A5102908006- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Cancer, Hypoxia, and Metabolism
- Women's cancer prevention and management
- Colorectal Cancer Treatments and Studies
- Amino Acid Enzymes and Metabolism
- Zeolite Catalysis and Synthesis
- Clay minerals and soil interactions
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- AI in cancer detection
- Metal-Organic Frameworks: Synthesis and Applications
- Clinical Nutrition and Gastroenterology
- Cancer, Lipids, and Metabolism
- Boron Compounds in Chemistry
- Colorectal Cancer Screening and Detection
- Photodynamic Therapy Research Studies
- Artificial Intelligence in Healthcare and Education
- RNA modifications and cancer
VIB-KU Leuven Center for Cancer Biology
2020
Universidade do Estado do Pará
2019
University of Minho
2011-2018
Indiana University School of Medicine
2017
Fondazione IRCCS Istituto Nazionale dei Tumori
2012
Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY NaA) used as hosts encapsulation α-cyano-4-hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated both by diffusion liquid phase. These new systems, CHC@zeolite, characterized spectroscopic techniques (FTIR, 1H NMR, 13C 27Al solid-state MAS UV–vis), chemical analysis,...
Colorectal cancer (CRC) is one of the most common malignancies and a leading cause death worldwide. Most cells display high rates glycolysis with production lactic acid, which then exported to microenvironment by monocarboxylate transporters (MCTs). The main aim this study was evaluate significance MCT expression in comprehensive series primary CRC cases, lymph node hepatic metastasis. Expressions MCT1, MCT4, CD147 GLUT1 were studied human samples CRC, metastasis, immunohistochemistry. All...
Y and MOR zeolites were used as a host for the temozolomide (TMZ). presented toxicity to glioblastoma cancer cells in contrast MOR. Higher potentiation of TMZ was obtained with comparison free both<italic>in vitro</italic>and<italic>in vivo</italic>.
5-FU release profiles reveled to be dependent on the host structures. DDS led significant potentiation of effect in cancer cells.
Colorectal cancer is one of the most common malignancies and a leading cause death worldwide. Molecular markers may improve clinicopathologic staging provide basis to guide novel therapeutic strategies which target specific tumour-associated molecules according individual tumour biology; however, so far, no ideal molecular marker has been found predict disease progression. We tested Ki-67 proliferation in primary lymph node metastasis CRC. observed statistical significant difference between...
This paper presents the results of in vitro photodynamic therapy assays on RKO and HCT-15 cell lines. The envisaged implementation is autonomous medical microdevices, such as endoscopic capsules for clinical treatment several types gastrointestinal tract tumors. Because their very limited device volume, light fluence rate needed to destroy tumor cells should be minimized. Foscan or meta-tetra(hydroxyphenyl)chlorin (mTHPC) used a photosensitizer. experimental show that small amount mTHPC...
Background: Colorectal cancer (CRC) is the third most common and fourth frequent cause of death worldwide. Nonetheless, despite being a on which many epidemiological international studies have already been written, Portuguese data are scarce in particular there very few specific for Minho Region, traditionally recognized as high incidence area. Aim: Characterize CRC patients treated at Braga Hospital. Methods: Data regarding clinical preoperative diagnostic examinations, operative reports...
Background Tumour cells relies mostly on glycolysis to meet their energetic demands thus leading an overload of lactic acid, which must be exported the extracellular milieu, through monocarboxylate transporters (MCTs). Due upregulation in cancer, MCTs are currently seen as promising therapeutic targets cancer. Colorectal carcinoma (CRC) is second most common type cancer worldwide, being mainly a disease industrialized countries. Among chemotherapeutic agents used treatment CRC,...