A5054657847- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Connective tissue disorders research
- Bone and Dental Protein Studies
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Vitamin K Research Studies
- Medical Imaging and Pathology Studies
- Bone Tissue Engineering Materials
- Alkaline Phosphatase Research Studies
- Hip and Femur Fractures
- Dermatological and Skeletal Disorders
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- Vitamin C and Antioxidants Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thyroid and Parathyroid Surgery
- Wnt/β-catenin signaling in development and cancer
- Erythrocyte Function and Pathophysiology
- Radiopharmaceutical Chemistry and Applications
- Neurogenetic and Muscular Disorders Research
- Pharmacological Effects and Toxicity Studies
Hanusch Hospital
2015-2024
Ludwig Boltzmann Institute of Osteology
2015-2024
Ludwig Boltzmann Institute for Digital Health and Prevention
2020-2023
Erich Schmid Institute of Materials Science
2003
Austrian Academy of Sciences
2003
Montanuniversität Leoben
2003
Anabolic effects of PTH have been observed at several skeletal sites in humans by dual x-ray absorptiometry without differentiating between an actual increase bone volume and mineral content within already established bone. The present study addressed this issue evaluating the mineralization density distribution iliac crest biopsies before after treatment for 18–36 months men women with osteoporosis using quantitative backscattered electron imaging. In cortical bone, pairwise comparison two...
Abstract Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to as a cofactor for collagen maturation. Here, we demonstrate that epigenetically orchestrates osteogenic differentiation and by modulating chromatin accessibility priming transcriptional activity. regulates histone demethylation (H3K9me3 H3K27me3) promotes TET-mediated 5hmC DNA hydroxymethylation at promoters, enhancers super-enhancers near...
Strontium ranelate (SrR) is a relatively new treatment for osteoporosis. In this study we investigated its potential impact on human bone material quality in transiliac biopsies from postmenopausal osteoporotic women treated 3 years with calcium and vitamin D plus either 2 g SrR per day or placebo. Bone mineralization density distribution (BMDD), strontium (Sr) concentration, collagen cross-link ratio, indentation modulus were analyzed by quantitative backscattered electron imaging,...
Long-term treatment studies showed that the therapeutic effects of alendronate (ALN) were sustained over a 10-year period. However, data on intrinsic bone material properties by long-term reduction turnover are still sparse. We analyzed transiliacal biopsies subgroup 30 Fracture Intervention Trial Long-Term Extension (FLEX) participants (n = 6 treated for 10 years with ALN at dose mg/day, n 5 and 14 plus further placebo) quantitative backscattered electron imaging (qBEI) scanning small-angle...
Abstract Idiopathic osteoporosis (IOP) in premenopausal women is characterized by fragility fractures at low or normal bone mineral density (BMD) otherwise healthy with gonadal function. Histomorphometric analysis of transiliac biopsy samples has revealed microarchitectural deterioration cancellous and thinner cortices. To examine material quality, we measured the mineralization distribution (BMDD) quantitative backscattered electron imaging (qBEI), mineral/matrix ratio,...
Osteoporotic fragility fractures were hypothesized to be related changes in bone material properties and not solely reduction mass. We studied cortical from the superior inferior sectors of whole femoral neck sections five female osteoporotic hip fracture cases (74–92 years) nonfractured controls (75–88 years). The typical calcium content (CaPeak) mineral particle thickness parameter (T) mapped large areas regions using quantitative backscattered electron imaging (qBEI) scanning small-angle...
ABSTRACT The Skeletal Histomorphometry in Patients on Teriparatide or Zoledronic Acid Therapy (SHOTZ) study assessed the progressive effects of teriparatide (TPTD) and zoledronic acid (ZOL) bone remodeling material properties postmenopausal women with osteoporosis. Previously, we reported that biochemical histomorphometric formation indices were significantly higher patients receiving TPTD versus ZOL. Here report mineralization density distribution (BMDD) results based quantitative...
Abstract Anabolic treatment with teriparatide of postmenopausal osteoporotic patients previously treated bisphosphonates is a new therapeutic approach. However, its effects on the bone mineralization density distribution (BMDD) are unknown. We studied paired transiliac biopsy samples taken before and after 1 year recombinant human parathyroid hormone peptide 1-34 (teriparatide) from 16 women either alendronate (priorALN) or risedronate (priorRIS) for at least 2 years subsequently 12 months...
Duchenne muscular dystrophy (DMD) is a genetic disorder causing progressive muscle weakness. To prolong independent ambulation, DMD patients are treated with glucocorticoids, which, in turn, can increase bone fragility. In cohort vertebral fractures, intravenous bisphosphonate (iv BP) therapy stabilized vertebrae and reduced back pain. characterize the effects of glucocorticoid treatment on tissue material properties, paired transiliac biopsy samples (before after average 2.4 years iv from 9...
ABSTRACT Disuse of the musculoskeletal system causes bone loss. Whether patients in vegetative state, a dramatic example immobilization after severe brain injury, suffer from loss and fractures is currently unknown. Serum markers turnover, mineral density (BMD) measurements, clinical data were cross-sectionally analyzed 30 consecutive state dedicated apallic care unit between 2003 2007 compared with age- sex-matched healthy individuals. Vegetative showed low calcium levels vitamin D...
Significance Statement Renal osteodystrophy (ROD) contributes substantially to morbidity in CKD, including increased fracture risk. Metabolic acidosis (MA) the development of ROD, but an up-to-date skeletal phenotype CKD-associated has not been described. We comprehensively studied associations between and bone patients with CKD using advanced methods image skeleton analyze bone-tissue, along biochemical testing. Cross-sectionally, was associated higher markers remodeling female-specific...
ABSTRACT The spectrum of therapeutic options and the amount clinical trials for male osteoporosis (mOP) is lower than those postmenopausal osteoporosis. Therefore, we examined effects 24 months ibandronate (IBN) treatment (3 mg/3 mL intravenously every 3 months) on bone material quality in 19 subjects with mOP within an open-label, single-center, prospective phase III study (Eudract number 2006-006692-20). Patients (median age [25th, 75th percentiles] 53.0 [44.5; 57.0] years) were included...
Patients with hypoparathyroidism have low circulating parathyroid (PTH) levels and higher cancellous bone volume trabecular thickness. Treatment PTH(1-84) was shown to increase abnormally remodeling dynamics. In this work, we studied the effect of 1-year or 2-year treatment on cortical mineralization density distribution (Cn.BMDD Ct.BMDD) based quantitative backscattered electron imaging (qBEI) in paired transiliac biopsy samples. The study cohort comprised 30 adult hypoparathyroid patients...
Abstract Quantitative backscattered electron imaging is an established method to map mineral content distributions in bone and determine the mineralization density distribution (BMDD). The we applied was initially validated for a scanning microscope (SEM) equipped with tungsten hairpin cathode (thermionic emission) under strongly defined settings of SEM parameters. For several reasons, it would be interesting migrate technique field emission source (FE-SEM), which, however, require work...