A5012785219- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Spine and Intervertebral Disc Pathology
- Connective tissue disorders research
- Cerebral Palsy and Movement Disorders
- Spinal Fractures and Fixation Techniques
- Bone health and treatments
- Traumatic Brain Injury Research
- Automotive and Human Injury Biomechanics
- Bone fractures and treatments
- Trauma and Emergency Care Studies
- Bone Tumor Diagnosis and Treatments
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Total Knee Arthroplasty Outcomes
- Pregnancy-related medical research
- Shoulder Injury and Treatment
- Medical Imaging and Pathology Studies
- Agriculture and Farm Safety
- Bone Metabolism and Diseases
- Traffic and Road Safety
- Pelvic and Acetabular Injuries
Bristol Royal Hospital for Children
2009-2025
Hospital for Sick Children
2017-2024
University of Toronto
2017-2024
University Hospitals Bristol NHS Foundation Trust
2009-2020
Bristol Hospital
2019
Institute for Clinical Evaluative Sciences
2017
Bristol Royal Infirmary
2003-2015
University of Bristol
1991-2012
Southmead Hospital
1991-2008
Royal Hospital for Sick Children
2000-2006
Background: Hemiarthroplasty and total hip arthroplasty are commonly used to treat displaced intracapsular fractures of the femoral neck, but each has disadvantages optimal treatment these remains controversial. Methods: In present prospectively randomized study, eighty-one patients who had been mobile lived independently before they sustained a fracture neck were receive either or hemiarthroplasty. The mean age was seventy-five years. Outcome assessed with use Oxford score, final...
We reviewed the seven- to ten-year results of our previously reported prospective randomised controlled trial comparing total hip replacement and hemiarthroplasty for treatment displaced intracapsular fracture femoral neck. Of original study group 81 patients, 47 were still alive. After a mean follow up nine years (7 10) overall mortality was 32.5% 51.2% after hemiarthroplasty, respectively (p = 0.09). At 100 months postoperatively significantly greater proportion patients had died 0.026)....
We studied 50 consecutive patients presenting at an accident department after rear-end vehicle collisions and recorded symptoms psychological test scores within one week of injury, three months two years. The range neck movement was noted months. Within were normal in 82% the group but became abnormal 81% with intrusive or disabling over (p < 0.001) remained 69% clinical outcome years could be predicted 76% accuracy by stiffness, 74% score a combination these variables. severity whiplash...
Developmental dysplasia of the hip (DDH) is most common skeletal developmental disease. However, its genetic architecture poorly understood. We conduct largest DDH genome-wide association study to date and replicate our findings in independent cohorts. find heritable component attributable variants be 55% distributed equally across autosomal X-chromosomes. identify replicating evidence for between GDF5 promoter variation (rs143384, effect allele A, odds ratio 1.44, 95% confidence interval...
Forty patients with a whiplash injury who had been reviewed previously 2 and 10 years after were assessed again mean of 15.5 by physical examination, pain psychometric testing. Twenty-eight (70%) continued to complain symptoms referable the original accident. Neck was commonest, but low-back present in half. Women older worse outcome. Radiating more common those severe symptoms. Evidence psychological disturbance seen 52% Between 15 accident 18% improved whereas 28% deteriorated.
Abstract Polymorphonuclear neutrophils (PMNs) are the most abundant circulating leukocytes, and first cells recruited to sites of tissue inflammation. Using a fixation method preserve native CD marker expression prior immunophenotyping, we identified distinct population “primed for recruitment” PMNs in healthy mouse human blood that has high adhesion activation markers compared with bulk resting-state PMNs. In response acute inflammation, primed (pPMNs) were rapidly depleted from circulation...
Background: Hemiarthroplasty and total hip arthroplasty are commonly used to treat displaced intracapsular fractures of the femoral neck, but each has disadvantages optimal treatment these remains controversial. Methods: In present prospectively randomized study, eighty-one patients who had been mobile lived independently before they sustained a fracture neck were receive either or hemiarthroplasty. The mean age was seventy-five years. Outcome assessed with use Oxford score, final...
