A5018522450- Neonatal Respiratory Health Research
- Global Maternal and Child Health
- Infant Development and Preterm Care
- Child Nutrition and Water Access
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Hemoglobinopathies and Related Disorders
- Neonatal and Maternal Infections
- Breastfeeding Practices and Influences
- Retinopathy of Prematurity Studies
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Maternal and Neonatal Healthcare
- Preterm Birth and Chorioamnionitis
- Malaria Research and Control
- Iron Metabolism and Disorders
- Streptococcal Infections and Treatments
- Anesthesia and Neurotoxicity Research
- Migration, Identity, and Health
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Viral Infections and Vectors
- Emergency and Acute Care Studies
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
Nsambya Hospital
2009-2025
Uganda Martyrs University
2015-2024
University of Chicago
2024
Mount Sinai Hospital
2022
University of Toronto
2022
KU Leuven
2022
Europe Hospitals
2022
British Columbia Children's Hospital
2022
Hospital for Sick Children
2022
SickKids Foundation
2022
Abstract Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported many countries following early COVID-19 pandemic response measures (‘lockdowns’). It unclear whether this variation reflects real differences lockdown impacts, or perhaps stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data 52 million births 26 countries, 18 which had representative...
BackgroundIn Uganda maternal and neonatal mortality remains high due to a number of factors, including poor quality care at health facilities.ObjectiveThis paper describes the experience building capacity for newborn district hospital lower-level facilities in eastern within existing system parameters robust community outreach programme.DesignThis strengthening study, part Newborn Study (UNEST), aimed increase frontline worker through district-led training, support supervision, mentoring one...
Hypoxic Ischemic Encephalopathy carries high case fatality rates ranging between 10–60%, with 25% of survivors have an adverse long-term neurodevelopment outcome. Despite the above, there is paucity data regarding its magnitude and short term outcomes in a low resource setting like Uganda. Therefore we set out to determine incidence Newborns at St.Francis Hospital, Nsambya. This was Prospective Cohort study conducted October 2015 January 2016 St. Francis Nsambya, Kampala- Term Newborn babies...
The successful promotion of facility births in low and middle-income countries has not always resulted improved neonatal outcome. We evaluated key signal functions pertinent to Level II care determine readiness for high risk/ small sick newborns.Facility babies was determined through self-evaluation using a pre-designed checklist selected referral hospitals Uganda (10), Indonesia (4) India (2) with focus on the Sub-Saharan country greater challenges.Most facilities reported having continuous...
Introduction: We assessed the risk of adverse pregnancy and birth outcomes defects among women living with HIV (WLHIV) on antiretroviral therapy (ART) HIV-negative women. Methods: analyzed data live births, stillbirths, spontaneous abortions during 2015–2021 from a hospital-based surveillance system in Kampala, Uganda. ART regimens were recorded hospital records maternal self-reports. Using log-binomial regression model, we compared prevalence 16 major external other WLHIV Results: A total...
Introduction: Neurodevelopmental delay has been reported among preterm infants who survive beyond the neonatal period. However, there is paucity of data regarding neurodevelopmental outcomes in Africa, including Uganda. Objectives; This study aimed at determining prevalence and factors associated with neurodevelopment (NDD) aged 6 to 24 months adjusted gestation age. Methods; A cross-sectional was conducted 206 infants, between age follow up clinics St. Francis Hospital Nsambya Mulago...
Background The World Health Organization (WHO) strongly recommends the use of donor human milk (DHM) for low birth weight infants when mother’s own is unavailable or insufficient. However, DHM requires availability banks (HMBs), majority which are in middle and high-income countries. Developing countries offer multiple opportunities challenges regarding establishment operationalization HMBs. This study describes experience setting up HMB Uganda at St. Francis Hospital Nsambya. Methods first...
Background: The perinatal mortality of 70 deaths per 1,000 total births in Uganda is unacceptably high. Perinatal death audits are important for improvement care and reduction morality. We integrated routine care, describe its effect on rate at Nsambya Hospital.Methods: This was a retrospective descriptive study conducted from March – November 2008. An interdisciplinary hospital team weekly reviews. Each case summarized discussed, identifying gaps cause death. Local solutions were...
With targeted management of neonatal hyperbilirubinaemia in high-income countries, there has been a drastic drop both the prevalence and mortality. On contrary, over two-thirds global burden is Sub-saharan Africa South East Asia with high mortality risk 16-35%. Neonatal not leading cause mortality, however leads to irreversible neurological damage death when managed poorly. Three-quarters babies admitted national referral hospital Uganda had significant hyperbilirubinaremia; 16.6% these...
Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these despite unacceptably levels of resistance. Intermittent presumptive treatment sulphadoxine-pyrimethamine (SP) has shown great potential reducing prevalence malaria and anaemia pregnant women infants. To compare the efficacy monthly SP treatment, versus weekly attending Sickle Cell Clinic, Mulago Hospital. Two hundred forty two were randomized to or prophylaxis....
Donated breast milk is considered beneficial to vulnerable infants. Thus, Uganda launched its first human bank in November 2021 provide preterm, low birthweight and sick babies. However, there a scarcity of information on the acceptability donated Uganda. The study sought assess using associated factors among pregnant women at private public hospital central Uganda.This cross-sectional enrolled attending antenatal care selected hospitals between July October 2020. All recruited had already...
Breast milk is crucial for the nutritional and developmental milestones in first two years of life. Uganda has recognized need a human bank as an opportunity that offers reliable healthy to babies who lack access their mothers. However, there little information on perceptions towards donated breast Uganda. This study aimed explore mothers, fathers, health workers use at Nsambya Naguru hospitals Kampala district, central Uganda.A qualitative descriptive was conducted The consisted 8 focus...
Uganda has just experienced the largest outbreak of Ebola haemorrhagic fever (EHF) ever recorded. Mbarara University Teaching Hospital (MUTH) is responsible for training approximately one-third Uganda's doctors. located in South West Uganda, 614 km from Gulu, main epicentre outbreak. On 23 October a patient was admitted to medical ward MUTH with an acute fever. He soon exhibited symptoms and died. later confirmed have suffered Ebola. Three more patients subsequently contracted disease. All...
To assess the effects of perinatal death (PND) audit on outcomes in a tertiary hospital Kampala.
<title>Abstract</title> <bold>Background</bold> Continuous Positive Airway Pressure (CPAP) is a low-cost treatment modality for respiratory distress syndrome that has been shown to improve survival of preterm infants. However, its application at delivery not routinely practiced in Uganda and Africa despite evidence from high income countries. Short term outcomes predictors mortality infants initiated on CPAP Delivery the St Francis hospital, Nsambya was reviewed this...
<title>Abstract</title> <bold>Background</bold>: To address the threat of retinopathy prematurity (ROP) in Sub-Saharan Africa (SSA), Stop Infant Blindness (SIBA) project introduced a comprehensive program, including subspecialty training and oxygen management equipment. <bold>Methods:</bold> A before-and-after retrospective cohort study compared preterm infants <1750g or <34 weeks’ gestation before (2022) after (2023) program implementation. Outcomes included: proportion with severe...
Background. Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of death and disability in term neonates despite therapeutic hypothermia. Hyperglycaemia the first 12 hours life is associated with poor outcomes some studies. This relationship has not yet been explored South African (SA) cohorts. Objective. To describe association between hyperglycaemia (in life) outcome, which was defined as or severely abnormal amplitude-integrated electroencephalogram (aEEG) at 48 hours,...
Abstract Background Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause newborn admissions and mortality in resource-limited settings, the contribution abnormal levels maternal and/or blood risk outcome requires elucidation. We aim determine relationship between serum cord septicemia. Methods This will be mother-newborn pair cohort study. Approximately 353 pregnant women who are eligible consent participate...
To assess the impact of secondary and tertiary level neonatal interventions on mortality over a period 11 years.Interrupted time series analysis.Nsambya Hospital, Uganda.Neonatal (phase I, 2007-2014) II, 2015-2020).Neonates.Primary outcome: mortality.case fatality rate (CFR) for prematurity, sepsis asphyxia.During study period, total 25 316 neonates were admitted, which 1853 (7.3%) died. The average inpatient reduced from 8.2% during phase I to 5.7% II (p=0.001). CFR prematurity 16.2% 9.2%...
BackgroundEvery year, an estimated 2·7 million neonatal deaths and stillbirths occur worldwide. Neonatal mortality in Uganda has been 27 per 1000 births between 2008 2018, despite increase the rate of institutional deliveries from 59% to 74% over this time. Suboptimal care still occurs hospitals, resulting maternal morbidity. Globally, perinatal death audit shown reduce by 30%. However, there is paucity data on effect outcomes Uganda. Here, we describe after introduction a tertiary hospital...