A5049446849- Cervical Cancer and HPV Research
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Hepatitis B Virus Studies
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- PARP inhibition in cancer therapy
- Social and Behavioral Studies
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Immunotherapy and Immune Responses
- Reproductive tract infections research
- Global Cancer Incidence and Screening
- Sarcoma Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Infrared Thermography in Medicine
- Reproductive Biology and Fertility
- Body Image and Dysmorphia Studies
- Hepatitis Viruses Studies and Epidemiology
- Erythropoietin and Anemia Treatment
- Dupuytren's Contracture and Treatments
- Ovarian function and disorders
Greater Poland Cancer Center
2021-2024
Poznan University of Medical Sciences
2008-2017
Centrum Onkologii
2017
Abstract Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported many countries following early COVID-19 pandemic response measures (‘lockdowns’). It unclear whether this variation reflects real differences lockdown impacts, or perhaps stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data 52 million births 26 countries, 18 which had representative...
Background: High-grade advanced ovarian, fallopian tube, and primary peritoneal (HGAOC) cancers require both surgical systemic treatment. The introduction of polyADP-ribose polymerase inhibitors (PARPis) has significantly improved outcomes. This study presents an analysis HGAOC patients treated at a single center, following updated guidelines. Methods: We observed 437 women newly diagnosed with the Department Gynecological Oncology between January 2018 December 2023. Results: Since November...
The prevalence and distribution of oncogenic human papillomavirus (HPV) genotypes in women who underwent screening for cervical cancer the Wielkopolska region, Poland, were assessed, correlation with histological results was evaluated. Cervical samples collected from 2969 screening. Participants screened by liquid-based cytology HPV genotyping (n = 1654) referred to colposcopy punch biopsy 616) if recommended. 16, 31, 52, 66, 53, 51 are most frequent types studied population. Genotypes 16 31...
The introduction of human papillomavirus vaccines revolutionized cervical cancer prevention. Our research hypothesis is that HPV vaccination affects the remission in swabs. We provide a prospective, ongoing, 24-month, non-randomized study HPV-positive women. enrolled 60 patients with positive swabs from cervix (fifty-one vaccinated nine-valent vaccine against and nine unvaccinated). Using an enzyme-linked immunosorbent assay, we determined IgG class antibodies patients' serums. Persistent...
We aim to describe the relationship between immunohistochemical expression patterns of HPV E4 markers and presence major capsid protein (L1) in cervical tissues obtained by biopsy patients with abnormal liquid-based cytology (LBC) results, HR infections, or clinically suspicious cervix. A novel HPV-encoded marker, SILgrade-E4 (XR-E4-1), an (clone K1H8) antibody were used demonstrate terminally differentiated epithelial cells a productive infection material. semiquantitative analysis was...
Objectives: Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. Long-term exposure to HPV a known cause squamous intraepithelial lesions that consequently lead cervical cancer development. The loop electrosurgical excision procedure (LEEP) conization an established early treatment method. We aim assess remission after LEEP in non-vaccinated patients with pre-cancerous and establish efficacy prophylaxis. Material methods: analyzed 31 conizations...
Recently, cervical cancer rates elevation has been noted in women aged 20-39 years regions with a very high human development index (HDI). The onset of is observed the age range 25-29 years, which should necessitate effective precancer screening younger groups, including those <25 years. From 30.066 liquid-based tests results (n = 30.066), 3849 cytology, 1321 high-risk papillomavirus (HRHPV) and 316 p16/Ki67 performed <30 were selected. Performance characteristics calculated for three...
The baseline data from the private-based opportunistic cervical cancer screening with HRHPV14, liquid-based cytology (LBC) and p16/Ki67 testing, its quality assessment/quality control (QA/QC) tools are lacking. age-stratified analysis of 30,066 tests results in a Polish population, including investigation HRHPV14 status, LBC, dual-staining reporting rates, along immediate histopathologic correlations, was conducted. For cytopathologic QA/QC, College American Pathologists (CAP) benchmarks...
