A5031877252- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Pregnancy and preeclampsia studies
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Retinal and Macular Surgery
- Metabolism, Diabetes, and Cancer
- Renin-Angiotensin System Studies
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Neurological Complications and Syndromes
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Intracranial Aneurysms: Treatment and Complications
- Vagus Nerve Stimulation Research
- Regulation of Appetite and Obesity
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
Universidad Nacional Autónoma de México
2015-2025
Autonomous University of Queretaro
2016-2023
Instituto Mexicano de Oftalmología IAP
2014
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in edema, vascular inflammation, coagulation, hallmarks this severe disease. However, mechanisms by which ECs are dysregulated COVID-19 unclear. Here, we show spike protein SARS-CoV-2 alone activates inflammatory phenotype manner dependent on integrin ⍺5β1 signaling. Incubation human umbilical vein with whole protein,...
Abstract Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits angiogenesis, vasopermeability, and vasodilation. Cathepsin D (CTSD) cleaves N-teminal PRL to generate vasoinhibin in retina neonate mice as revealed by CTSD inhibitor, pepstatin A (PA). However, PA also renin. Because renin expressed renin-angiotensin system (RAS) gives rise peptides with positive negative effects on blood vessel growth function, we investigated whether newborn mouse circulation. Newborn retinal...
Introduction Cancer cells drive the increase in vascular permeability mediating tumor cell extravasation and metastatic seeding. VIAN-c4551, an antiangiogenic peptide analog of vasoinhibin, inhibits growth vascularization melanoma tumors mice. Because VIAN-c4551 is a potent inhibitor permeability, we evaluated whether its antitumor action extended to reduction metastasis generation. Methods Circulating levels endothelial factor (VEGF), lung extravasation, pulmonary nodules were assessed...
Prolactin (PRL) levels are reduced in the circulation of rats with diabetes or obesity, and lower circulating PRL correlate increased prevalence a higher risk metabolic alterations clinic. Furthermore, stimulates β-cell proliferation, survival, insulin production pregnant mice lacking receptors β-cells develop gestational diabetes. To investigate protective effect endogenous against outside pregnancy, we compared number cases severity streptozotocin (STZ)-induced hyperglycemia between...
Purpose: High circulating levels of the hormone prolactin (PRL) protect against experimental diabetic retinopathy (DR) due to retinal accumulation vasoinhibin, a PRL fragment that inhibits blood vessel permeability and growth. A phase 2 clinical trial is investigating new therapy for DR based on elevating serum with levosulpiride, prokinetic dopamine D2 receptor blocker. Here, we tested whether levosulpiride-induced hyperprolactinemia elevates vasoinhibin in vitreous volunteer patients...
The hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous fragment of 123 or more amino acids that inhibits the action multiple proangiogenic factors. Preclinical clinical evidence supports therapeutic potential vasoinhibin against angiogenesis-related diseases including diabetic retinopathy, peripartum cardiomyopathy, rheumatoid arthritis, cancer. However, use in clinic has been limited by...
Age-related macular degeneration (AMD) is the leading cause of central vision loss and severe blindness among elderly population. Recently, we reported on association SGCD gene (encoding for δ-sarcoglycan) polymorphisms with AMD. However, functional consequence Sgcd alterations in retinal not known. Herein, characterized changes retina knocked-out mouse (KO, Sgcd−/−). At baseline, analyzed structure three-month-old wild-type (WT, Sgcd+/+) Sgcd−/− mice by hematoxylin eosin (H&E) staining,...
Excessive vasopermeability and angiogenesis compromise vision in diabetic macular oedema (DME) retinopathy (DR). Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits diabetes-induced retinal hypervasopermeability ischaemia-induced rodents. Hyperprolactinaemia generated by dopamine D2 receptor antagonist, levosulpiride, associated with higher levels vasoinhibin vitreous patients DR, implying beneficial outcome due to vasoinhibin-mediated inhibition vascular alterations....
