A5006250205- Ovarian cancer diagnosis and treatment
- Trace Elements in Health
- Endometrial and Cervical Cancer Treatments
- Heavy Metal Exposure and Toxicity
- BRCA gene mutations in cancer
- Intraperitoneal and Appendiceal Malignancies
- Iron Metabolism and Disorders
- Social and Behavioral Studies
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Folate and B Vitamins Research
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
University of Zielona Góra
2021-2025
Poznan University of Medical Sciences
2025
Pomeranian Medical University
2024
Pathogenic mutations in BRCA1 (BReast CAncer gene 1) confer high risks of both breast (up to 70%) and ovarian 40%) cancers. Zinc (Zn) copper (Cu) are essential for various physiological functions, including antioxidant reactions. Their balance, reflected the Zn/Cu ratio, plays a crucial role maintaining redox homeostasis, which is vital cancer prevention. This study examines properties Zn Cu, specifically focusing on blood ratio as potential marker risk among mutation carriers. The cohort...
BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on carriers remains unexplored. A cohort 989 mutation underwent genetic testing at Pomeranian Medical University, Poland. Blood lead levels were measured using inductively coupled plasma mass spectrometry. Each subject was assigned to category based their...
BRCA1 mutations predispose women to breast and ovarian cancer. The anticancer effect of zinc is typically linked its antioxidant abilities protecting cells against oxidative stress. Zinc regulates key processes in cancer development, including DNA repair, gene expression, apoptosis. We took a blood sample from 989 female mutation carriers who were initially unaffected by followed them for mean 7.5 years thereafter. There 172 incident cases cancer, 121 29 cancers, 22 cancers at other sites. A...
Background: High-grade advanced ovarian, fallopian tube, and primary peritoneal (HGAOC) cancers require both surgical systemic treatment. The introduction of polyADP-ribose polymerase inhibitors (PARPis) has significantly improved outcomes. This study presents an analysis HGAOC patients treated at a single center, following updated guidelines. Methods: We observed 437 women newly diagnosed with the Department Gynecological Oncology between January 2018 December 2023. Results: Since November...
The aim of the study was to analyze frequency and magnitude association 21 recurrent founder germline mutations in BRCA1, BRCA2, PALB2, RAD51C, CHEK2 genes with ovarian cancer risk among unselected patients Poland. We genotyped BRCA1 (9 mutations), BRCA2 (4 RAD51C (3 PALB2 (2 mutations) 2270 Polish 1743 healthy controls, assessed odds ratios (OR) for developing each gene. Mutations were detected 369 out 2095 (17.6%) cases 117 (6.7%) unaffected controls. associated (OR = 40.79, 95% CI:...
Breast cancer and ovarian pose a significant risk for BRCA1 carriers, with limited risk-reduction strategies. While improved screening helps in the early detection of breast cancer, preventive measures remain elusive. Emerging evidence suggests potential link between iodine levels modulation risk, but comprehensive studies are scarce. We conducted prospective study among 989 carriers to assess association blood risk. Using inductively coupled plasma mass spectrometry, we measured observed...
Ovarian cancer (OC) is the eighth most common worldwide and usually diagnosed in advanced stages. Despite many available data, no treatment results have been reviewed Poland. This study enrolled 289 first-time patients treated between 2018 2021 by Department of Oncology Poznań University Medical Sciences (SKPP). The relationships among starting our centre, type first intervention, final decision were significant (p < 0.001). Patients SKPP group more likely to primarily a laparoscopy less...
Ovarian cancer (OC) is the eighth most common worldwide and usually diagnosed in advanced stages. The relationship between treatment high-volume hospitals (HVHs) survival OC has been documented by multiple studies, which showed that superior outcomes are associated with surgical expertise multidisciplinary resources. To our study, 135 first-time patients treated years 2019-2020 Department of Oncology Poznań University Medical Sciences were enrolled. Th analysis a significant dependency being...
<title>Abstract</title> <bold>Purpose:</bold>A large proportion of ovarian and breast cancer cases are due to genetic predisposition. Women with a mutation in the <italic>BRCA1</italic> gene have an up 80% chance developing 40% cancer. No studies date assess exposure molybdenum risk. The purpose our study was see if modifies risk carriers. <bold>Material Methods:</bold> included 989 initially unaffected women mutation. mean follow-up time 6.8 years. During this time, 172 cancers occurred...
High-grade advanced ovarian, fallopian tube and primary peritoneal (HGAOC) cancer are malignancies in which, apart from surgical treatment, systemic treatment plays an important role. The improvement results is associated with the introduction of polyADP-ribose polymerase inhibitors (PARPis). aim this study to present a cross-section patients treated for HGAOC, one center, including distribution principles following most up-to-date guidelines. We observed who reported Department...
High-grade advanced ovarian, fallopian tube and primary peritoneal (HGAOC) cancer are malignancies in which, apart from surgical treatment, systemic treatment plays an important role. The improvement results is associated with the introduction of polyADP-ribose polymerase inhibitors (PARPis). aim this study to present a cross-section patients treated for HGAOC, one center, including distribution principles following most up-to-date guidelines. We observed who reported Department...