A5088975071- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Infective Endocarditis Diagnosis and Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Infections and bacterial resistance
- Salmonella and Campylobacter epidemiology
- Urinary Tract Infections Management
- Veterinary medicine and infectious diseases
- Bacterial Genetics and Biotechnology
- Helicobacter pylori-related gastroenterology studies
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Escherichia coli research studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial infections and disease research
- Bacteriophages and microbial interactions
The University of Adelaide
2008-2024
University of South Australia
2021
Act Health
2020
South Australia Pathology
2009-2018
Women's and Children's Hospital
2006-2016
Australian Commission on Safety and Quality in Health Care
2016
Royal Perth Hospital
2014
Boston Children's Hospital
2002-2012
Babson College
2007
CNR de la Résistance aux Antibiotiques
1999
Between January 1997 and December 1999, bloodstream isolates from 15,439 patients infected with Staphylococcus aureus 6350 coagulase-negative species (CoNS) were referred by SENTRY-participating hospitals in the United States, Canada, Latin America, Europe, Western Pacific region. S. was found to be most prevalent cause of infection, skin soft-tissue pneumonia almost all geographic areas. A notable increase methicillin (oxacillin) resistance among community-onset hospital-acquired strains...
ABSTRACT Multiple methicillin-resistant Staphylococcus aureus (MRSA) clones carrying type IV staphylococcal cassette chromosome mec were identified in the community-acquired MRSA strains of both United States and Australia. They multiplied much faster than health-care-associated resistant to fewer non-beta-lactam antibiotics. seem have been derived from more diverse S. populations strains.
Antimicrobial resistance in Staphylococcus aureus is a major public health threat, compounded by emergence of strains with to vancomycin and daptomycin, both last line antimicrobials. Here we have performed high throughput DNA sequencing comparative genomics for five clinical pairs vancomycin-susceptible (VSSA) vancomycin-intermediate ST239 S. (VISA); each pair isolated before after treatment failure. These comparisons revealed frequent pattern mutation among the VISA within essential walKR...
ABSTRACT Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli , Enterobacter cloacae and Klebsiella pneumoniae strains) isolated in 2006 2007 India, 15 strains carried bla NDM-1 10 harbored a gene encoding variant of the carbapenemase OXA-48, named OXA-181 . One E. strain VIM-6 one K. carrying also possessed VIM-5 Multiple pulsed-field gel electrophoresis patterns clonal dissemination within among sites were observed. Isolates producing disseminated Indian health...
Enterococci with resistance to glycopeptides have recently emerged in Australia. We developed multiplex PCR assays for vanA, vanB, vanC1, and vanC2 or vanC3 order examine the genetic basis vancomycin Australian isolates of vancomycin-resistant Enterococcus faecium E. faecalis (VRE). The predominant genotype from human clinical was vanB. van consistent phenotype all but six cases. One vanA isolate had a VanB phenotype, one vanB VanA four were consistently negative vanC3, even though they...
The clinical utility of carbapenems is under threat because the emergence acquired metallo-beta-lactamase (MBL) genes. We describe first outbreak in Australia infection and/or colonization with gram-negative pathogens carrying MBL gene blaIMP-4.MBL-producing organisms were identified using susceptibility data conjunction screening methods. PCR and sequence analysis performed to characterize resistance identify presence integrons. DNA profiles determined by ribotyping. Clinical...
BackgroundResistance to colistin is emerging in multidrug-resistant Gram-negative bacteria and no solid pharmacodynamic data are available for against Klebsiella pneumoniae.
The aim of this study was to evaluate the occurrence and dissemination acquired carbapenem-hydrolysing class D β-lactamase (class carbapenemase)- metallo-β-lactamase (MBL)-encoding genes among Acinetobacter spp. isolates recovered from medical centres in Asia-Pacific (APAC) region. During 2006–07, 41 located 10 countries APAC region forwarded a central monitoring site 544 isolates, which were tested for susceptibility by reference broth microdilution method. Isolates non-susceptible imipenem...
Clinical utility of carbapenem antibiotics is under threat because the emergence acquired metallo-β-lactamase (MBL) genes. We describe an outbreak in intensive care unit (ICU) possibly associated with contaminated sinks.Four clusters gram-negative bacteria harbouring MBL gene blaIMP-4 were detected ICU at Dandenong Hospital between November 2009 and July 2012. Epidemiological investigations undertaken order to identify a common point source. During September 2012, screening using rectal...
ABSTRACT Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 μg/ml) and full susceptibility teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal genotypes ( vanA , vanB vanC vanD vanE ). We have isolated sequenced novel putative locus (designated vanG ), which contains seven open reading frames, from this strain. These are organized differently those the other van loci, and, furthermore, individual gene...
