A5081471988- Asthma and respiratory diseases
- Nonmelanoma Skin Cancer Studies
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Geriatric Care and Nursing Homes
- Pediatric health and respiratory diseases
- Homelessness and Social Issues
- Child and Adolescent Health
- Intergenerational Family Dynamics and Caregiving
- Tendon Structure and Treatment
- Emergency and Acute Care Studies
- Eosinophilic Esophagitis
- Pelvic and Acetabular Injuries
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Food Security and Health in Diverse Populations
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Enzyme Structure and Function
Royal National Orthopaedic Hospital
2003-2024
University College London
2003-2024
Royal National Orthopaedic Hospital NHS Trust
2004-2024
Salford Royal NHS Foundation Trust
2015-2023
University of Manchester
2021-2023
Glenfield Hospital
2010-2019
University Hospitals of Leicester NHS Trust
2013-2017
University of Leicester
2010-2017
NIHR Leicester Respiratory Biomedical Research Unit
2013
University of Alberta
1992-2011
The relationship between airway inflammation and obesity in severe asthma is poorly understood.We sought to determine the sputum mediator profiles distribution of eosinophilic people with asthma.Clinical parameters eight mediators were assessed 131 subjects from a single center categorized into lean, overweight, obese groups defined by their body mass index. In an independent group (n = 45) healthy control 19) was enumerated bronchial submucosa, blood, related index.Sputum IL-5 geometric...
Genetic screening of the breast and ovarian cancer susceptibility gene BRCA1 has uncovered a large number variants uncertain clinical significance. Here, we use biochemical cell-based transcriptional assays to assess structural functional defects associated with set 117 distinct missense within essential BRCT domain protein that have been documented in individuals family history or cancer. In first method, used limited proteolysis folding stability each mutants compared wild-type. second...
The BRCA1 BRCT domain binds pSer-x-x-Phe motifs in partner proteins to regulate the cellular response DNA damage. Approximately 120 distinct missense variants have been identified through breast cancer screening, and several of these linked an increased risk. Here we probe structures peptide-binding activities that affect phosphopeptide-binding groove. results obtained from G1656D T1700A illustrate role Ser1655 pSer recognition. Mutations at Arg1699 (R1699W R1699Q) significantly reduce...
Abstract Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in large animal model naturally-occurring similar to human has shown benefits autologous bone marrow-derived mesenchymal stem cell (MSC) implantation. However, MSCs are advanced therapies medicinal products (ATMPs), with strict regulatory requirements. Guided by the regulator we carried out first man study assess safety and efficacy MSC injection patients non-insertional...
Rationale: Pulmonary rehabilitation (PR) in patients with COPD has consistently been shown to produce benefits exercise capacity, symptoms, and health status. The data surrounding survival following PR are less clear. Our aims were compare the long-term two cohorts of referred for PR; those who successfully completed PR, a comparator group constructed from either did not complete or start program. Additionally, we compared between people able achieve clinically meaningful improvement...
Polynucleotide kinase/phosphatase (PNKP) is a critical mammalian DNA repair enzyme that generates 5′-phosphate and 3′-hydroxyl groups at damaged termini are required for subsequent processing by ligases polymerases. The PNKP phosphatase domain recognizes 3′-phosphate within nicks, gaps, or double- single-strand breaks. Here we present mechanistic rationale the recognition of domain. crystal structures bound to single-stranded substrates reveals narrow active site cleft accommodates substrate...
S ummary . Forty‐eight subjects (16–17 years old), randomly assigned to two recall conditions (immediate and delayed), were each given prose passages recall, one after reading, the other listening. The judged be difficult in content unfamiliar. An incidental procedure was adopted. Following Meyer's (1975) analytic procedures, protocols scored for presence of idea units, relationship units number at level structure. Number errors independently scheme. As hypothesised a task involving...
Study Design. Prosepective study of cervical spine magnetic resonance imaging. Objectives. To determine the frequency nonvisualization spinal ligaments in patients who have not suffered acute trauma. Summary Background Data. The appear on studies as a thin hypointense line, "black stripe." Discontinuity this stripe" is considered reliable sign ligament rupture following Methods. Twenty (13 female and 7 male, mean age 45.5 years, range 28–58 years) undergoing imaging for degenerative disc...
Cancer susceptibility and mortality are higher in males, the mutational transcriptomic landscape of cancer differs by sex. The current assumption is that men at risk epithelial cancers as they expose more to carcinogens accumulate damage than women. We present data showing women with less aggressive primary cutaneous squamous cell carcinoma (cSCC) early strong immune activation.We explored clinical molecular sexual disparity immunocompetent immunosuppressed patients cSCC (N = 738, N 160),...
Abstract: It is increasingly recognized that large proportions of patients with asthma remain poorly controlled daily symptoms, limitation in activities, or severe exacerbations despite traditional treatment inhaled corticosteroids and other agents. This suggests there considerable scope for the refinement guidelines on use therapies also a need development novel therapeutic agents, particularly asthma. review aims to discuss range emerging approaches Firstly, we will set scene by...
Homeless people need emotional support, caring professionals, and resources that work within their frame of reality. Each homeless community will have different demographics health needs. The common denominators are the obstacles encountered when trying to access care: bureaucracy, transportation, accessibility, present-time orientation, limited resources, frustration, anxiety. Nurse-managed free clinics an effective means serving needs indigent populations. Through these clinics, clients...
Achilles tendinopathy (AT) is a cause of pain and disability affecting both athletes sedentary individuals. More than 150 000 people in the UK every year suffer from AT.While there much preclinical work on use stem cells tendon pathology, scarcity clinical data looking at mesenchymal to treat disease does not appear be any studies autologous cultured (MSCs) for AT. Our hypothesis that culture expanded MSCs implanted into an area mid-portion AT will lead improved pain-free mechanical...
More needs to be done help overseas doctors adapt their new working life, say Irene Valero-Sanchez and colleagues
Pulmonary rehabilitation with core components of exercise training and multiprofessional education is an integral part the management patients chronic lung disease. International guidelines for individuals asthma recommend as improves symptoms, indices cardiopulmonary efficiency, health status psychosocial outcome. However, there little published evidence evaluating safety acceptability severe are concerns regarding exercise-induced asthma. We propose a feasibility study multicentre...