A5036719327- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Radiopharmaceutical Chemistry and Applications
- Blood groups and transfusion
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer therapeutics and mechanisms
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Head and Neck Surgical Oncology
- Synthesis and Characterization of Heterocyclic Compounds
- Salivary Gland Tumors Diagnosis and Treatment
- Blood transfusion and management
Southern University of Science and Technology
2023
Shantou University
2013-2022
Cancer Hospital of Shantou University Medical College
2013-2022
Hahnemann University Hospital
1993-2015
Shantou University Medical College
2004-2008
Linyi People's Hospital
2007
Shandong First Medical University
2006
Medical Research Foundation
2004
First Affiliated Hospital of Shantou University Medical College
2004
Jilin Province Tumor Hospital
2001
// Jianzhou Chen 1, 2, * , Hong Guo Tiantian Zhai 1 Daniel Chang 3 Zhijian 4 Ruihong Huang Wuzhe Zhang Kun Lin 5 Longjia Mingzhen Zhou Dongsheng Li Derui Chuangzhen Department of Radiation Oncology, Cancer Hospital Shantou University Medical College, Shantou, Guangdong, China 2 CRUK/MRC Oxford Institute for Oxford, United Kingdom Stanford University, Stanford, CA, USA The Hongkong - Shenzhen Hospital, Shenzhen, Public Health and Preventive Medicine, These authors have contributed equally to...
We aimed to develop a combined predicting model for benign esophageal stenosis (BES) after simultaneous integrated boost (SIB) with concurrent chemotherapy in patients squamous cell carcinoma (ESCC). This study included 65 EC who underwent SIB chemotherapy. Esophageal was evaluated using esophagograms and the severity of eating disorders. Risk factors were investigated univariate multivariate analyses. Radiomics features extracted based on contrast-enhanced CT (CE-CT) before treatment. The...
AIM To study the relationship between ABO blood groups and carcinoma of esophagus cardia in Chaoshan inhabitants China, which is a unique Littoral high-risk area esophageal China.The poor communication transportation past has made relatively closed kept its culture custure old China thousand years ago.METHODS Data on age, sex, type X-ray or patholog ical diagnose patients with were collected from Tumor Hospital.First
To evaluate the association between single nucleotide polymorphisms (SNPs) at 194 and 399 codons of XRCC1, risk severe acute skin oral mucosa reactions in nasopharyngeal carcinoma patients China.114 with were sequentially recruited this study. Heparinized peripheral blood samples taken for SNPs analysis before start radiation treatment. XRCC1 (194Arg/Trp 399Arg/Gln) gene analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Dermatitis upper neck mucositis...
Objective To compare plans using volumetric-modulated arc therapy (VMAT) with conventional sliding window intensity-modulated radiation (c-IMRT) to treat upper thoracic esophageal cancer (EC). Methods CT datasets of 11 patients EC were identified. Four generated for each patient: c-IMRT 5 fields (5F) and VMAT a single (1A), two arcs (2A), or three (3A). The prescribed doses 64 Gy/32 F the primary tumor (PTV64). dose-volume histogram data, number monitoring units (MUs) treatment time (TT)...
Abstract Purpose The purpose of this study is to investigate the dosimetric characteristics volumetric modulated arc therapy (VMAT) with flattening filter-free (FFF) beams and assess role VMAT in treatment advanced nasopharyngeal carcinoma (NPC). Methods Ten cases CT data were randomly selected from NPC patients. Three plans optimized for each patient, RapidArc FFF (RA-FFF), conventional (RA) static gantry intensity-modulated radiation (IMRT). doses planning target volumes (PTVs), organs at...
Abstract This study aimed to determine the optimal fraction scheme (FS) in patients with small peripheral non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy (SBRT) 4 × 12 Gy as reference. CT simulation data for sixteen diagnosed primary NSCLC or metastatic tumor a single lesion ≤3 cm were used this study. Volumetric modulated arc therapy (VMAT) plans designed based on ten different FS of 1 25 Gy, 30 34 3 15 18 20 5 6 10 and 7 Gy. Five radiobiological models employed...
It is important to determine the outcomes of retreatment in patients with locally recurrent nasopharyngeal carcinoma.We reviewed records treated for local recurrence at Stanford and Shantou Universities. The end points were relapse-free survival (LRFS) overall after retreatment.Fifty-six from 98 qualified. For patients, 33 had surgery alone (S group), 12 plus radiotherapy±chemotherapy (CMT 22 (RT group). All received 5-year LRFS rates were: 57% S group, 25% CMT 53% RT 41% group (P>0.05)...
