A5041828737- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Analytical chemistry methods development
- Machine Learning in Bioinformatics
- Advanced MRI Techniques and Applications
- Heavy metals in environment
- Lanthanide and Transition Metal Complexes
- Receptor Mechanisms and Signaling
- Protease and Inhibitor Mechanisms
- Prostate Cancer Treatment and Research
- Mercury impact and mitigation studies
- Medical Imaging Techniques and Applications
- Cardiovascular Disease and Adiposity
Anna Needs Neuroblastoma Answers
2023
Maine Farmland Trust
2023
University of Münster
2021-2022
Introduction Atherosclerosis is the underlying cause of multiple cardiovascular pathologies. The present-day clinical imaging modalities do not offer sufficient information on plaque composition or rupture risk. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) a strongly upregulated proteoglycan-cleaving enzyme that specific to diseases, inter alia, atherosclerosis. Materials Methods Male apolipoprotein E-deficient mice received high-fat diet for 2 (n = 11) months...
Constant interactions between tumor cells and the extracellular matrix (ECM) influence progression of prostate cancer (PCa). One key components ECM are collagen fibers, since they responsible for tissue stiffness, growth, adhesion, proliferation, migration, invasion/metastasis, cell signaling, immune recruitment cells. To explore this molecular marker in content PCa, we investigated two different volumes (500 mm3 1000 mm3) a xenograft mouse model PCa with magnetic resonance imaging (MRI)...
Abstract In a dual approach, laser ablation-inductively coupled plasma-mass spectrometry was applied to investigate spleen samples of rats after intratracheal instillation polyvinylpyrrolidone-coated gold nanoparticles. First, spatially resolved imaging analysis deployed translocation from the lungs and distribution pattern in parenchyma itself. Using same instrumental setup, single particle mode determine species translocated gold. Single allows determination size distributions therefore...
Background Gadolinium-based contrast agents (GBCAs) are applied to enhance magnetic resonance imaging. Gadolinium (Gd), a rare earth metal, is used in chelated form when administered as GBCA patients. There an ongoing scientific debate about the clinical significance of Gd retention tissues after administration GBCAs. It known that bone serves reservoir, but only sparse information on localization available. Purpose The aim this study was compare tissue concentration and spatial distribution...
Motivation: A precise diagnosis of atherosclerosis is clinical importance, since cardiovascular disease remain one the leading causes death worldwide. Goal(s): The goal this study was to evaluate feasibility characterizing a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS4) using molecular magnetic resonance imaging in preclnical model atherosclerosis. Approach: Molecular novel probe targeted against ADAMTS4 used high-fat murine model. Results: It possible image...