A5001268948- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Immune cells in cancer
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Pharmacogenetics and Drug Metabolism
- Organ Transplantation Techniques and Outcomes
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Blood groups and transfusion
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Anesthesia and Sedative Agents
- Liver physiology and pathology
- Ginseng Biological Effects and Applications
- Chronic Kidney Disease and Diabetes
- S100 Proteins and Annexins
- Inflammatory Myopathies and Dermatomyositis
- Invertebrate Immune Response Mechanisms
- Phagocytosis and Immune Regulation
- Anesthesia and Neurotoxicity Research
Renji Hospital
2020-2025
Shanghai Jiao Tong University
2008-2025
Brown University
2025
Northeast Agricultural University
2021-2025
Providence VA Medical Center
2025
Jinan University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
Influenza infection and pneumonia are known to cause much of their mortality by inducing acute respiratory distress syndrome (ARDS), which is the most severe form lung injury (ALI). Angiotensin-converting enzyme 2 (ACE2), a negative regulator angiotensin II in renin-angiotensin system, has been reported have crucial role ALI. Downregulation ACE2 always associated with ALI or ARDS induced avian influenza virus, syndrome-coronavirus, syncytial virus sepsis. However, molecular mechanism...
Abstract The interactions between chiral nanomaterials and organisms are still challenging mysterious. Here, a nanodevice made of yolk–shell nanoparticles tetrahedron (UYTe), centralized with upconversion (UCNPs), was fabricated to induce autophagy in vivo. proposed displayed tunable circular dichroism (CD) signal when modified different enantiomers glutathione (GSH). Notably, UYTe showed significant chirality-dependent autophagy-inducing ability after d -GSH-modification because the...
Abstract Background and Aim Chronic inflammation links closely to insulin resistance lipid metabolism in nonalcoholic fatty liver disease (NAFLD). Macrophage M1 activation plays an important role the initiation continuing of pro‐inflammatory response NAFLD. Our study was investigate whether macrophage M1/M2 polarization switching would affect hepatic through modulation peroxisome proliferator‐activated receptor‐gamma (PPAR‐γ) activity vivo vitro . Methods RAW264.7 macrophages were treated...
Simultaneous detection of multitrace gas is still a challenge. Near-confocal cavity-enhanced Raman spectroscopy proposed and demonstrated for simultaneous multitracegas. With 200 mW incident laser, the excitation power >9 W forms at two foci near-confocal cavity owing to beam being reflected 50 times. High-power light greatly enhances sensitivity system. Using this cavity-enhancing technique, high-sensitivity mixture eight gases with same volume ratio has been achieved. This technique may be...
Many studies suggested shared psychological and neural representations for first-hand physical pain empathy others' pain, both of which depend strongly upon top-down controlled mechanisms such as attention. This study aimed to assess the interindividual variation in whether their relationship is dependent We recruited participants exhibiting high low sensitivity (HPS LPS), adopted paradigms involving attention directed toward or withdrawn from another. Relative LPS group, HPS group estimated...
Background: Acetaminophen (APAP)-induced liver injury (AILI) is a common cause of drug-induced (DILI).The mechanism underlying protection in AILI or DILI remains to be elucidated, and the role early growth response 1 (Egr1) potential mechanisms remain known.Methods: The Egr1 was studied both vivo vitro.Liver-specific Egr1-knockout (Egr1 LKO ) mice those overexpressing via tail vein injection Egr1-expressing adenovirus (Ad-Egr1) were utilized with AILI.Chromatin...
Abstract Pulmonary hypertension (PH) increases the mortality of preterm infants with bronchopulmonary dysplasia (BPD). There are no curative therapies for this disease. Lung endothelial carnitine palmitoyltransferase 1a (Cpt1a), rate‐limiting enzyme shuttle system, is reduced in a rodent model BPD. It unknown whether Cpt1a reduction causes pulmonary vascular (PV) remodeling. The latter can be result endothelial‐mesenchymal transition (EndoMT). Here, cell (EC)‐specific KO and WT mice (<12...
ABSTRACT The accumulation of amyloid plaques is a pathological hallmark Alzheimer's disease (AD), in which ADAM10, the α‐secretase that catalyzes APP and facilitates non‐amyloidogenesis pathway, plays an important role. We have previously reported expression copine‐7 (Cpne7) hippocampus APP/PS1 mice significantly upregulated by nicotine, whereas potential role CPNE7 AD remains largely unknown. Here, we report protein levels are decreased HEK293 cells stably expressing full‐length APP. shown...
Aberrant RNA splicing is tightly linked to diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we revealed that minor intron splicing, a unique and conserved processing event, largely disrupted upon the progression of steatohepatitis (MASH) in mice humans. We demonstrated deficiency induces MASH transition obesity-induced insulin resistance LXR activation. Mechanistically, inactivation leads retention Insig1 Insig2, resulting premature termination...
ABSTRACT Drug‐induced liver injury (DILI) is a drug‐induced disease that not only complicates the treatment of primary but may also lead to acute failure or even death in severe cases. Drugs commonly used care, such as anti‐infective agents and nonsteroidal anti‐inflammatory drugs, are major causes DILI. In addition, large elderly population, comorbidities, combination therapy with multiple drugs increase risk DILI care. Therefore, care providers should proactively screen monitor high‐risk...
Indoleamine 2, 3-dioxygenase (IDO) is a potent immunoenzyme found in dendritic cells (DCs). Research has demonstrated that Trichinella spiralis induces IDO expression the host immune response through its excretory-secretory (ES) antigens. However, role of to T. remains unclear. To examine effects ES antigens on DCs vitro , assessments were conducted using qRT-PCR, Western blotting (WB), flow cytometry, and siRNA transfer. The findings indicated antigen stimulation upregulated . Furthermore,...
AIM To study the relationship between ABO blood groups and carcinoma of esophagus cardia in Chaoshan inhabitants China, which is a unique Littoral high-risk area esophageal China.The poor communication transportation past has made relatively closed kept its culture custure old China thousand years ago.METHODS Data on age, sex, type X-ray or patholog ical diagnose patients with were collected from Tumor Hospital.First
As a mechanically condensed product of Coleman fat, extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) eliminates adipocytes, concentrates SVF cells, and improves fat graft retention. This study aims to compare cell composition between ECM/SVF-gel. Matched ECM/SVF-gel 28 healthy women were subjected RNA-seq, followed by functional enrichment cell-type-specific analyses, deconvolution subsets, reconstructing in the transcriptome level. ECM/SVF-gels had 9 upregulated 73...
Abstract Background & Aims Macrophages display remarkable plasticity and can interact with surrounding cells to affect hepatic immunity tissue remodelling during the progression of liver diseases. Peroxisome proliferator‐activated receptor gamma (PPARγ) plays a critical role in macrophage maturation, polarization metabolism. In this study, we investigated PPARγ macrophage–hepatic stellate cell (HSC) interaction non‐alcoholic steatohepatitis (NASH) development. Methods Wild‐type, Pparg...