A5089195721- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- Pregnancy and preeclampsia studies
- HIV Research and Treatment
- Child Nutrition and Water Access
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- HIV/AIDS Impact and Responses
- Cervical Cancer and HPV Research
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Viral-associated cancers and disorders
- Delphi Technique in Research
- Neonatal skin health care
- Pregnancy and Medication Impact
- Emergency and Acute Care Studies
- Food Security and Health in Diverse Populations
- Maternal and Neonatal Healthcare
- Cytomegalovirus and herpesvirus research
Uganda Martyrs University
2025
Nsambya Hospital
2008-2024
Uganda Blood Transfusion Service
2003-2021
National University of Singapore
2018
University College London
2018
Medical Research Council
2018
Ministry of Health
2005-2014
Uganda Christian University
2011-2014
University of London
2014
Naggalama Hospital
2011
Abstract Hypertensive disorders of pregnancy (HDP) are the most common causes maternal and perinatal morbidity mortality. They responsible for 16% deaths in high‐income countries approximately 25% low‐ middle‐income countries. The impact HDP can be lifelong as they a recognized risk factor future cardiovascular disease. During pregnancy, system undergoes significant adaptive changes that ensure adequate uteroplacental blood flow exchange oxygen nutrients to nurture accommodate developing...
We studied the seroprevalence and transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), among 215 Ugandan children, adolescents young adults. measured antibodies to a latent nuclear antigen (LANA) lytic cycle protein encoded by open reading frame (orf) 65. Infection with KSHV/HHV8 occurred during early childhood reached adult levels (approx. 50%) before age puberty. In children younger than 12 years age, LANA orf65 were independently associated hepatitis B infection (p <...
Oxidative stress plays a role in the pathogenesis of pre-eclampsia. Supplementing women with antioxidants during pregnancy may reduce oxidative and thereby prevent or delay onset The objective this study was to evaluate effect supplementing vitamin C on incidence pre-eclampsia, at Mulago hospital, Kampala, Uganda.This (parallel, balanced randomization, 1:1) placebo randomized controlled trial conducted Department Obstetrics Gynecology. Participants included were pregnant aged 15-42 years,...
Abstract The presence of several infections was determined in tissue and serum samples from 34 cases 23 controls seen 1984–85 at Mulago Hospital Kampala, Uganda. When assessing single infections, association with cervical cancer could be shown for 5 agents, namely by Southern blot assay human papillomavirus types 16 18 (HPV), serological tests varying levels antibody titres, herpes simplex virus type 1 and/or 2 (HSV), cytomegalovirus (CMV), Epstein‐Barr virus, viral capsid antigen (EBV‐VCA),...
Abstract Background. For every maternal death, there are probably 100 or more morbidities, but the quality of health care for these women who survive has rarely been an issue. The purpose this study is to explore audit severe obstetric morbidity and concept near miss in four referral hospitals Uganda. Methods. This was exploratory systematic enquiry into a subset with designated as cases by organ failure dysfunction. Patient factors environmental were also explored. Data abstracted from...
Abstract A retrospective survey to estimate the prevalence of hepatitis B (HBV) and C (HCV) infections was conducted on samples 247 African HIV‐1 positive pregnant women who had participated a mother‐to‐child prevention trial carried out in urban settings Kampala, Uganda Kigali, Rwanda. Hepatitis markers studied were HBs antigen (HBsAg) and, if after confirmatory testing, HBe antigen/anti‐HBe antibodies HBV DNA. fourth generation HCV enzyme immunoassay (EIA) used for primary screening....
BackgroundHuman immunodeficiency virus (HIV)–infected pregnant women are at increased risk of malaria and its complications. In vitro in vivo data suggest that the HIV protease inhibitors lopinavir/ritonavir may have potent antimalarial activity. We sought to evaluate whether lopinavir/ritonavir-based antiretroviral therapy (ART) reduced placental malaria.
