Claire Scarborough
A5018398480- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Surgical site infection prevention
- Gut microbiota and health
- Neutropenia and Cancer Infections
- Tuberculosis Research and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Orthopaedic implants and arthroplasty
- Diverticular Disease and Complications
- Appendicitis Diagnosis and Management
- Delphi Technique in Research
- Infectious Diseases and Tuberculosis
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Climate Change and Health Impacts
- Sepsis Diagnosis and Treatment
- Microscopic Colitis
- Infective Endocarditis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Thermal Regulation in Medicine
University of Oxford
2019-2024
Oxford University Hospitals NHS Trust
2019-2024
The Royal Free Hospital
2024
Anthony Nolan
2024
University College London
2024
Nuffield Orthopaedic Centre
2022-2023
Oxford Health NHS Foundation Trust
2021
The management of complex orthopedic infections usually includes a prolonged course intravenous antibiotic agents. We investigated whether oral therapy is noninferior to for this indication.
Background Management of bone and joint infection commonly includes 4–6 weeks intravenous (IV) antibiotics, but there is little evidence to suggest that oral (PO) therapy results in worse outcomes. Objective To determine whether or not PO antibiotics are non-inferior IV treating infection. Design Parallel-group, randomised (1 : 1), open-label, non-inferiority trial. The margin was 7.5%. Setting Twenty-six NHS hospitals. Participants Adults with a clinical diagnosis bone, orthopaedic...
Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess incidence and risk factors for treatment failure (TF) Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome.A retrospective cohort study SA-PJI was performed in 19 European hospitals between 2014 2016. The outcome variable TF, related mortality, clinical loss both after initial surgical procedure all procedures at 18 months....
The aim of this study was to estimate the incidence, associated disease burden and healthcare utilization due Staphylococcus aureus prosthetic joint infections (SA-PJI) after primary hip knee arthroplasty in European centres.This conducted patients who underwent 19 hospitals between 2014 2016. global incidence PJI SA-PJI calculated. measured indirectly as infection-related mortality plus loss function. For utilization, number duration hospitalizations, type surgical procedures, antibiotic...
Better metrics to compare the impact of different antimicrobials on gut microbiome would aid efforts control antimicrobial resistance (AMR).The Antibiotic Resistance in Microbiome – Oxford (ARMORD) study recruited inpatients, outpatients and healthy volunteers Oxfordshire, UK, who provided stool samples for metagenomic sequencing. Data previous use potential confounders were recorded. Exposures each considered as factors a multivariable linear regression, also adjusted demographics, with...
Better metrics to compare the impact of different antimicrobials on gut microbiome would aid efforts control antimicrobial resistance (AMR).The Antibiotic Resistance in Microbiome – Oxford (ARMORD) study recruited inpatients, outpatients and healthy volunteers Oxfordshire, UK, who provided stool samples for metagenomic sequencing. Data previous use potential confounders were recorded. Exposures each considered as factors a multivariable linear regression, also adjusted demographics, with...
Abstract Background Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. The aim of this study was to describe the clinical characteristics patients cIAI in a multicentre develop prediction models (CPMs) help identify at risk mortality or relapse. Methods A observational conducted from August 2016 February 2017 UK. Adult diagnosed were included. Multivariable logistic regression performed CPMs for c-statistic used test model discrimination....
Abstract Background Better metrics to compare the impact of different antimicrobials on gut microbiome would aid efforts control antimicrobial resistance (AMR). Methods The Antibiotic Resistance in Microbiome – Oxford (ARMORD) study recruited inpatients, outpatients and healthy volunteers Oxfordshire, UK, who provided stool samples for metagenomic sequencing. Data previous use potential confounders were recorded. Exposures each considered as factors a multivariable linear regression, also...
Aim The SOLARIO trial is a randomised controlled non-inferiority of antibiotic strategy for bone and joint infection. compares short or long post-operative systemic duration, patients with confirmed infections, who had local antibiotics implanted no infected metalwork retained when undergoing surgery. This analysis compared use in the (intervention) (standard care) arms trial, 12 months after index Method Data was collected prospectively from study randomisation, within 7 days All prescribed...
Aim People awaiting surgery for bone and joint infection may be recommended to stop smoking improve anaesthetic surgical outcomes. However, restricting curative treatment non-smokers on the basis of potentially worse outcomes is not validated functional or quality life differences between patients who do smoke. This study used secondary analysis trial data ask: peri-operative have a greater improvement in their 12 months after infection, compared with non-smokers? Method Participants SOLARIO...