A5102011091- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Genetic factors in colorectal cancer
- Retinal Development and Disorders
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
Shantou University
2006-2022
Cancer Hospital of Shantou University Medical College
2011-2022
National Yang Ming Chiao Tung University
2018
Taipei City Hospital
2018
Taipei Veterans General Hospital
2006
Shantou University Medical College
2006
Conjunctival biopsy is considered to be a simple, safe and specific diagnostic procedure for sarcoidosis. This study was designed determine the value of this in Taiwan.This conducted from December 2003 April 2005 at uveitis clinic Taipei Veterans General Hospital. Blind sampling conducted, obtaining sample measuring 1 cm long by 3 mm wide both lower fornices. A positive result defined as presence non-caseating granuloma when other granuloma-forming processes had been excluded.Twenty-nine...
Low doses of sodium iodate (NaIO3) impair visual function in experimental animals with selective damage to retinal pigment epithelium (RPE) and serve as a useful model study diseases caused by RPE degeneration. Mitochondrial dysfunction defective autophagy have been suggested play important roles normal aging well many neurodegenerative diseases. In this study, we examined whether NaIO3 treatment disrupted the mitochondrial-lysosomal axis cultured RPE.The human cell line, ARPE-19, was...
Adenosquamous carcinoma (ASC) of the lung is a relatively rare tumor with strong aggressiveness and poor prognosis. The analysis mutational signatures becoming routine in cancer genomics has implications for pathogenesis, classification, However, distribution ASC patients not been evaluated. In this study, we sought to reveal landscape genomic mutations ASC. Next-generation sequencing (NGS) technology was used retrieve information 124 patients. TP53 EGFR were most prevalent somatic observed,...
Aims and Background It was documented that nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) EBV-encoded latent membrane protein-1 expression (LMP1) plays an important role in the pathogenesis of NPC. In preclinical studies, arsenic trioxide (As 2 O 3 ) has been identified as a promising anticancer agent for treatment The purpose this study to investigate if can inhibit LMP1 therefore lead growth inhibition NPC cells vitro. Methods LMP1-positive cells, HNE1-LMP1,...
Poly ADP-Ribose Polymerase(PARP)plays an important role in the detection and repair of DNA damage.Inhibition PARP activity homologous-recombination defective cancer cell could lead to genomic instability ultimately cause death.In preclinical study inhibitors have demonstrated capacity enhancing sensitivity cancel cells chemotherapy agents radiation.PARP also showed antitumour potential early clinical trials as monotherapy or combined with chemotherapy. Key words:...
In recent years,mTOR inhibitors such as temsirolimus and everolimus are considered to be effective a new generation of anti-tumor agent.Their efficacies proven by number clinical trials especially in the field overcoming drug resistance tumor cells.But optimal combination regimen mTOR other drugs is still validated. Key words: Protein-serine-threonine kinases; Drug therapy; Neoplasms