A5041086338- Advanced Glycation End Products research
- Heart Rate Variability and Autonomic Control
- COVID-19 and Mental Health
- Cardiac Structural Anomalies and Repair
- Natural Antidiabetic Agents Studies
- Non-Invasive Vital Sign Monitoring
- Resilience and Mental Health
- Infective Endocarditis Diagnosis and Management
- COVID-19 epidemiological studies
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Gout, Hyperuricemia, Uric Acid
- Biochemical effects in animals
- Advanced MRI Techniques and Applications
- Healthcare professionals’ stress and burnout
- COVID-19 diagnosis using AI
- Cardiovascular and exercise physiology
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Cardiac Imaging and Diagnostics
- Fatty Acid Research and Health
- Anomaly Detection Techniques and Applications
- Biomedical Research and Pathophysiology
- Optimism, Hope, and Well-being
- Radiomics and Machine Learning in Medical Imaging
Icahn School of Medicine at Mount Sinai
2013-2025
New York Proton Center
2024
Mount Sinai Hospital
2023
Diabetes Australia
2010
Tallahassee Orthopedic Clinic
2010
OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important in the development persistence of insulin resistance (IR). Several anti-inflammatory cell-protective mechanisms, including advanced glycation end product (AGE) receptor-1 (AGER1) sirtuin (silent mating-type information regulation 2 homolog) 1 (SIRT1) suppressed diabetes. Because basal OS type diabetic patients is influenced by consumption AGEs, we examined whether AGE also affects IR AGER1 SIRT1 involved....
Changes in autonomic nervous system function, characterized by heart rate variability (HRV), have been associated with infection and observed prior to its clinical identification. We performed an evaluation of HRV collected a wearable device identify predict COVID-19 related symptoms. Health care workers the Mount Sinai System were prospectively followed ongoing observational study using custom Warrior Watch Study app, which was downloaded their smartphones. Participants wore Apple for...
Context: Increased oxidant stress and inflammation (OS/infl) are linked to both aging-related diseases advanced glycation end products (AGEs). Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed normal humans. Objective: The objectives of the study were determine whether AGER1 correlates with AGEs a reduction dietary (dAGEs) lowers healthy adults chronic kidney disease (CKD-3) patients. Design: This was cross-sectional 2-yr follow-up studies CKD-3 patients,...
Increased inflammation and oxidative stress may be caused by proteins lipids modified cytotoxic advanced glycation end products (AGEs) in food. Restricting food containing elevated AGEs improves these risk factors diabetic CKD. Because diet adherence can problematic, this study aimed to remove from already ingested determine whether sevelamer carbonate sequesters the gut, preventing their uptake thereby reducing AGE-induced abnormalities.
Although obesity can predispose to the metabolic syndrome (MS), diabetes, and cardiovascular disease, not all obese subjects develop MS, hence need for new indicators of risk this syndrome. Advanced glycation end products (AGEs) correlate with factors involved in including inflammation insulin resistance (IR). Because AGEs be derived from food are modifiable, it is important determine whether they a factor MS.The objective study was assess association endogenous exogenous MS criteria.The...
Myocardial replacement fibrosis has been reported to occur in one-third of patients with mitral valve prolapse (MVP) and significant regurgitation (MR). However, it remains unknown whether there are detectable changes myocardial metabolism suggestive inflammation or ischemia that accompany the development fibrosis.To characterize burden distribution fluorine 18-labeled (18F) fluorodeoxyglucose (FDG) uptake late gadolinium enhancement (LGE) degenerative MVP ventricular ectopy.Prospective...
Gout, caused by hyperuricemia and subsequent deposition of aggregated monosodium urate crystals (MSU) in the joints or extra-articular regions, is most common inflammatory arthritis. There increasing evidence that gout an independent risk factor for hypertension, cardiovascular disease progression mortality.To evaluate if dual energy computed tomography (DECT) could identify MSU within vessel walls patients, deposits vasculature differed between patients with controls. This study may help...
Background Heart rate variability (HRV) biofeedback is often performed with structured education, laboratory-based assessments, and practice sessions. It has been shown to improve psychological physiological function across populations. However, a means remotely use monitor this approach would allow for wider of technique. Advancements in wearable digital technology present an opportunity the widespread application approach. Objective The primary aim study was determine feasibility fully...
Abstract Objective To determine whether a machine learning model can detect SARS-CoV-2 infection from physiological metrics collected wearable devices. Materials and Methods Health care workers 7 hospitals were enrolled prospectively followed in multicenter observational study. Subjects downloaded custom smart phone app wore Apple Watches for the duration of study period. Daily surveys related to symptoms diagnosis Coronavirus Disease 2019 answered app. Results We 407 participants with 49...
The COVID-19 pandemic has resulted in a high degree of psychological distress among health care workers (HCWs). There is need to characterize which HCWs are at an increased risk developing effects from the pandemic. Given differences response individuals stress, analysis both perceived and physiological consequences stressors can provide comprehensive evaluation its impact.This study aimed determine characteristics associated with longitudinal stress assess whether changes heart rate...
Abstract Objective To assess whether an individual’s degree of psychological resilience can be determined from physiological metrics passively collected a wearable device. Materials and Methods Data were analyzed in this secondary analysis the Warrior Watch Study dataset, prospective cohort healthcare workers enrolled across 7 hospitals New York City. Subjects wore Apple for duration their participation. Surveys measuring resilience, optimism, emotional support at baseline. Results We...
We assessed changes in vascular inflammation and monosodium urate (MSU)-coded deposits after administration of Pegloticase the vasculature tophaceous gout patients using 18F-fluorodeoxyglucose (18F-FDG) Positron emission tomography/computed tomography (PET/CT) dual-energy CT (DECT). Ten with gout, intolerant or refractory to urate-lowering therapy (ULT), were treated every two weeks for six months. 18F-FDG PET/CT DECT performed at baseline detect vessel wall (Standard uptake value, SUVmean,...
ABSTRACT Background Changes in autonomic nervous system function, characterized by heart rate variability (HRV), have been associated with and observed prior to the clinical identification of infection. We performed an evaluation this metric collected wearable devices, identify predict Coronavirus disease 2019 (COVID-19) its related symptoms. Methods Health care workers Mount Sinai System were prospectively followed ongoing observational study using custom Warrior Watch Study App which was...