A5014785454- Characterization and Applications of Magnetic Nanoparticles
- Tryptophan and brain disorders
- Cardiac pacing and defibrillation studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Immune Cell Function and Interaction
- Lipoproteins and Cardiovascular Health
- Neurotransmitter Receptor Influence on Behavior
- Heart Rate Variability and Autonomic Control
- Nanoparticle-Based Drug Delivery
- Coronary Interventions and Diagnostics
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Peripheral Artery Disease Management
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Single-cell and spatial transcriptomics
- Dietary Effects on Health
- Cardiac electrophysiology and arrhythmias
- Cell Adhesion Molecules Research
- Iron oxide chemistry and applications
Icahn School of Medicine at Mount Sinai
2022-2024
Harvard University
2019-2024
Massachusetts General Hospital
2019-2024
Center for Systems Biology
2019-2023
Cardiovascular Institute of the South
2023
Charité - Universitätsmedizin Berlin
2011-2022
German Centre for Cardiovascular Research
2018-2022
Humboldt-Universität zu Berlin
2018-2022
Freie Universität Berlin
2018-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
Introduction Atherosclerosis is the underlying cause of multiple cardiovascular pathologies. The present-day clinical imaging modalities do not offer sufficient information on plaque composition or rupture risk. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) a strongly upregulated proteoglycan-cleaving enzyme that specific to diseases, inter alia, atherosclerosis. Materials Methods Male apolipoprotein E-deficient mice received high-fat diet for 2 (n = 11) months...
A sleepless night may feel awful in its aftermath, but sleep's revitalizing powers are substantial, perpetuating the idea that convalescent sleep is a consequence-free physiological reset. Although recent studies have shown catch-up insufficiently neutralizes negative effects of debt, mechanisms control prolonged disruption not understood. Here, we show interruption restructures epigenome hematopoietic stem and progenitor cells (HSPCs) increases their proliferation, thus reducing clonal...
In vivo tracking of nanoparticle-labeled cells by magnetic resonance imaging (MRI) crucially depends on accurate determination cell-labeling efficacy prior to transplantation. Here, we analyzed the feasibility and accuracy particle spectroscopy (MPS) for estimation in living THP-1 incubated with very small superparamagnetic iron oxide nanoparticles (VSOP). Cell viability proliferation capacity were not affected MPS measurement procedure. VSOP samples without cell contact, enabled highly...
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive a checkpoint leukocyte compartment sizes. Here, we examined impact reversible inhibition this by small-molecule A485. We found that A485 triggered acute and transient mobilization leukocytes from bone marrow into blood. Leukocyte was equally potent as, but mechanistically distinct from, granulocyte colony-stimulating factor (G-CSF), which allowed for additive...
The transcatheter aortic valve SAPIEN 3 aims at reducing paravalvular leakage (PVL). new design with outer sealing cuff may increase the risk of permanent pacemaker implantation (PPM). aim our study was to evaluate optimal height 3.We analysed correlation between and need for PPM in 131 patients. rate entire group after TAVI 18% (n = 24). In patients a marker distance <2 mm ("low implantation"), 32%, whereas ≥2 ("high only 4.7% (OR 0.1 (0.03-0.37, P < 0.001)).The periprocedural Edwards...
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)—a class of nuclear and transcription factors with diverse functions in metabolism immunity—critically contribute to thymic integrity function. LXRαβ-deficient mice develop fatty, rapidly involuting acquire shrunken prematurely immunoinhibitory peripheral repertoire. LXRαβ’s are specific, the resulting phenotypes mutually independent. Although macrophages require LXRαβ...
Abstract That activation of the reward system involves increased activity dopaminergic (DA) neurons in ventral tegmental area (VTA) is widely accepted. In contrast, lateral habenular complex (LHb), which known as center anti‐reward system, directly and indirectly inhibits DA VTA. The VTA, however, not a homogenous entity. Instead, it displays major functional differences between its anterior (aVTA) posterior (pVTA) regions. It precisely known, whether input to aVTA, pVTA, newly recognized...
Abstract Very small superparamagnetic iron oxide nanoparticles (VSOPs) rapidly accumulate in atherosclerotic lesions, thereby enabling plaque visualization by magnetic resonance imaging (MRI). This study was performed to identify the uptake mechanisms of VSOPs into plaques. Low-density lipoprotein receptor-deficient (LDLR −/− ) mice with advanced atherosclerosis were analyzed using MRI and transmission electron microscopy (TEM) at various time points after intravenous administration VSOPs....
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned nuclear transcripts, data on biological of small cytosolic are sparse. We previously found NEAT1−/− and MALAT1−/− mice display massive atherosclerosis vascular inflammation. Here, employing selective targeted disruption menRNA or mascRNA, we...