work within the wellbore. Crosslink polymer gels as method penetrate maximum 10 ft from wellbore in most cases. Hence, crossflow inside reservoir considered potential risk deteriorate WSO impact on improvement. This paper...
Gefitinib, a selective epidermal growth factor receptor tyrosine kinase inhibitor, is an effective treatment for patients with non-small cell lung cancer (NSCLC). Some investigators have recently reported several complicated by acute injury after the initiation of gefitinib administration. In this report, we investigated efficacy and adverse events during gefitinib. The subjects study were all 110 NSCLC who treated in our hospital its eight branch hospitals. Patients received at dose 250 mg...
Objective- Atherosclerosis is a common disease caused by variety of metabolic and inflammatory disturbances. MicroRNA (miR)-33a within SREBF2 (sterol regulatory element-binding factor 2) potent target for treatment atherosclerosis through regulating both aspects; however, the involvement miR-33b SREBF1 remains largely unknown. Although their host genes difference could lead to functional divergence miR-33a/b, we cannot dissect roles miR-33a/b in vivo because lack sequences mice, unlike...
Background Chronic inflammation through cellular senescence, known as the senescence-associated secretory phenotype, is a mechanism of various organ diseases, including atherosclerosis. Particularly, ionizing radiation (IR) contributes to senescence by causing DNA damage. Although previous clinical studies have demonstrated that radiotherapy causes atherosclerosis long-term side effect, detailed unclear. This study was conducted investigate relationship between radiation-induced and...
Tenofovir, one of antiretroviral medication to treat human immunodeficiency virus (HIV) infection, is known cause proximal renal tubular acidosis such as Fanconi syndrome, but cases distal had never been reported. A 20-year-old man with HIV infection developed nausea and vomiting without diarrhea after starting therapy. Arterial blood gas revealed non-anion-gap metabolic urine test showed positive anion gap. medicine the patient received, was considered be this all drugs were discontinued....
Background Carotid plaques with expansive arterial remodeling are closely related to cerebral ischemic events. Although S100A4 (S100 calcium-binding protein A4) is expressed in atherosclerotic lesions, its role plaque progression remains unknown. In this study, we examined the association between carotid and expression. Methods Results Preoperative high-resolution magnetic resonance imaging was used assess luminal stenosis vascular patients undergoing endarterectomy. To examine murine...
Atherosclerotic burden increases the risk of both extracranial internal carotid artery stenosis (ICS) and intracranial large disease (ICAD). However, differences in profiles have not been thoroughly investigated.
A 72-year-old man presented to our hospital with a fever. Chest computed tomography showed typical coronavirus disease 2019 (COVID-19) pneumonia. The fever normalized after few days, and the pneumonia was alleviated. However, intermittent subsequently re-occurred persisted for over month. Various tests, including blood culture image evaluations, were performed. conclusion that long COVID cause of as an exclusion diagnosis. Many patients suffer from persistent symptoms COVID-19, but their...
Zinc is an essential micronutrient with multiple biological effects, including antiinflammation. Previously, the authors demonstrated that pathogenesis of intracranial aneurysms (IAs) strongly related to chronic inflammation. In this study, investigated whether administration zinc inhibits growth IAs in a rat model.
Aim: In patients with carotid plaque, intraplaque hemorrhage arising from ruptured neovascular vessels within the neointima is an important cause of stroke. The expression Vasohibin-1 (VASH1), a negative feedback regulator angiogenesis, occurs in microvessel endothelial cells various solid tumors and arterial wall. However, roles VASH1 pathogenesis atherosclerotic diseases remain unclear. present study aimed to clarify relevance plaque instability human plaques.Methods: We used quantitative...