A5027030839- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Cardiac Health and Mental Health
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cardiac Arrhythmias and Treatments
- Sexual function and dysfunction studies
- Nutrition, Genetics, and Disease
- Aluminum toxicity and tolerance in plants and animals
- Hormonal and reproductive studies
- Arsenic contamination and mitigation
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Noise Effects and Management
- Folate and B Vitamins Research
- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Pregnancy and Medication Impact
Read-Gene (Poland)
2015-2025
International Hereditary Cancer Center
2015-2024
Pomeranian Medical University
2015-2024
Central Clinical Hospital
1999-2000
Understanding of the etiology and pathogenesis pancreatic cancer (PaCa) is still insufficient. This study evaluated associations between concentrations selenium (Se) copper (Cu) in serum PaCa patients.The included 100 patients control subjects from same geographical region Poland. To determine average concentration Se, Cu, ratio Cu:Se Polish population, assay for Se Cu was performed 480 healthy individuals. Serum levels were measured using inductively coupled plasma mass spectrometry.In...
The most prevalent type of cancer among males is prostate cancer. Survival considered quite good, but it can be further improved when risk factors are optimized. One these micronutrients, including Se and Zn. To our knowledge, the interaction between Zn remains undescribed. This study aimed to investigate optimal levels selenium (Se) zinc (Zn) their impact on survival individuals diagnosed with A total 338 patients were enrolled in this study, which was conducted Poland 2009 2015. Mass...
Pathogenic mutations in BRCA1 (BReast CAncer gene 1) confer high risks of both breast (up to 70%) and ovarian 40%) cancers. Zinc (Zn) copper (Cu) are essential for various physiological functions, including antioxidant reactions. Their balance, reflected the Zn/Cu ratio, plays a crucial role maintaining redox homeostasis, which is vital cancer prevention. This study examines properties Zn Cu, specifically focusing on blood ratio as potential marker risk among mutation carriers. The cohort...
In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) prognosis of 1475 patients with four different types cancer (breast, prostate, lung larynx) from University Hospitals in Szczecin, Poland. The were taken after diagnosis prior to treatment. Patients followed date until death any cause or last follow-up (mean years follow-up: 6.0-9.8 years, according site). Kaplan-Meier curves constructed for all cancers combined each separately. Age-adjusted...
BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on carriers remains unexplored. A cohort 989 mutation underwent genetic testing at Pomeranian Medical University, Poland. Blood lead levels were measured using inductively coupled plasma mass spectrometry. Each subject was assigned to category based their...
Lung cancer is the most common adult malignancy accounting for largest proportion of related deaths. Iron (Fe) an essential trace element and a component several major metabolic pathways playing important role in many physiological processes. In this study we evaluated association between Fe concentration serum, iron metabolism parameters genetic variaton 7 genes involved anti-oxidative processes with incidence lung Poland.The included 200 patients matched healthy control subjects. We...
Early identification of women at risk developing pregnancy-induced hypertension (PIH) is very important. The involvement copper (Cu) and zinc (Zn) in the oxidative balance suggests possibility their association with this disease, which stress plays a key role. However, it has not been established so far whether microelement levels early pregnancy may be markers as prospective studies are limited number. In our innovative single-center study, we identified from cohort healthy 10–14th week...
We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage cancer. measured among 205 patients matched controls. Cases controls sex, age smoking history (total pack-years, years since cessation former smokers). The odds ratio those highest quartile level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01–9.67, p < 0.01). association present smokers 16.8, CI:3.96−71.2, 0.01), but not current...
There is a need for sensitive and specific biomarkers the early detection of colorectal cancer. In this retrospective study, we assessed whether high blood copper level was associated with presence The measured among 187 cancer patients matched controls. Cases controls were sex, smoking status (yes/no) year birth. Among cases, mean 1031 µg/L (range 657 to 2043 µg/L) controls, 864 589 1433 µg/L). odds ratio those in highest quartile (versus lowest) 12.7 (95% CI: 4.98-32.3; p < 0.001). Of...
The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data the these elements survival. In this research, we examined whether blood concentrations arsenic, cadmium, mercury and lead were associated with overall survival lung patients. study group consisted 336 patients who prospectively observed. Blood measured to relationship between their levels using Cox proportional hazards analysis. hazard ratio death from all causes was 0.99 (p =...
BRCA1 mutations predispose women to breast and ovarian cancer. The anticancer effect of zinc is typically linked its antioxidant abilities protecting cells against oxidative stress. Zinc regulates key processes in cancer development, including DNA repair, gene expression, apoptosis. We took a blood sample from 989 female mutation carriers who were initially unaffected by followed them for mean 7.5 years thereafter. There 172 incident cases cancer, 121 29 cancers, 22 cancers at other sites. A...
