A5053363378- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Thyroid Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Indoor Air Quality and Microbial Exposure
- Opioid Use Disorder Treatment
- Antibiotic Resistance in Bacteria
- Veterinary medicine and infectious diseases
Flevoziekenhuis
2016-2024
Amsterdam University Medical Centers
2019-2024
University of Amsterdam
2013-2024
Cancer Center Amsterdam
2023
De Kinderkliniek
2021
Amsterdam UMC Location University of Amsterdam
2004-2019
Worcestershire Royal Hospital
2010
Lindenhofspital
2008
Tergooi
2007
University of Bath
2001
ABSTRACT Although the high mortality rate of pulmonary invasive aspergillosis (IA) in patients with prolonged chemotherapy-induced neutropenia (PCIN) can be reduced by timely diagnosis, a diagnostic test that reliably detects IA at an early stage is lacking. We hypothesized electronic nose (eNose) could fulfill this need. An eNose discriminate various lung diseases through analysis exhaled volatile organic compounds (VOCs). cheap and noninvasive yields results within minutes. In...
Background Oncokompas is a web-based self-management application that supports cancer survivors to monitor their health-related quality of life (HRQOL) and symptoms, obtain personalised feedback tailored options for supportive care. In large randomised controlled trial among head neck cancer, colorectal breast (non-)Hodgkin lymphoma, proved improve HRQOL, reduce several tumour-specific symptoms. Effect sizes were however small, no effect was observed on the primary outcome patient...
Abstract Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation macrophage‐, dendritic cell‐, or monocyte‐differentiated cells in various tissues and organs. The discovery recurrent genetic alterations many these histiocytoses has led to their recognition as clonal neoplastic diseases. Moreover, identification same somatic mutation histiocytic lesions peripheral blood and/or bone marrow from histiocytosis patients provided evidence for systemic neoplasms...
Currently, there is no noninvasive test that can reliably diagnose early invasive pulmonary aspergillosis (IA). An electronic nose (eNose) discriminate various lung diseases through an analysis of exhaled volatile organic compounds. We recently published a proof-of-principle study showing patients with prolonged chemotherapy-induced neutropenia and IA have distinct breath profile (or breathprint) be discriminated eNose. eNose cheap noninvasive, it yields results within minutes. determined...
Abstract Purpose The eHealth self-management application ‘Oncokompas’ was developed to support cancer survivors in monitoring health-related quality of life (HRQOL) and symptoms, obtaining personalized feedback options for supportive care. aim this study assess the cost-utility Oncokompas compared with care as usual (CAU) among survivors. Methods Survivors were randomly allocated intervention or control group. Direct (non-)medical, indirect non-medical costs, HRQOL measured at 3- 6-month...
Abstract Patients with high-grade B-cell lymphoma MYC and BCL2 rearrangements (HGBL-MYC/BCL2) respond poorly to immunochemotherapy compared patients diffuse large not otherwise specified (DLBCL NOS) without a rearrangement. This suggests negative impact of lymphoma-intrinsic on the immune system. To investigate this, we circulating T cells natural killer (NK) HGBL-MYC/BCL2 (n = 66), DLBCL NOS 53), age-matched healthy donors (HDs; n 16) by flow cytometry performed proliferation, cytokine...
In 2015, the International Myeloma Working Group (IMWG) introduced a frailty index (IMWG-FI), as means to quantify fragility of patients with multiple myeloma (MM). This categorizes into three groups: fit, intermediate-fit, or frail, based on age, comorbidities, and level assistance for (instrumental) daily activities ((i)ADL). Scores IMWG-FI range from zero five points. A score designates one indicates between two denotes frail. Three-year overall survival rates were 84% in fit patients,...
With the combined peri- and intravascular sclerosing technique esophageal varices can be completely eliminated in an average of three treatment sessions. In order to check success procedure, endoscopic histological findings at various stages after with 1% Polidocanol were compared. Clinical autopsy are agreement. After sclerosing, necroses mucosa intramural inflammations occur regularly first week. The thrombosed. Later, inner wall esophagus is cicatricially changed. Histologically fibroses...
The web-based self-management application Oncokompas was developed to support cancer survivors monitor health-related quality of life and symptoms (Measure) provide tailored information (Learn) supportive care options (Act). In a previously reported randomised controlled trial (RCT), 68% 655 recruited were eligible, those 45% participated in the RCT. Among participants RCT that intervention group, 52% used as intended. aim this study explore reasons for not participating RCT, using among...
Abstract Introduction In anti-myelin-associated glycoprotein IgM paraprotein-related peripheral neuropathy (anti-MAG PN), there is a lack of reliable biomarkers to select patients eligible for therapy and evaluating treatment effects, both in routine practice clinical trials. Neurofilament light chain (NfL) contactin-1 (CNTN1) can serve as markers axonal paranodal damage. Complement activation involved the pathogenesis anti-MAG PN. We, therefore, hypothesized that serum NfL, CNTN1, C3b/c...
Invasive pulmonary mold disease (IPMD) is often fatal in neutropenic patients. This because IPMD difficult to diagnose timely, especially when non-Aspergillus molds are the causative agent, as they usually not associated with a positive galactomannan assay. In 2013 we showed that exhaled breath analysis might be used invasive aspergillosis through profiling of patterns volatile organic compounds (VOCs) by electronic nose (eNose) technology. The current study aimed determine (1) whether can...
Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by vitro cultured, clinical Aspergillus isolates using gas chromatography–mass spectrometry (GC-MS). Three and a reference strain were cultured while conidiation was prevented. Headspace samples analyzed standardized method. Breath patients from which cultures obtained checked for VOCs found vitro. Each isolate produced distinct profile....
Intravenous fluid therapy (IV-FT) is routinely used in the treatment of vaso-occlusive crises (VOCs), as dehydration possibly promotes and sustains erythrocyte sickling. Patients with sickle cell disease (SCD) are at risk developing diastolic dysfunction overload due to IV-FT. However, data on adverse effects IV-FT for VOC sparse. We aimed evaluate incidence factors patients SCD. Consecutive hospitalisations treated between September 2016 2018 were retrospectively analysed. The median...
Patients with Chronic Lymphocytic Leukemia (CLL) have a 29- to 36-fold increased risk of invasive pneumococcal disease (IPD) compared healthy adults. Therefore, most guidelines recommend vaccination the 13-valent conjugated vaccine (PCV13) followed 2 months later by 23-valent polysaccharide (PPSV23). Because both CLL as well immunosuppressive treatment been identified major determinants immunogenicity, we aimed assess schedule in untreated and treated patients. We quantified IgG...