About
Contact & Profiles
A5005551147
Research Areas
- Diet and metabolism studies
- Gut microbiota and health
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
Shanghai Jiao Tong University
2022-2025
XinHua Hospital
2022
Aberrant RNA splicing is tightly linked to diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we revealed that minor intron splicing, a unique and conserved processing event, largely disrupted upon the progression of steatohepatitis (MASH) in mice humans. We demonstrated deficiency induces MASH transition obesity-induced insulin resistance LXR activation. Mechanistically, inactivation leads retention Insig1 Insig2, resulting premature termination...
10.1172/jci186478
article
EN
cc-by
Journal of Clinical Investigation
2025-03-18
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