A5029882131- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Growth Hormone and Insulin-like Growth Factors
- Sleep and related disorders
- Breast Cancer Treatment Studies
École Polytechnique Fédérale de Lausanne
2022-2025
Estrogen and progesterone receptor (ER, PR) signaling control breast development impinge on carcinogenesis. ER is an established driver of + disease but the role PR, itself target gene, debated. We assess issue in clinically relevant settings by a genetic approach inject cancer cell lines patient-derived tumor cells to milk ducts immunocompromised mice. Such xenografts were exposed physiologically levels 17-β-estradiol (E2) (P4). find that independently both premenopausal E2 P4 increase...
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT can also occur secondary forms narcolepsy and be only temporary, suggesting it without irreversible neuronal loss. The recent discovery that patients show loss (corticotropin-releasing hormone) CRH-producing neurons suggests other mechanisms than cell-specific attack, are...
Abstract Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain stable, non-threatening, disease. Overtreatment thus presents pressing issue management. To understand the role normally tumour suppressive myoepithelial cell disease progression we present 3D vitro model incorporating both luminal and cells physiomimetic conditions. We demonstrate that DCIS-associated...
Abstract Background Pioneering research has shown that high-throughput epigenomics assays such as ChlP-seq and ATAC-seq are applicable to patient-derived breast tumor samples. A host of public data been accumulated since then, which potentially high value for basic well personalized medicine. Such sets constitute encyclopedias biological knowledge. However, their impact so far limited by access obstacles, especially with regard extraction visualization small portions could answer specific...