Background: The pathogenesis of psoriasis is poorly understood. Increased reactive oxygen species (ROS) and lipid peroxidation are crucial in the inflammatory processes, including psoriasis. Thus, microelements, such as zinc copper, may play a significant role this disease's development. Methods: Due to paucity inconsistency literature data, we studied levels copper blood serum from 301 unselected psoriatic patients matched healthy controls examined any associations among microelements...
Among patients treated with neoadjuvant chemotherapy (NAC), a high survival rate is observed for those who experience pathological complete response (pCR). Various tumor factors are predictive of pCR, but few host have been studied.We sought to inquire whether or not patient's blood selenium level prior treatment was pCR. We studied 329 women diagnosed primary invasive breast cancer were (NAC). included HER2-positive (n = 183) triple-negative 146). Blood collected before the initiation...
Background/Objectives: Copper (Cu) and zinc (Zn) are essential trace elements, an imbalance in their levels may influence the progression of cancer. The role Cu Zn blood serum, as well 10-year survival rates kidney cancer patients, remains unclear. Our objective was to determine association between these micronutrients mortality patients. In this prospective study, we examined 284 consecutive, unselected patients assessed relation levels. Methods: Micronutrient were measured using...
Background: In addition to a beneficial effect on exercise tolerance and an associated reduction of global cardiovascular risk, modificationof physical activity has positive the quality life, reducing, among other things, severity erectile dysfunction (ED). Aim: The specific nature sexual activity, which combines need maintain appropriate good erection quality, prompted us evaluate association between ED in intervention group subjectswith ischaemic heart disease (IHD) context cardiac...
Introduction Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported literature suggests that zinc may be related to prostate cancer. In this study we evaluated association serum levels and polymorphisms genes encoding zinc-dependent proteins with Poland. Methods The group consisted 197 affected healthy men. Serum were measured 5 single nucleotide MMP-1, MMP-2, MMP-7, MMP-13, MT2A genotyped. Results mean level was higher patients...
Background Observational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, impact low serum level on survival has not been evaluated. Methods We conducted a prospective study 296 patients diagnosed with cancer in Szczecin, Poland. Serum was measured at diagnosis prior to treatment. Patients were followed from date death five years. Vital obtained by linkage Polish National Death Registry. Results The five-year...
Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research focused on effect of in populations with endemic exposure, levels within normal limits. We sought to determine if blood predict other cancers among women northern Poland. The cohort consisted 1,702 healthy women, aged 40 above, identified 2010 2017. Blood level was determined by inductively coupled plasma mass...
In a recent prospective study, we reported an association between low serum selenium level and five-year survival among breast cancer patients. We now have updated the cohort to include 10-year rates. A blood sample was obtained from 538 women diagnosed with first primary invasive 2008 2015 in region of Szczecin, Poland. Blood collected before initiation treatment. Serum levels were quantified by mass spectroscopy. Each patient assigned one four quartiles based on distribution whole cohort....
There is emerging interest in the relationship between several serum micronutrients and prognosis of patients with breast cancer. The zinc copper levels cancer unclear. In our study, we included 583 diagnosed 2008 2015 region Szczecin, Poland. a blood sample obtained before treatment, were quantified by mass spectroscopy. Each patient was assigned to one four categories (quartiles) based on distribution elements entire cohort. Patients followed from diagnosis death over mean 10.0 years....
Cadmium (Cd) is a known carcinogen, but its impact on cancer risk at lower concentrations poorly understood. Previous studies Cd and in men show inconsistent results, prompting further investigation. A prospective cohort study involving 2956 was conducted. Blood levels were measured, participants followed for 78 months to assess incidence. Men with high blood (>0.71 µg/L) had significantly increased of compared those low (<0.19 (HR 3.42, p < 0.001), particularly among non-smokers...
Abstract Background Epidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low levels. It is of interest to prospectively evaluate the women who reside in region ubiquitously Methods We performed nested case-control study baseline serum levels using data biological samples from 19,573 females that were participants biobanking initiative 2010 2014 Szczecin Poland. Cases included any incident ( n = 97) controls 184) no at or follow-up....
Abstract Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens an important lung cancer. One these substances chromium, which found ubiquitously across planet. The International Agency for Research on Cancer has classified chromium(VI) as a human carcinogen. aim this study was assess whether serum chromium levels, well DNA variants in selected genes involved carcinogenesis, xenobiotic-metabolism, oxidative stress could be...