Obesity leads to insulin resistance (IR) and type 2 diabetes. In humans, low levels of the hormone prolactin (PRL) correlate with IR, adipose tissue (AT) dysfunction, increased prevalence T2D. obese rats, PRL treatment promotes sensitivity reduces visceral AT adipocyte hypertrophy. Here, we tested whether elevating prokinetic antipsychotic drug sulpiride, an antagonist dopamine D2 receptors, improves metabolism in high fat diet (HFD)-induced male mice. Sulpiride (30 days) reduced...
The hormone prolactin (PRL) is emerging as an important regulator of ocular blood vessels. PRL pro-angiogenic and acquires anti-angiogenic properties after undergoing proteolytic cleavage to the fragment, vasoinhibin. vascularisation rodent retina develops birth when it rapidly expands until completion at end first postnatal week. Exposure newborn mice high oxygen levels lowers rate vessel growth. In present study, we investigated whether treatment modifies in exposed or normoxia retinal...
Abstract Background/Objective The prokinetic levosulpiride elevates vasoinhibin levels in the vitreous of patients with proliferative diabetic retinopathy (PDR) suggesting clinical benefits due to anti-vasopermeability and anti-angiogenic properties vasoinhibin. We investigated biological activity centre-involving macular oedema (DME). Patients/Methods Prospective, randomized, double-blinded, dual-centre, phase 2 trial DME orally treated placebo ( n = 17) or for 8 weeks PDR undergoing...
Abstract VIAN-c4551 is a cyclic antiangiogenic peptide that stands as potent and stable inhibitor of vascular endothelial cell growth factor (VEGF), the major vasopermeability angiogenic in diabetic macular edema retinopathy. Intravitreal injections inhibitors VEGF are first-line therapy, but invasiveness, risk, low adherence frequent intravitreal interfere with needed long-term treatments successful outcomes. Eye drops non-invasive favor compliance. Here, we evaluated preclinical efficacy,...
ABSTRACT Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits angiogenesis, vasopermeability, and vasodilation. Cathepsin D (CTSD) cleaves N-teminal PRL to generate vasoinhibin in retina neonate mice as revealed by CTSD inhibitor, pepstatin A (PA). However, PA also renin. Because renin expressed renin-angiotensin system (RAS) gives rise peptides with positive negative effects on blood vessel growth function, we investigated whether newborn mouse circulation. Newborn retinal...
Introduction: Cancer cells drive the increase in vascular permeability mediating tumor cell extravasation and metastatic seeding. VIAN-c4551, an antiangiogenic peptide analog of vasoinhibin, inhibits growth vascularization melanoma tumors mice. Because VIAN-c4551 is a potent inhibitor permeability, we evaluated whether its antitumor action extended to reduction metastasis generation. Methods: Circulating levels endothelial factor (VEGF), lung extravasation, pulmonary nodules were assessed...
Abstract Disclosure: C. Clapp: None. C.D. Núñez-Amaro: M. López: E. Adán-Castro: Robles Osorio: R. García-Franco: García-Roa: Y. Villalpando: P. Ramírez-Neria: N. Pineiro: J.F. Rubio-Mijangos: J. Sánchez: G. Ramirez-Hernandez: L. Siqueiros-Márquez: Díaz-Lezama: López-Star: T. Bertsch: Martínez de la Escalera: Triebel: Vasoinhibin is a fragment of prolactin that inhibits the permeability and growth blood vessels. The prokinetic dopamine D2 receptor blocker, levosulpiride, elevates circulating...
Retinopathy of prematurity (ROP) is a potentially blinding retinal neovascular disease. Prolactin (PRL) circulating levels are higher in ROP than control patients and such imbalance predictive risk variable for that may impact disease progression (Zepeda-Romero et al. Pediatric Res 2017). PRL accesses the retina from systemic circulation pro-angiogenic but can be cleaved into anti-angiogenic fragments (vasoinhibin). Like preterm infants, newborn mice have incomplete vascularization at birth...