The aim of the study was to determine prevalence neonatal hypothermia and associated risk factors. A cross sectional, descriptive performed on 300 newborns consecutively recruited day night during 2 months at a Ugandan periurban hospital. Parallel tympanic rectal temperature measurements were made 10, 30, 60, 90 min post partum. Rectal temperatures taken showed that 29, 82, 83, 79 per cent newborns, respectively, hypothermic. Newborns observed have no body contact with mother comprised 87...
To report the experience of health workers who had played key roles in early stages implementing prevention mother-to-child HIV transmission services (PMTCT) Uganda.Interviews were conducted with 15 informants including counsellors, obstetricians and PMTCT coordinators at five test sites Uganda to investigate benefits, challenges sustainability programme. Audio-taped interviews held each informant between January June 2003. These transcribed verbatim manually analysed using framework...
Abstract Objective Pre‐eclampsia contributes significantly to maternal, foetal and neonatal morbidity mortality. The risk factors for pre‐eclampsia have not been well documented in Uganda. In this paper, we describe the women attending antenatal clinics at Mulago Hospital, Kampala. Methods This casecontrol study was conducted from 1st May 2008 2009. 207 with were cases, 352 normal pregnancy controls. 15–39 years old, their gestational ages 20 weeks or more. They interviewed about...
East Africa has experienced a rapid expansion in access to antiretroviral therapy (ART) for HIV-infected patients. Regionally representative socio-demographic, laboratory and clinical characteristics of patients accessing ART over time across sites have not been well described.We conducted cross-sectional analysis adults initiating between 2002 2009 Kenya, Uganda Tanzania the International Epidemiologic Databases Evaluate AIDS Consortium. Characteristics associated with advanced disease...
Abstract Aim: To elucidate the impact of bathing on prevalence hypothermia among newborn babies exposed to skin‐to‐skin (STS) care technique before and after bathing. Methods: Non‐asphyxiated newborns vaginal delivery ( n =249) in a Ugandan referral hospital were consecutively enrolled randomized either at 60 min postpartum =126) or no =123). All mothers practised their newborns. Four rectal tympanic registrations temperatures carried out both groups directly drying birth, 60, 70 90...
Objective: To evaluate the impact of different modalities infant feeding on HIV transmission in children a prevention mother-to-child (PMTCT) program an urban hospital Uganda. Methods: HIV-infected pregnant women PMTCT at St Francis Hospital Nsambya, Kampala were offered chance to participate study. Short-course antiretroviral regimens provided and formula free charge for choosing not breastfeed. Mother–infant pairs followed until 6 months postpartum. status was assessed week month 6. For...
Background: The perinatal mortality of 70 deaths per 1,000 total births in Uganda is unacceptably high. Perinatal death audits are important for improvement care and reduction morality. We integrated routine care, describe its effect on rate at Nsambya Hospital.Methods: This was a retrospective descriptive study conducted from March – November 2008. An interdisciplinary hospital team weekly reviews. Each case summarized discussed, identifying gaps cause death. Local solutions were...
Introduction: Pre-eclampsia, which is more prevalent in resource-limited settings, contributes significantly to maternal, fetal and neonatal morbidity mortality. However, the factors associated with these adverse outcomes are poorly understood low resource settings. In this paper we examine risk for among women pre-eclampsia at Mulago Hospital Kampala, Uganda.
Pre-eclampsia, which is more prevalent in resource-limited settings, contributes significantly to maternal, fetal and neonatal morbidity mortality. However, the factors associated with these adverse outcomes are poorly understood low resource settings. In this paper we examine risk for among women pre-eclampsia at Mulago Hospital Kampala, Uganda.
Background Quality improvement (QI) methods engage stakeholders in identifying problems, creating strategies called change ideas to address those testing and scaling them up where successful. These have rarely been used at the community level low-income country settings. Here we share experiences from rural Tanzania Uganda, QI was applied as part of Expanded Management Using Information Power (EQUIP) intervention with aim improving maternal newborn health. Village volunteers were taught how...