We aimed to develop a combined predicting model for benign esophageal stenosis (BES) after simultaneous integrated boost (SIB) with concurrent chemotherapy in patients squamous cell carcinoma (ESCC). This study included 65 EC who underwent SIB chemotherapy. Esophageal was evaluated using esophagograms and the severity of eating disorders. Risk factors were investigated univariate multivariate analyses. Radiomics features extracted based on contrast-enhanced CT (CE-CT) before treatment. The...

C–N axially chiral compounds represent an important class of atropisomers that are prevalent in bioactive and material molecules. Despite recent advances synthetic methodologies, the asymmetric construction featuring multiple axes has been rarely explored, significantly limiting their further applications. Herein, we report a novel atroposelective synthesis diaxially pyridoindolones both six–five six–six through cobalt-catalyzed C–H annulation. This approach demonstrates exceptional...

Abstract Purpose: To ask whether the expression of immune markers and IFN signaling in tumor biopsies changes during concurrent chemoradiotherapy (CCRT). Experimental Design: Tumor peripheral mononuclear blood cells (PMBC) before immediately after 20 Gy/10 fractions (F) radiation treatment (RT) from 30 patients with cervical cancer receiving CCRT were evaluated by IHC qRT-PCR for correlated short-term response. Results: response to 10F RT as reflected CD8+ T-cell infiltration had substantial...

Purpose Stereotactic body radiotherapy (SBRT) is an important treatment modality for lung cancer patients, however, tumor local recurrence rate remains some challenge and there no reliable prediction tool. This study aims to develop a model of control patients undergoing SBRT based on radiomics signature combining with clinical dosimetric parameters. Methods The model, combined were developed by features, incorporating parameters signatures plus parameters, respectively. Three models...

Purpose Papillary thyroid cancer (PTC) has grown rapidly in prevalence over the past few decades, and central neck lymph node metastasis (CNLNM) is associated with poor prognoses. However, whether to carry out preventive dissection (CNLND) still controversial. We aimed construct a prediction model of CNLNM facilitate making clinical surgical regimens. Methods A total 691 patients PTC between November 2018 December 2021 were included our study. Univariate multivariate analyses performed on...

To investigate the value of radiomics models based on CT at different phases (non-contrast-enhanced and contrast-enhanced images) in predicting lymph node (LN) metastasis esophageal squamous cell carcinoma (ESCC).Two hundred seventy-four eligible patients with ESCC were divided into a training set (n =193) validation =81). The least absolute shrinkage selection operator algorithm (LASSO) was used to select features. predictive constructed features clinical factors through multivariate...

Cardio-cerebrovascular events are severe complications of diabetes.We aim to compare the incident risk cardio-cerebrovascular in maturity onset diabetes young (MODY), type 1 diabetes, and 2 diabetes.Type MODY were diagnosed by whole exome sequencing. The primary endpoint was occurrence first major adverse cardiovascular event (MACE), including acute myocardial infarction, heart failure, stroke, unstable angina pectoris, cardio-cerebrovascular-related mortality. Cox proportional hazards...

<b><i>Purpose:</i></b> Cardiotoxicity is an important side effect of anthracycline. Cardioprotective drugs for anthracycline remain inconclusive. We attempted to determine the role angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-receptor blockers (ARB) in prevention anthracycline-induced cardiotoxicity. <b><i>Hypothesis:</i></b> Prophylactic use ACEI/ARB reduces clinical or subclinical cardiotoxicity...

Abstract Background This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes patients with oesophageal squamous cell carcinoma (OSCC) after definitive concurrent chemoradiotherapy (CCRT). Methods Altogether, 154 OSCC who underwent CCRT were included in this retrospective study. All randomised training cohort (n = 99) or validation 55). Pre-treatment CT scans obtained all and used extraction...

Background For patients initially diagnosed with metastatic Her2-positive breast cancer (MHBC), we intended to construct a nomogram risk stratification predict prognosis and explore the role of local surgery. Methods We retrieved data from Surveillance, Epidemiology, End Results (SEER) database. Kaplan–Meier (KM) method log-rank test were used for selection significant variables. Cox regression analysis Fine-Gray utilized confirm independent prognostic factors overall survival (OS)...

Background and Aims. Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, clinicopathological value of circRNA for esophageal cancer (EC). Methods. screened relative studies from Pubmed, Embase, Web Science, Cochrane Library. The diagnostic role circRNAs was testified by pooled sensitivity specificity. Pooled odds ratio (OR) hazard (HR) were computed appraise prognostic value, respectively. Results....

Purpose We aimed to evaluate the long-term outcomes of concurrent chemoradiotherapy (CCRT) with a simultaneous integrated boost (SIB) radiotherapy for esophageal squamous cell carcinoma (ESCC). Methods and Materials Eighty-seven patients primary ESCC enrolled in this phase II trial. The majority (92.0%) had locoregionally advanced disease. They underwent definitive chemoradiotherapy. doses were 66 Gy gross tumor 54 subclinical Doses simultaneously administered 30 fractions over 6 weeks. also...

Background. We aimed to explore the prognosis of breast cancer patients with synchronous isolated distant-lymph node metastasis (SDLNM). Methods. extracted information from Surveillance, Epidemiology, and End Results Program. Kaplan-Meier Cox regression analyses were used compare overall survival (OS). Fine-Gray test was utilized cancer-specific (BCSS). applied propensity score matching (PSM) balance confounders. In total, 692 SDLNM allocated into training validation cohorts. Univariate...

Abstract Background: This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes patients with oesophageal squamous cell carcinoma (OSCC) after definitive concurrent chemoradiotherapy (CCRT). Methods: Altogether, 154 OSCC who underwent CCRT were included in this retrospective study. All randomised training cohort (n=99) or validation (n=55). Pre-treatment CT scans obtained all and used extraction...

Abstract Background: This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes oesophageal squamous cell carcinoma (OSCC) patients after definitive concurrent chemoradiotherapy (CCRT). Methods: Altogether, 154 with OSCC who underwent CCRT were included in this retrospective study. All separated randomly a training cohort (n=99) and validation (n=55). Pre-treatment CT scans obtained all used...

Abstract Background: This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes oesophageal squamous cell carcinoma (OSCC) patients after definitive concurrent chemoradiotherapy (CCRT). Methods: A total 151 ESCC who underwent CCRT were included in this retrospective study. All separated randomly a training cohort (n=97) and validation (n=54). Pre-treatment CT scans obtained all used extraction...

Abstract Background: This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for treatment outcomes patients with oesophageal squamous cell carcinoma (OSCC) after definitive concurrent chemoradiotherapy (CCRT). Methods: Altogether, 154 OSCC who underwent CCRT were included in this retrospective study. All randomised training cohort (n=99) or validation (n=55). Pre-treatment CT scans obtained all and used extraction...