A5061649429- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Hip and Femur Fractures
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Infectious Diseases and Tuberculosis
- Advanced materials and composites
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Knee injuries and reconstruction techniques
- Acute Myeloid Leukemia Research
- Bone health and treatments
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Musculoskeletal synovial abnormalities and treatments
- Sarcoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Infective Endocarditis Diagnosis and Management
- Bone health and osteoporosis research
- IL-33, ST2, and ILC Pathways
- Cardiac, Anesthesia and Surgical Outcomes
University of Oxford
2010-2024
Nuffield Orthopaedic Centre
2014-2024
Science Oxford
2021
Orthopaedic Center
2021
Oxford University Hospitals NHS Trust
2019
NIHR Oxford Musculoskeletal Biomedical Research Centre
2016
Marymount University
2008
Leeds General Infirmary
2000
Public Health Institute
2000
The University of Adelaide
1997
We report 17 patients (20 hips) in whom metal-on-metal resurfacing had been performed and who presented with various symptoms a soft-tissue mass which we termed pseudotumour. Each patient underwent plain radiography some, CT, MRI ultrasonography were also performed. In addition, histological examination of available samples was undertaken. All the women their presentation variable. The most common symptom discomfort region hip. Other included spontaneous dislocation, nerve palsy, noticeable...
The management of complex orthopedic infections usually includes a prolonged course intravenous antibiotic agents. We investigated whether oral therapy is noninferior to for this indication.
We describe treatment failure rates by antibiotic duration for prosthetic joint infection (PJI) managed with debridement, antibiotics and implant retention (DAIR). retrospectively collected data from all the cases of PJI that were DAIR over a 5 year period. Surgical microbiological sampling, early intravenous prolonged oral follow-on used. One hundred twelve identified. Twenty infections (18%) recurred during mean follow-up 2.3 years. The use was 1.5 Failure more common after arthroscopic...
Inflammatory pseudotumours occasionally occur after metal-on-metal hip resurfacing and often lead to revision. Our aim was determine the severity of this complication by assessing outcome revision in these circumstances comparing with other revisions as well that matched primary total replacements. We identified 53 hips which had undergone required at a mean 1.59 years (0.01 6.69) operation. Of these, 16 were revised for pseudotumours, 21 fracture reasons. These age, gender diagnosis 103...
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations, most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage through mechanisms that remain unclear. To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human bone marrow (BM) samples. Most of selective mutant occurs within HSCs. DNMT3A- TET2-mutant clones expand further early progenitors, while...
Abstract Human NK cells may be divided into a CD56dim subset and CD56bright subset. In peripheral blood, dominate, whereas in lymph nodes, are more common. this study we show that accumulate within inflammatory lesions wide variety of clinical diseases affecting several different anatomical sites. We demonstrate when activated by the monokines IL-12, IL-15, IL-18, these promote TNF-α production CD14+ monocytes manner is dependent on cell:cell contact. Conversely, synergize with to IFN-γ...
We describe rates of success for two-stage revision prosthetic joint infection (PJI), including data on reimplantation microbiology. retrospectively collected from all the cases PJI that were managed with over a 4 year period. Patients an antibiotic-free period before reimplantation, in order to confirm, clinically and microbiologically, was successfully treated. One hundred fifty-two identified. The overall rate (i.e. retention prosthesis 5.75 years follow-up) 83%, but 89% first revisions...
Few independent studies have reported the outcome of resurfacing arthroplasty hip. The aim this study was to report five-year clinical and seven-year survival an series. A total 610 Birmingham Hip Resurfacing arthroplasties were performed in 532 patients with a mean age 51.8 years (16.5 81.6). They followed for between two eight years; 107 (120 hips) had been up more than five years. Two lost follow-up. At minimum years' follow-up, 79 85 hips (93%) excellent or good according Harris hip...
We present the histological findings of bone retrieved from beneath femoral components failed metal-on-metal hip resurfacing arthroplasties. Of a total 377 patients who underwent arthroplasty, 13 required revision; for fracture neck in eight, loosening component three and other reasons two. None these cases had shown evidence osteonecrosis at time initial implantation. Bone remnant head showed changes all but one case revision. In two which occurred within week implantation, were compatible...
