A5023655083- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Medical Imaging and Pathology Studies
- Bone health and osteoporosis research
- Bone health and treatments
- Renal function and acid-base balance
- Bone Metabolism and Diseases
- Metabolism and Genetic Disorders
Columbia University
2025
Columbia University Irving Medical Center
2020-2023
Secondary hyperparathyroidism is associated with osteoporosis and fractures. Etelcalcetide an intravenous calcimimetic for the control of in patients on hemodialysis. Effects etelcalcetide skeleton are unknown.
Significance Statement Renal osteodystrophy (ROD) contributes substantially to morbidity in CKD, including increased fracture risk. Metabolic acidosis (MA) the development of ROD, but an up-to-date skeletal phenotype CKD-associated has not been described. We comprehensively studied associations between and bone patients with CKD using advanced methods image skeleton analyze bone-tissue, along biochemical testing. Cross-sectionally, was associated higher markers remodeling female-specific...
Abstract BACKGROUND A significant number of kidney transplant recipients have low BMD. We hypothesized that calcitriol administration over the first year post-transplantation would protect cortical skeleton in managed without corticosteroids by suppressing PTH and bone remodeling. METHODS In this double-blind, placebo-controlled trial, 67 participants aged ≥18 years on corticosteroid-sparing immunosuppressive regimen were randomized to daily 0.5 mcg or placebo for 12 months after...
ABSTRACT A main obstacle to diagnose and manage renal osteodystrophy (ROD) is the identification of intracortical bone turnover type (low, normal, high). The gold standard, tetracycline‐labeled transiliac crest biopsy, impractical obtain in most patients. Kidney Disease Improving Global Outcomes Guidelines recommend PTH bone‐specific alkaline phosphatase (BSAP) for diagnosis type. However, BSAP have insufficient diagnostic accuracy differentiate low from non‐low were validated trabecular...