ABSTRACT Increasing reports of the appearance novel nonmultiresistant methicillin-resistant Staphylococcus aureus MRSA (MRSA) strains in community and spread hospital into are cause for public health concern. We conducted two national surveys unique isolates S. from clinical specimens collected nonhospitalized patients commencing 2000 2002, respectively. A total 11.7% 2,498 15.4% 2,486 2002 were MRSA. Approximately 54% (resistant to less than three nine antibiotics) both surveys. The...
As part of the SENTRY antimicrobial surveillance program, we examined prevalence rates, types, and antibiograms oxacillin-resistant Staphylococcus aureus from hospitalized patients 17 institutions in eight countries Asia-Pacific South Africa (APAC). From April 1998 to December 1999, a total 1,711 isolates S. (814 blood, 392 respiratory tract, 467 skin structures, 38 urine) were collected within APAC region. Multidrug-resistant (MORSA) isolates, defined as strains with three or more...
Three clinical Pseudomonas aeruginosa isolates (WCH2677, WCH2813, and WCH2837) isolated from the Women's Children's Hospital, Adelaide, Australia, produced a metallo-β-lactamase (MBL)-positive Etest result. All were PCR negative for known MBL genes. A gene bank was created, an gene, designated bla(AIM-1), cloned fully characterized. The encoded enzyme, AIM-1, is group B3 that has highest level of identity to THIN-B L1. It chromosomal flanked by two copies (one intact one truncated) ISCR...
Among 4,167 Staphylococcus aureus and 790 coagulase-negative (CoNS; not S. saprophyticus) isolates collected consecutively from North American Australian hospitals, only 87 (1.7% overall) displayed a fusidic acid (FA; also known as CEM-102) MIC of > or = 2 microg/ml (FA resistance). These strains were further evaluated with multiplex PCR to amplify the acquired resistance genes fusB, fusC, fusD. Mutations in fusA fusE all showing an absence and/or FA values 64 microg/ml. rates very low...
The Regional Resistance Surveillance program monitored susceptibility rates and developing resistance by geographic region, including 12 Asia-Pacific (APAC) countries. Reference broth microdilution methods for susceptibility/interpretations were applied, processing 5,053 strains. Among Staphylococcus aureus isolates (37% methicillin-resistant S. [MRSA], highest in South Korea [73%]), linezolid (LZD), tigecycline (TIG), vancomycin 100% active, but 33 34% of strains levofloxacin (LEV) or...
Unlike Escherichia coli strains belonging to phylogroup B2, the clinical significance of F is not well understood. Here we report on a collection recovered in Australia from faeces and extra-intestinal sites humans, companion animals native animals, as poultry meat water samples. The distribution sequence types was clearly non-random with respect isolate source. antimicrobial resistance virulence trait profiles also varied type isolate. Phylogroup tended lack traits typically associated B2...
ABSTRACT Ertapenem (MK-0826, L-749,345) is a 1-β-methyl carbapenem with long serum half-life. Its in vitro activity was determined by broth microdilution against 3,478 bacteria from 12 centers Europe and Australia, imipenem, cefepime, ceftriaxone, piperacillin-tazobactam used as comparators. the most active agent tested members of family Enterobacteriaceae , MICs at which 90% isolates are inhibited (MIC 90 s) ≤1 μg/ml for all species. also more than imipenem fastidious gram-negative...
Dalbavancin, a long-acting lipoglycopeptide, was evaluated against 81,673 isolates of staphylococci, enterococci, and streptococci collected from 33 countries during worldwide resistance surveillance (2002 to 2007). Regardless susceptibility oxacillin, comparable potencies for dalbavancin Staphylococcus aureus coagulase-negative staphylococci all were noted (MIC(90), 0.06 0.12 microg/ml). Vancomycin-susceptible Enterococcus spp. had MIC(90)s those whereas vancomycin-resistant strains more...
This study investigated the frequency of antimicrobial non-susceptibility (defined as isolates with minimum inhibitory concentrations above CLSI susceptible clinical breakpoint) among E. coli and Salmonella spp. isolated from healthy Australian finisher pigs. (n = 201) 69) were cecal contents slaughter-age pigs, originating 19 farms distributed throughout Australia during July-December 2015. Isolates underwent concentration (MIC) susceptibility testing to 11 antimicrobials. The highest...
Abstract Background The incidence, risks and organisms causing bloodstream infections (BSI) differ between children adults due to distinct comorbidities, procedures antibiotic exposures. Age-specific data are required inform targeted interventions, empiric treatment guideline development. We aimed compare the risk factors resistance patterns of bacteria BSI in (2020-21). Methods Australian Group on Antimicrobial Resistance (AGAR) is a national hospital-based surveillance program reporting...
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance selected enteric gram-negative pathogens. From 1 January 2023 31 December 2023, a total of 57 hospitals across Australia participated the Gram-negative Surveillance Outcome Program (GnSOP). survey tested 10,453 isolates, comprising Enterobacterales (9,503; 90.9%), P. aeruginosa (806; 7.7%) and Acinetobacter species (144; 1.4%), using commercial...