Ovarian cancer (OC) is the eighth most common worldwide and usually diagnosed in advanced stages. Despite many available data, no treatment results have been reviewed Poland. This study enrolled 289 first-time patients treated between 2018 2021 by Department of Oncology Poznań University Medical Sciences (SKPP). The relationships among starting our centre, type first intervention, final decision were significant (p < 0.001). Patients SKPP group more likely to primarily a laparoscopy less...
Human papillomavirus (HPV) is a common sexually transmitted infection that can cause both benign and malignant lesions. HPV vaccines, preferably administered before the onset of sexual activity, have demonstrated remarkable efficacy in preventing HPV-related cancers. The impact healthcare provider's recommendation on vaccine acceptance substantial. Therefore, medical students must undergo thorough training this domain. This study compares fundamental understanding viewpoints regarding...
Human papillomavirus (HPV) is the most widespread virus with oncogenic potential that infects humans and there a need to look for effective screening method among population. Understanding role of HPV in cervical dysplasia viruses typing increased usage HPV-based cancer tests using genotyping. We aim assess usefulness Onclarity Test extended genotyping phenotyping detecting squamous intraepithelial lesions 695 subjects who registered regular or due abnormal LBC result positive results....
Abstract The optoelectronic method is one of the most promising concepts biophysical program diagnostics CIN and cervical cancer. Objectives work are evaluation sensitivity specificity in detection paper shows correlation between pNOR number sensitivity/specificity method. study included 293 patients with abnormal cytology result following examinations: examination use — Truscreen, colposcopic examination, histopathologic biopsy. Specificity for LGSIL was estimated at 65.70%, HGSIL squamous...
Aims: To search for favorable prognostic factors in CS on the basis of clinical, morphological and immunocytochemical data, while simultaneously considering histogenesis this neoplasm. Methods Results: Thirty two uterine patients were analyzed based clinical data. In addition, each specimen was immunohistochemically stained with appropriately selected antibodies characterizing relevant types cells tissues. The presence both carcinomatous sarcomatous patterns observed all tumors. Among...
To search for favourable prognostic factors in carcinosarcoma (CS) on the basis of clinical, morphological and immunocytochemical data, while simultaneously considering histogenesis this neoplasm. Thirty two uterine CS patients were analysed based clinical data. In addition, each specimen was examined by immunohistochemistry with antibodies characteristic relevant types cells tissues. The presence both carcinomatous sarcomatous patterns observed all tumours. Among patterns, endometrioid...
Vaccinations against human papillomavirus (HPV) are included in the primary prevention of precancerous intraepithelial lesions and HPV-related cancers. Despite undeniable effectiveness vaccination juvenile population, there is still little research on effect patients after sexual initiation. Our study aims to assess anti-HPV (L1 HPV) antibodies healthy diagnosed cervical pathology 9-valent vaccination. We provide a prospective, ongoing 12-month, non-randomised pilot which 89 subjects were...
Ovarian cancer (OC) is the eighth most common worldwide and usually diagnosed in advanced stages. The relationship between treatment high-volume hospitals (HVHs) survival OC has been documented by multiple studies, which showed that superior outcomes are associated with surgical expertise multidisciplinary resources. To our study, 135 first-time patients treated years 2019-2020 Department of Oncology Poznań University Medical Sciences were enrolled. Th analysis a significant dependency being...
Genitourinary tract infections in pregnant women are one of the causes abnormal pregnancy development including miscarriages, premature labor or rupture membranes (PPROM). Atypical bacteria responsible for reproductive include Mycoplasma genitalium, hominis, Ureaplasma urealyticum and parvum. Identification pathogens appropriately selected therapy can improve obstetric outcomes patients with symptoms threatened miscarriage preterm labor. The purpose our study is to analyze impact ureaplasma...
Free-of-charge vaccination against human papillomavirus (HPV-) of 12-13-year-old teenagers was introduced on the 1st June 2023 in Poland. Data baseline HPV- genotype cervical distribution are crucial to evaluate potential changes after full implementation program. We aimed at evaluating status infection and genotypes cytology gynecological patients tested one largest laboratories