A5004035127- Bone health and treatments
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Lipoproteins and Cardiovascular Health
- Wnt/β-catenin signaling in development and cancer
- NF-κB Signaling Pathways
- Radiopharmaceutical Chemistry and Applications
- Biomarkers in Disease Mechanisms
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Treatment and Research
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Ovarian cancer diagnosis and treatment
- Pharmacogenetics and Drug Metabolism
- Methodologies in Health Research and Practice
- TGF-β signaling in diseases
- Clusterin in disease pathology
Technische Universität Dresden
2014-2024
German Cancer Research Center
2018-2024
Heidelberg University
2018-2024
University Hospital Carl Gustav Carus
2020-2022
Helmholtz-Zentrum Dresden-Rossendorf
2021-2022
National Center for Tumor Diseases
2021-2022
St. Antonius Ziekenhuis
2016
University Hospital Schleswig-Holstein
2013
University of Lübeck
2013
Abstract The mevalonate pathway has emerged as a promising target for several solid tumors. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), rate-limiting enzyme this pathway, and commonly used to treat patients with hypercholesterolemia. Pleiotropic antitumor mechanisms statins have been demonstrated human cancer types. However, cells differ in their individual statin sensitivity some cell lines shown relative resistance. In study we demonstrate, that breast...
The Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition, there is increasing data suggest direct tumor promoting effects DKK-1. prognostic role DKK-1 expression in prostate cancer remains unclear. A tissue microarray (n = 400) was stained for and serum levels were measured 80 patients with cancer. independent value assessed using multivariate analyses. significantly increased compared benign disease, but...
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive a checkpoint leukocyte compartment sizes. Here, we examined impact reversible inhibition this by small-molecule A485. We found that A485 triggered acute and transient mobilization leukocytes from bone marrow into blood. Leukocyte was equally potent as, but mechanistically distinct from, granulocyte colony-stimulating factor (G-CSF), which allowed for additive...
Abstract The Wnt inhibitor Dickkopf-1 (DKK-1) has been associated with the occurrence of bone metastases in osteotropic prostate cancer by inhibiting osteoblastogenesis. P38 mitogen-activated protein kinase (MAPK) activity is also dysregulated advanced cancer. However, impact p38 MAPK signaling on DKK-1 remains unknown. Inhibition osteolytic PC3 cells small molecule inhibitors (doramapimod, LY2228820 and SB202190) suppressed expression, whereas activation anisomycin increased DKK-1. Further...
ABSTRACT Prostate cancer is the most frequent malignancy in men, and a major cause of prostate cancer–related death attributable to bone metastases. WNT5A known influence clinical outcome various types, including cancer, but exact mechanisms remain unknown. The goal this study was assess relevance for development progression cancer. expression determined cDNA tissue microarray primary tumor samples well-defined cohorts patients with Compared benign tissue, its receptor Frizzled-5 higher...
Abstract Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in majority of cases, metastatic spread peritoneal cavity and onset chemo-resistance. Thus, novel approaches required. Statins amino-bisphosphonates inhibitors mevalonate pathway, which is a fundamental pathway cellular metabolism, essential for cholesterol production posttranslational protein farnesylation geranylgeranylation. While this has...
We assessed serum concentrations of the receptor activator NFκB ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG), two proteins implicated in development progression breast cancer, 509 patients with primary, nonmetastatic cancer. Then results were evaluated regards to occurrence bone metastases, presence disseminated tumor cells (DTC) marrow, survival, risk developing metastatic disease.Before surgery, marrow aspirates analyzed for DTC using density centrifugation followed by...
Dominant and territorial behaviour are known social phenomena in cichlids stress influences reproduction growth. The gonadotropic hormones trigger spermatogenesis subordinate males have typically lower levels of gonadotropins than dominant males. In this study, we compared testis morphology gene expression Nile tilapia (d- s-males) socially stable communities. d-males had the highest gonadosomatic index but they were not largest animals majority studied cases. Long-term showed large groups...
Abstract Introduction Amino-bisphosphonates and statins inhibit the mevalonate pathway, may exert anti-tumor effects. The Wnt inhibitor dickkopf-1 (DKK-1) promotes osteolytic bone lesions by inhibiting osteoblast functions has been implicated as an adverse marker in multiple cancers. We assessed effects of pathway inhibition on DKK-1 expression osteotropic breast cancer. Methods Regulation bisphosphonates was human cancer cell lines, role downstream targets analyzed. Moreover, potential...
// Stefanie Thiele 1, 2 , Ariane Zimmer Andy Göbel Tilman D. Rachner Sandra Rother 3 Susanne Fuessel 4 Michael Froehner Manfred P. Wirth H. Muders 5 Gustavo B. Baretton Franz Jakob 6 Martina Rauner and Lorenz C. Hofbauer 2, 7 1 Division of Endocrinology Metabolic Bone Diseases, Department Medicine III, Dresden, Germany Center for Healthy Aging, Technische Universität Dresden Medical Center, Institute Materials Science, Max Bergmann Biomaterials, Urology, Pathology, Orthopedic Musculoskeletal...
The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on metabolism, but the mode action biology remains unclear. In this study, we assessed potential bone-protective context osteotropic tumors.The cancer cell viability vitro and tumor growth vivo were assessed. Everolimus-regulated osteoclastogenesis osteoblastogenesis also before effect a...
Abstract Background Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted that mainly produced in the liver. Elevated levels of LRG-1 are found multitude pathological conditions including eye diseases, diabetes, infections, autoimmune and cancer. In patients with early breast cancer (BC), high intratumoral protein expression associated reduced survival. this study, we assessed serum BC investigated its correlation presence disseminated tumor cells (DTCs) bone marrow survival outcomes....
Prostate cancer is the most prevalent malignancy in men. While diagn ostic and therapeutic interventions have substantially improved recent years, disease relapse, treatment resistance, metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel approaches are needed. Statins inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), rate-limiting enzyme mevalonate pathway which plays an essential role cholesterol homeostasis. Numerous preclinical...
Abstract Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that physiological and pathological Dickkopf1 (DKK1) activity fuels cytokine responses in cell models, mice humans. DKK1 maintains elevated tone of cancer cells is required for mounting following ligation toll-like receptors. DKK1-controlled inflammation derives from cell-autonomous mechanisms, which involve SOCS3-restricted, nuclear RelA...
Breast cancer is a heterogeneous disease and the mechanistic framework for differential osteotropism among intrinsic breast subtypes unknown. Hypothesizing that cell morphology could be an integrated readout functional state of cell, we established catalogue migratory, molecular biophysical traits MDA-MB-231 cells, compared it with two enhanced bone-seeking derivative lines these findings single profiles. Such knowledge essential predicting metastatic capacities in cancer. High-resolution...