A5059398118- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet and metabolism studies
- Blood disorders and treatments
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Extracellular vesicles in disease
- Cardiovascular and exercise physiology
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nuts composition and effects
- Physical Activity and Health
- Cardiac tumors and thrombi
- Immune cells in cancer
- Potassium and Related Disorders
- Heat shock proteins research
- Healthcare Policy and Management
- Epilepsy research and treatment
- Genetic Associations and Epidemiology
- Radioactive Decay and Measurement Techniques
- Cardiac Structural Anomalies and Repair
Central Michigan University
2024
JSS Academy of Higher Education and Research
2023-2024
Creative Commons
2023
Aix-Marseille Université
2009-2022
Inserm
2007-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2022
Radiology Associates
2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2018
Grace (United States)
2018
St. Joseph’s Candler Hospital
2018
Recent publications have demonstrated the presence of tissue factor (TF)–bearing microparticles (MPs) in blood patients suffering from cancer. However, whether these MPs are involved thrombosis remains unknown. We show that pancreatic and lung cancer cells produce express active TF P-selectin glycoprotein ligand 1 (PSGL-1). Cancer cell–derived aggregate platelets via a TF-dependent pathway. In vivo, MPs, but not their parent cells, infused into living mouse accumulate at site injury reduce...
Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is increasing interest, their role still unclear. We analyzed a large aPL panel 157 patients with according to disease severity. also investigated potential association between and extracellular DNA (exDNA, n = 85) or circulating markers neutrophil traps (NET) such as citrullinated histones H3 (CitH3, 49). A total sera infected by SARS-CoV-2 were collected. including lupus anticoagulant, anti-cardiolipin anti-beta-2...
Bile salt-dependent lipase (BSDL) is an enzyme involved in the duodenal hydrolysis and absorption of cholesteryl esters. Although some BSDL transported to blood, role circulating unknown. Here, we demonstrate that stored platelets released upon platelet activation. Because contains a region structurally homologous V3 loop HIV-1, which binds CXC chemokine receptor 4 (CXCR4), hypothesized might bind CXCR4 present on platelets. In human vitro, both peptide corresponding its V3-like induced...
Genome wide association studies (GWAS) identified SLC44A2 as a novel susceptibility gene for venous thrombosis (VT) and previous work established that contributed to clot formation upon vascular injury.To further investigate the role of in VT by utilizing deficient mice (Slc44a2-/- ) two representative disease models.Mice were included hypercoagulability model driven siRNA-mediated hepatic silencing anticoagulants Serpinc1 (antithrombin) Proc (protein C) flow restriction (stenosis) induced...
Summary Recombinant tissue plasminogen activator (r-tPA) is the drug of choice for thrombolysis, but it associated with a significant risk bleeding and not always successful. By cleaving von Willebrand factor (VWF), metalloprotease ADAMTS13 (a disintegrin-like thrombospondin type I repeats-13) down-regulates thrombus formation in injured vessels. We investigated whether recombinant (r-ADAMTS13) induces thrombolysis vivo mice. Thrombosis was produced by ferric chloride-induced (FeCl3) injury...
The regulation of maternal mRNAs is essential for proper oogenesis, the production viable gametes, and to avoid birth defects infertility. Many oogenic RNA-binding proteins have been identified with roles in mRNA metabolism, some which localize dynamic ribonucleoprotein granules others that appear dispersed. Here, we use a combination vitro condensation assays vivo
Evidence for reducing cardiovascular and renal events with sotagliflozin is uncertain among type 2 diabetes mellitus (T2DM) patients. To gather more evidence, this meta-analysis assesses the beneficial effects of sotagliflozin, a dual sodium–glucose cotransporter 1 inhibitor, in diabetic patients or without chronic kidney disease (CKD). Scopus, Google Scholar, Cochrane Central Register Controlled Trials (CENTRAL), PubMed were databases used to search. The studies published from January 1,...
The regulation of maternal mRNAs is essential for proper oogenesis, the production viable gametes, and to avoid birth defects infertility. Many oogenic RNA-binding proteins have been identified with roles in mRNA metabolism, some which localize dynamic ribonucleoprotein granules others that appear dispersed. Here, we use a combination
Abstract Background 2‐(2‐Nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC) treatment of alkaptonuria (AKU) leads to increased blood tyrosine levels, causing skin issues and potentially sight‐threatening corneal keratopathy. Adherence dietary management NTBC‐induced tyrosinemia, a low‐protein diet with or without protein substitutes, can be difficult for patients. This 28‐day interventional study evaluated low casein glycomacropeptide (cGMP) substitute (TYR sphere)®, 20 g...