A5046208454- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Sensor Technology and Measurement Systems
- Cell Adhesion Molecules Research
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Optical Coherence Tomography Applications
- Cancer Immunotherapy and Biomarkers
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
Aix-Marseille Université
2015-2025
KU Leuven
2016-2025
Inserm
2015-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Universitair Ziekenhuis Leuven
2007-2024
Radboud University Medical Center
2024
Leiden University Medical Center
2024
Radboud University Nijmegen
2024
University Medical Center Utrecht
2024
Erasmus MC
2024
The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has been well studied.In a randomized, controlled trial, we assigned subgroup were undergoing TAVI did anticoagulation, 1:1 ratio, to receive aspirin alone or plus clopidogrel 3 months. two primary outcomes all (including minor, major, life-threatening disabling...
The roles of anticoagulation alone or with an antiplatelet agent after transcatheter aortic-valve implantation (TAVI) have not been well studied.We performed a randomized trial clopidogrel in patients undergoing TAVI who were receiving oral for appropriate indications. Patients assigned before 1:1 ratio to receive 3 months. two primary outcomes all bleeding and non-procedure-related over period 12 Procedure-related was defined as Bleeding Academic Research Consortium type 4 severe bleeding,...
Background— Drug eluting stents with durable polymers may be associated hypersensitivity, delayed healing, and incomplete endothelialization, which contribute to late/very late stent thrombosis the need for prolonged dual antiplatelet therapy. Bioabsorbable facilitate thus enhancing clinical safety. The SYNERGY is a thin-strut, platinum chromium metal alloy platform an ultrathin bioabsorbable Poly(D,L-lactide-co-glycolide) abluminal everolimus-eluting polymer. We performed multicenter,...
The neural cell adhesion molecules (N-CAM) occur chiefly in two molecular forms that are selectively expressed at various stages of development. Highly sialylated prevalent embryonic and neonatal brain gradually replaced by less as development proceeds. Here we describe a monoclonal antibody raised against the capsular polysaccharides meningococcus group B (Men B) which specifically distinguishes N-CAM from adult N-CAM. This recognizes alpha 2-8-linked N-acetylneuraminic acid units (NeuAc...
Recent publications have demonstrated the presence of tissue factor (TF)–bearing microparticles (MPs) in blood patients suffering from cancer. However, whether these MPs are involved thrombosis remains unknown. We show that pancreatic and lung cancer cells produce express active TF P-selectin glycoprotein ligand 1 (PSGL-1). Cancer cell–derived aggregate platelets via a TF-dependent pathway. In vivo, MPs, but not their parent cells, infused into living mouse accumulate at site injury reduce...
Adhesion of platelets to an injured vessel wall and platelet activation are critical events in the formation a thrombus. Of agonists involved activation, thrombin, collagen, vWF known induce vitro calcium mobilization platelets. Using calcium-sensitive fluorochrome digital multichannel intravital microscopy image unstimulated stimulated platelets, was monitored as reporter (as distinct from accumulation) during thrombus live mice. In absence vWF, normal, but adherence aggregation were...
Venous thromboembolism constitutes one of the main causes death during progression a cancer. We previously demonstrated that tissue factor (TF)-bearing cancer cell-derived microparticles accumulate at site injury in mice developing pancreatic The presence these thrombosis correlates with size platelet-rich thrombus. objective this study was to determine involvement TF expressed by on associated observed cell derived TF, its inhibitor pathway (TFPI) as well integrins αvβ1 and αvβ3. In bearing...
The platelet-rich plasma (PRP) is an autologous biotherapy based on platelet-healing properties. Here, we developed a simple and reproducible PRP purification protocol two successive centrifugations. We evaluated different centrifugation speeds time-storage durations the platelet quantity quality. Sterility stability of our homemade product were also performed. prepared from 54 healthy volunteers. tested activation state, reactivity, platelets by flow cytometry using basal adenosine...
Abstract Background Percutaneous treatment of coronary bifurcation lesions remains hampered by suboptimal results, mainly in the side branch (SB), even with use drug‐eluting stents (DES). Paclitaxel balloons (DEB) could provide an attractive alternative to treat bifurcations combination a provisional T‐stenting technique order minimize SB restenosis. We compared angiographic and clinical outcomes DEB plus bare‐metal stent (BMS) versus BMS paclitaxel DES. Methods In this randomized,...
Platelets promote metastasis, however, their role in tumor growth remains controversial. Here, we investigated the effect of platelet interactions with colorectal cells. extravasated into microenvironment and interacted cells a cadherin-6-dependent manner. The interaction induced spreading, release granule content, generation three types microparticles (iMP) that expressed markers, or both. presence iMPs was confirmed cancer tissue specimens. significantly reduced increased intratumoral...
Early studies of the Tendyne transcatheter mitral valve replacement (TMVR) showed promising results in a small selective cohort. The authors present 1-year data from currently largest commercial, real-world cohort originating investigator-initiated TENDER (Tendyne European Experience) registry. All patients registry eligible for follow-up were included. primary safety endpoint was cardiovascular mortality. Primary performance reduction regurgitation (MR) up to 1 year. Among 195 undergoing...