A5096744528- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Lung Cancer Diagnosis and Treatment
California University of Pennsylvania
2025
University of Pennsylvania
2024
We present the results of a randomized, open-label pilot study investigating combination oral vancomycin and stereotactic body radiotherapy (SBRT) in early-stage non-small cell lung cancer (NSCLC). Our findings highlight vancomycin's safety, evidenced by absence Grade 3 or 4 adverse events, its potential to enhance antitumor efficacy SBRT. The observed enhancement is linked modulation gut microbiota, which triggers significant metabolic changes immune activation, thereby contributing...
Activated T cells undergo a metabolic shift to aerobic glycolysis support the energetic demands of proliferation, differentiation, and cytolytic function. Transmembrane glucose flux is facilitated by transporters (GLUT) that play vital role in cell reprogramming anti-tumour GLUT isoforms are regulated at level expression subcellular distribution. GLUTs also display preferential selectivity for carbohydrate macronutrients including glucose, galactose, fructose. GLUT5, which selectively...