Pseudotumours are a rare complication of hip resurfacing. They thought to be response metal debris which may caused by edge loading due poor orientation the acetabular component. Our aim was determine optimal minimise risk pseudotumour formation. We matched 31 resurfacings revised for formation with 58 controls who had satisfactory outcome from this procedure. The radiographic inclination and anteversion angles component were measured on anteroposterior radiographs pelvis using...
The use of highly crosslinked polyethylene (HXLPE) is now commonplace for total hip arthroplasty. Hip simulator studies and short-term in vivo measurements suggest that the wear rate some types HXLPE significantly less than conventional ultrahigh-molecular-weight (UHMWPE). However, there are few long-term data to support its use.The aim this study was measure steady-state compared with UHMWPE liners a prospective, double-blind, randomized controlled trial using radiostereometric...
Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers GM-CSF-producing CD4 and CD8 lymphocytes in the blood joints patients with spondyloarthritis, IL-17A+GM-CSF+ double-producing CD4, CD8, γδ NK cells. GM-CSF production T cells occurs both independently combination classical Th1 Th17 cytokines. Type 3 innate lymphoid producing predominantly are expanded synovial tissues from...
Recent events have highlighted the importance of implant design for survival and wear-related complications following metal-on-metal hip resurfacing arthroplasty. The mid-term most widely used implant, Birmingham Hip Resurfacing (BHR), has been described by its designers. aim this study was to report ten-year patient-reported functional outcome BHR from an independent centre. In cohort 554 patients (646 BHRs) with a mean age 51.9 years (16.5 81.5) followed eight (1 12), depended on gender...
Aims Advocates of debridement, antibiotics and implant retention (DAIR) in hip periprosthetic joint infection (PJI) argue that a procedure not disturbing sound prosthesis-bone interface is likely to lead better survival functional outcome compared with revision. This case-control study aims were compare DAIRs for infected primary total arthroplasty (THA) outcomes following THA two-stage revision THAs. Patients Methods We retrospectively reviewed all DAIRs, performed confirmed arthropasty (n...
Background Management of bone and joint infection commonly includes 4–6 weeks intravenous (IV) antibiotics, but there is little evidence to suggest that oral (PO) therapy results in worse outcomes. Objective To determine whether or not PO antibiotics are non-inferior IV treating infection. Design Parallel-group, randomised (1 : 1), open-label, non-inferiority trial. The margin was 7.5%. Setting Twenty-six NHS hospitals. Participants Adults with a clinical diagnosis bone, orthopaedic...
The Oxford hip score (OHS) is a patient-based instrument for assessment of outcome which often used after total replacement, and the EuroQol 5D (EQ5D) generic questionnaire health assessment. In an analysis at one year 609 revision replacements (RHRs), we compared OHS EQ5D scores, postoperative patient satisfaction change in pain. About 25% operations were repeat RHRs. At year, 57% patients very pleased with their operation. correlation between preoperative scores was high. For both...
Abstract Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations in genes, including DNMT3A and TET2 , conferring a competitive advantage through mechanism that remains unclear. To gain insight into how CH enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on bone marrow samples. Most of the selective mutant occurs within HSCs. -mutant clones expand further early progenitors, while accelerate myeloid maturation...
The most conspicuous function of the osteoblast is formation bone. During phases active bone formation, osteoblasts synthesize matrix and prime it for subsequent mineralization. Active are plump, cuboidal cells rich in organelles involved synthesis secretion proteins. Unlike fibroblasts, they obviously polarized, secreting onto underlying bony substratum which consequently grows by apposition. Some engulfed during entombed lacunae. These described as osteocytes remain a state low metabolic...
Summary The elastic properties of cells can be measured with microscopic resolution by acoustic microscopy. By measuring the waveform very short pulses, thickness, and velocity, impedance attenuation determined from two separate signals reflected top bottom cell.