Recent studies have shown association of mtDNA background with cancer development. We analyzed mitochondrial DNA (mtDNA) control region variation 201 patients nasopharyngeal carcinoma (NPC) and normal controls from Chaoshan Han Chinese to discern haplogroup effect on the disease onset. Binary logistic regression analysis adjustment for gender age revealed that R9 (P = 0.011, OR 1.91, 95% CI 1.16–3.16), particularly its sub-haplogroup F1 0.015, 2.43, 1.18–5.00), were associated significantly...
To study the dosimetric difference between fixed-jaw volumetric modulated radiotherapy (FJ-VMAT) and large-field (LF-VMAT) for nasopharyngeal carcinoma (NPC) with cervical lymph node metastasis.Computed tomography (CT) datasets of 10 NPC patients undergoing chemoradiotherapy were used to generate LF-VMAT FJ-VMAT plans in Eclipse version 10.0 treatment planning system. These two kinds then compared respect planning-target-volume (PTV) coverage, conformity index (CI), homogeneity (HI),...
Treatment responses of <TEX>$N_0$</TEX> stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes patients and identify prognostic factors. A total 610 with NPC, undergoing definitive radiotherapy their primary lesion prophylactic radiation upper neck, reviewed retrospectively. Concomitant chemotherapy was administrated 65 out the 610. Survival rates calculated using Kaplan-Meier method compared by log-rank test. Prognostic factors identified Cox...
A prognostic model should be established for distant metastasis in locally advanced nasopharyngeal carcinoma (NPC) after concurrent chemoradiotherapy (CCRT).Patients with NPC who received CCRT were divided into a construction set (230 patients) and validating (115 patients). The constructed index was derived on the former then tested latter.The score defined as number of adverse factors: age >45, N3 category, hemoglobin <11.0 g/dL lactate dehydrogenase ≥240 U/L. predicted 5-year...
AIM:To investigate clinical and pathologic data of esophageal carcinoma (EC) cardiac (CC) among residents in Chaoshan region China. METHODS:Clinical 9 650 patients with EC 4 173 CC the population were collected analyzed.Moreover, tissue arrays made for high-throughput study. RESULTS:Male to female ratio was 3:1 4.75:1 CC.The average age occurrence 54.6 years, 58.1 years.For both CC, at diagnosis a little younger than most other areas.The commonly affected site middle third esophagus (72.0%);...
Abstract Background This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes patients with oesophageal squamous cell carcinoma (OSCC) after definitive concurrent chemoradiotherapy (CCRT). Methods Altogether, 154 OSCC who underwent CCRT were included in this retrospective study. All randomised training cohort (n = 99) or validation 55). Pre-treatment CT scans obtained all and used extraction...
Aims and background It is known that arsenic trioxide (As 2 O 3 ) can induce clinical remission in patients suffering from acute promyelocytic leukemia. has been suggested the agent might also be effective against other malignancies. This study was done to explore efficacy of As treatment human nasopharyngeal cancer xenografts SCID (severe combined immunodeficiency) mice. Methods Human cells CSNE-1 cell line were implanted subcutaneously into mice produce tumors. The tumor inhibitory rate...
Derui, Li M.D.; Woo, D. V. Ph.D.; Emrich, J. M.S.; Steplewski, Z. Rodeck, U. Herlyn, D.V.M.; Koprowski, H. Miyamoto, C. Brady, L. W. M.D. Author Information
Aims and Background It was documented that nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) EBV-encoded latent membrane protein-1 expression (LMP1) plays an important role in the pathogenesis of NPC. In preclinical studies, arsenic trioxide (As 2 O 3 ) has been identified as a promising anticancer agent for treatment The purpose this study to investigate if can inhibit LMP1 therefore lead growth inhibition NPC cells vitro. Methods LMP1-positive cells, HNE1-LMP1,...
This study aimed to assess the predictive value of tumor volume changes esophagus evaluated by serial computed tomography (CT) scans before, during, and after radical chemoradiotherapy (CRT) for treatment outcomes in patients with esophageal cancer (EC).Fifty-three histologically confirmed EC were included analysis. Gross (GTVe) was manually contoured on CT images before treatment, at a twentieth fraction radiotherapy, completion CRT three months treatment. GTVe reduction ratio (RR)...
Purpose We aimed to evaluate the long-term outcomes of concurrent chemoradiotherapy (CCRT) with a simultaneous integrated boost (SIB) radiotherapy for esophageal squamous cell carcinoma (ESCC). Methods and Materials Eighty-seven patients primary ESCC enrolled in this phase II trial. The majority (92.0%) had locoregionally advanced disease. They underwent definitive chemoradiotherapy. doses were 66 Gy gross tumor 54 subclinical Doses simultaneously administered 30 fractions over 6 weeks. also...