A5048798101- Iron Metabolism and Disorders
- Trace Elements in Health
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Systemic Lupus Erythematosus Research
- Growth Hormone and Insulin-like Growth Factors
- Hemoglobinopathies and Related Disorders
- Rheumatoid Arthritis Research and Therapies
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Birth, Development, and Health
- Axon Guidance and Neuronal Signaling
- Pregnancy and preeclampsia studies
- Retinal and Optic Conditions
- Nuclear Receptors and Signaling
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
University Hospital Carl Gustav Carus
2024-2025
Technische Universität Dresden
2020-2024
Universidad Nacional Autónoma de México
2013-2023
Autonomous University of Queretaro
2018-2020
Chondrocytes are the only cells in cartilage, and their death by apoptosis contributes to cartilage loss inflammatory joint diseases, such as rheumatoid arthritis (RA). A putative therapeutic intervention for RA is inhibition of apoptosis-mediated degradation. The hormone prolactin (PRL) frequently increases circulation patients with RA, but role hyperprolactinemia disease activity unclear. Here, we demonstrate that PRL inhibits cultured chondrocytes response a mixture proinflammatory...
Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical regulator of systemic levels. Loss Tfr2 function humans and mice results overload. As contributes to processes, we investigated whether Tfr2-deletion affects the pathogenesis iron-dependent manner.Using global conditional genetic disruption Tfr2, assessed relevance K/BxN serum-transfer (STA) macrophage polarization.Male Tfr2-/-...
Abstract Transferrin receptor 1 (Tfr1) plays a key role in mediating the cellular uptake of transferrin-bound iron. While Tfr1 is essential for iron erythroid cells and skeletal muscle, it dispensable acquisition hepatocytes, intestinal epithelial, or endothelial cells. In this study, we investigated significance function bone-forming osteoblasts. Therefore, examined bone characteristics male female Tfr1fl/fl;Osx:cre+/−(osteoprogenitors) conditional knockout mice at 12 24 wk age. Bone...
Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against loss AIA monoarticular (MAIA). Joint trabecular loss, osteoclastogenesis were evaluated treated (via osmotic minipumps) mice MAIA that null (Prlr-/-) or not (Prlr+/+) for receptor. To help define target cells, synovial fibroblasts from Prlr+/+ proinflammatory cytokines ((Cyt), including...
Abstract Periodontitis is associated with significant alveolar bone loss. Patients iron overload suffer more frequently from periodontitis, however, the underlying mechanisms remain largely elusive. Here, we investigated role of transferrin receptor 2 (Tfr2), one main regulators homeostasis, in pathogenesis periodontitis and dental phenotype under basal conditions mice. As Tfr2 suppresses osteoclastogenesis, hypothesized that deficiency may exacerbate periodontitis‐induced Mice lacking ( −/−...
Myelodysplastic syndromes (MDS) are clonal malignant hematopoietic disorders in the elderly characterized by ineffective hematopoiesis. This is accompanied an altered bone microenvironment, which contributes to MDS progression and higher fragility. The underlying mechanisms remain largely unexplored. Here, we show that myelodysplastic NUP98‑HOXD13 (NHD13) transgenic mice display abnormally high number of osteoblasts, yet a fraction nonmineralized bone, indicating delayed mineralization. was...
Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent hypervasopermeability associated with diabetes. Enhanced bradykinin (BK) production contributes increased transport through blood-retina barrier (BRB) Here, we studied if vasoinhibins regulate BRB permeability by targeting vascular endothelium and retinal pigment epithelium (RPE) components of this barrier. Intravitreal injection BK male rats permeability. prevented effect, as did B2 receptor...
The liver grows during the early postnatal period first at slower and then faster rates than body to achieve adult liver-to-body weight ratio (LBW), a constant reflecting health. hormone prolactin (PRL) stimulates growth regeneration, its levels are high in circulation of newborn infants, but whether PRL plays role neonatal is unknown. Here, we show that produces upregulates receptor mice 2 wk after birth, when lags behind growth. At week 4, production by ceases coinciding with elevation...
The levels of the hormone prolactin (PRL) are reduced in circulation patients with Type 2 diabetes and obese children, lower systemic PRL correlate an increased prevalence a higher risk metabolic syndrome. secretion anterior pituitary (AP) diseases may be influenced by interplay between transforming growth factor β (TGF-β) tumor necrosis α (TNF-α), which inhibit can stimulate AP synthesis, respectively, known contributors to insulin resistance complications. Here, we show that TGF-β TNF-α...
Ferroportin (FPN) is the only known iron exporter. Mutations conferring resistance of FPN to hepcidin-mediated degradation cause overload disorder hereditary hemochromatosis type 4. While associated with low bone mass, mechanisms involved are not completely understood. Here, we aimed investigate whether disruption in hepcidin/FPN axis FpnC326S mice and subsequent systemic accumulation impacts on tissue a similar extent as Hfe−/− mice, which hallmarked by milder phenotype. show increased...
Abstract Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that physiological and pathological Dickkopf1 (DKK1) activity fuels cytokine responses in cell models, mice humans. DKK1 maintains elevated tone of cancer cells is required for mounting following ligation toll-like receptors. DKK1-controlled inflammation derives from cell-autonomous mechanisms, which involve SOCS3-restricted, nuclear RelA...
Inflammatory arthritis defines a family of diseases influenced by reproductive hormones. Vasoinhibin, fragment the hormone prolactin (PRL), has antiangiogenic and proinflammatory properties. We recently showed that vasoinhibin reduces joint inflammation bone loss in severe antigen-induced (AIA) an indirect mechanism involving inhibition pannus vascularization. This unexpected finding led us to hypothesize level AIA obscured direct action while allowing anti-inflammatory effect via its In...
The close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL both proinflammatory anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that modifies an opposite manner the actions of IL-1β TNF-α mouse synovial fibroblasts culture. Both upregulated metabolic activity expression factors (Il1b, Inos, Il6) via activation nuclear factor-κB (NF-κB) signaling...
<b><i>Background:</i></b> Vasoinhibin, a protein derived from prolactin, regulates various vascular functions including endothelial cell survival. Of note, vasoinhibin is present in the central nervous system, where it triggers neuroendocrine and behavioral responses to stress. Moreover, compromises nerve growth factor (NGF)-induced neurite outgrowth primary sensory neurons of peripheral system. Nonetheless, information on developing remains limited. The study...
Bone is susceptible to fluctuations in iron homeostasis, as both deficiency and overload are linked poor bone strength humans. In mice, however, inconsistent results have been reported, likely due different diet setups or genetic backgrounds. Here, we assessed the effect of high low diets on six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H/HeJ, DBA/2J). Mice received a (20,000 ppm) low-iron (~10 after weaning for 6–8 weeks. For C57BL/6J males, used two dietary with similar...
Iron is an essential nutrient for all living organisms. Both iron deficiency and excess can be harmful. Bone, a highly metabolic active organ, particularly sensitive to fluctuations in levels. In this study, we investigated the effects of dietary overload on bone homeostasis with specific focus two frequently utilized mouse strains: 129/Sv C57BL/6J. Our findings revealed that after 6 weeks iron-rich diet, mice exhibited decrease trabecular cortical density both vertebral femoral bones, which...