Abstract Introduction Children with developmental hip dislocation (DDH) that have failed closed reduction or presented late may be treated open either via the medial approach (MOR), a delayed anterolateral (AOR) approach. There is no consensus on which provides better outcomes. This updated prospective cohort study aims to compare approaches at long term follow up. Methods Thirty hips in 25 children (MOR) and 19 18 who were for DDH our centre identified. All patients included had reached...
The medial approach for the treatment of children with developmental dysplasia hip (DDH) in whom closed reduction has failed requires minimal access negligible blood loss. In United Kingdom, there is a preference these to be treated using an anterolateral after appearance ossific nucleus. this study we compared two protocols, primarily risk osteonecrosis. Data were gathered prospectively protocols involving (26 hips 22 children) and (22 21 aged < 24 months at time surgery. Osteonecrosis...
Brace treatment is the cornerstone of managing developmental dysplasia hip (DDH), yet there a lack evidence-based protocols, which results in wide variations practice. To resolve this, we have developed comprehensive nonoperative protocol conforming to published consensus principles, with well-defined priori criteria for inclusion and successful treatment.This was single-centre, prospective, longitudinal cohort study consecutive series infants ultrasound-confirmed DDH who underwent brace...
Forty patients with a whiplash injury who had been reviewed previously 2 and 10 years after were assessed again mean of 15.5 by physical examination, pain psychometric testing. Twenty-eight (70%) continued to complain symptoms referable the original accident. Neck was commonest, but low-back present in half. Women older worse outcome. Radiating more common those severe symptoms. Evidence psychological disturbance seen 52% Between 15 accident 18% improved whereas 28% deteriorated.
We studied 50 consecutive patients presenting at an accident department after rear-end vehicle collisions and recorded symptoms psychological test scores within one week of injury, three months two years. The range neck movement was noted months.
Of 586 employed patients with a whiplash injury 40 (7%) did not return to work. The risk was increased by three times in heavy manual workers, two and half prior psychological symptoms doubled for each increase of grade disability. length time off work history trebled self-employed were as likely take work, but recovered significantly more slowly than employees.
We assessed the long-term outcomes of a large cohort patients who have undergone periacetabular osteotomy (PAO), and sought to validate patient satisfaction questionnaire for use in PAO cohort.All had from July 1998 February 2013 were surveyed, with several patient-reported outcome measures (PROMs) radiological measurements preoperative acetabular dysplasia postoperative correction also recorded. Patients asked rate their level operation achieving pain relief, restoration activities daily...
We studied 50 consecutive patients presenting at an accident department after rear-end vehicle collisions and recorded symptoms psychological test scores within one week of injury, three months two years. The range neck movement was noted months. Within were normal in 82% the group but became abnormal 81% with intrusive or disabling over (p < 0.001) remained 69% clinical outcome years could be predicted 76% accuracy by stiffness, 74% score a combination these variables. severity whiplash...
When cerebral palsy involves the entire body pelvic asymmetry indicates that both hips are 'at risk'. We carried out a six-year retrospective clinical, radiological and functional study of 30 children (60 hips) with severe involving to evaluate whether bilateral simultaneous combined soft-tissue bony surgery hip could affect range movement, achieve symmetry as judged by windsweep index, improve indices containment, relieve pain, handling function. The early results at median follow-up three...
The results of a functional, clinical and radiological study 30 children (60 hips) with whole-body cerebral palsy were reviewed at mean follow-up 10.2 years (9.5 to 11). Correction windsweep deformity the hips was performed by bilateral simultaneous combined soft-tissue bony surgery age 7.7 (3.1 12.2). We able recall 22 patients; five had died unrelated causes three lost follow-up. Evaluation involved interviews patients/carers examination. gross motor functional classification system used...