A5053851384- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Kruppel-like factors research
- Chronic Myeloid Leukemia Treatments
- Intestinal and Peritoneal Adhesions
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- AI in cancer detection
- Autoimmune and Inflammatory Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- biodegradable polymer synthesis and properties
- Colorectal Cancer Surgical Treatments
- Acute Lymphoblastic Leukemia research
- Hemostasis and retained surgical items
Erasmus MC Cancer Institute
2018-2025
Erasmus MC
2014-2024
Wan Fang Hospital
2024
Taipei Medical University
2024
Chung Shan Medical University Hospital
2024
Chinese University of Hong Kong
2024
University of Hong Kong
1995-2024
Erasmus University Rotterdam
2013-2023
European Space Research and Technology Centre
2023
Princess Máxima Center
2022
In the new WHO-European Organisation for Research and Treatment of Cancer (WHO-EORTC) classification cutaneous lymphomas three major groups primary B-cell lymphoma (CBCL) are distinguished: marginal zone (PCMZL) follicle center (PCFCL) with a good prognosis, large lymphoma, leg type (PCLBCL-LT), an intermediate-level prognosis. This study aimed to assess clinical significance compared previous schemes (EORTC 1997; WHO 2001) define prognostic factors within newly defined categories.In present...
Functional contributions of individual cellular components the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed generate a comprehensive map stroma MPNs/MFs on single-cell level murine models and patient samples. Our analysis revealed two distinct mesenchymal stromal cell (MSC) subsets as pro-fibrotic cells. MSCs were functionally reprogrammed stage-dependent manner loss their progenitor status...
Recent observations of abnormal immunoglobulin responses and case reports describing successful B-cell ablative therapy suggest involvement B cells in the pathogenesis sarcoidosis.To investigate how maturation function patients with sarcoidosis contribute to disease.Patients (n = 32) were included for detailed analysis by immunohistochemistry tissue, flow cytometry blood subsets, serum levels. Vaccination influenza virus encapsulated bacteria molecular heavy chain transcripts studied...
Immunochemotherapy with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) has become standard of care for patients diffuse large B-cell lymphoma (DLBCL). This randomized trial assessed whether intensification during the first 4 cycles R-CHOP could improve outcome these compared R-CHOP.A total 574 DLBCL age 18 to 80 years were randomly assigned induction therapy 6 or 8 R-CHOP-14 (RR-CHOP-14) without (R-CHOP-14) in cycles. The primary end point was complete...
Abstract Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation macrophage‐, dendritic cell‐, or monocyte‐differentiated cells in various tissues and organs. The discovery recurrent genetic alterations many these histiocytoses has led to their recognition as clonal neoplastic diseases. Moreover, identification same somatic mutation histiocytic lesions peripheral blood and/or bone marrow from histiocytosis patients provided evidence for systemic neoplasms...
Bone marrow formation requires an orchestrated interplay between osteogenesis, angiogenesis, and hematopoiesis that is thought to be mediated by endothelial cells. The nature of the cells molecular mechanisms underlying these events remain unclear in humans. Here, we identify a subset endoglin-expressing enriched human bone during fetal ontogeny upon regeneration after chemotherapeutic injury. Comprehensive transcriptional characterization massive parallel RNA sequencing reveals phenotypic...
B-cell depletion can improve a variety of chronic inflammatory diseases, but does not appear beneficial for patients with Crohn's disease.To elucidate the involvement B cells in disease, we here performed an 'in depth' analysis intestinal and blood B-cells this disease.Patients disease were recruited to study infiltrates biopsies (n = 5), serum immunoglobulin levels phenotype molecular characteristics subsets 21). The effects infliximab treatment studied 9 patients.Granulomatous tissue...
With tumor genomic and gene-expression profiling (GEP), this study investigated the immune-molecular signatures of a unique cohort diffuse large B-cell lymphoma bone (bone-DLBCL), including primary (PB-DLBCL, n = 52) polyostotic-DLBCL (n 20), in comparison to nodal DLBCLs with germinal center (GCB) phenotype (nodal-DLBCL-GCB, 34). PB-DLBCL shared similar profiles transcriptomic signatures, justifying their collective analysis as bone-DLBCL. Differential incidences EZH2, HIST1H1E, MYC...
Abstract A chromosomal translocation involving the MYC gene is characteristic of Burkitt lymphoma (BL) and represents a molecular disease marker with diagnostic clinical implications. The detection breakpoints hampered by technical problems, including distribution over very large genomic region approximately 1,000 kb. In this article, we report on testing validation segregation fluorescence in situ hybridization (FISH) assay for series BLs. contig overlapping clones was generated, two probe...
Hydroxyethyl starch (HES) solutions have largely replaced conventional plasma expanders such as human albumin and colloidal fluids. Only a few side effects been reported mainly concern pruritus or blood coagulation disorders. Excessive HES exposure can result in diffuse tissue storage accumulation with foamy appearing macrophages which produce the enzyme chitotriosidase (CT). In case of massive storage, this activity reach levels comparable to those Gaucher disease.In single-center...
Using two distinct anti-CB2 receptor Abs, we investigated the expression patterns of peripheral cannabinoid CB2 in human secondary lymphoid organs. Immunohistochemical analysis using an N-terminal specific Ab revealed high protein germinal centers (GCs) follicles. A C-terminal Ab, which only recognizes a nonphosphorylated inactive receptor, showed positivity mantle zones (MZs) and marginal (MGZs) follicles where resting cells reside, primary In contrast, no was observed GCs suggesting that...
Early phases of polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF) can be difficult to distinguish by morphologic studies alone because they share many characteristics. Histologic criteria according the 2008 World Health Organization (WHO) classification are part myeloproliferative neoplasia (MPN) diagnosis. Our aim was assess reproducibility characteristics determine their relative importance for histologic diagnoses on selected trephine biopsy sections. For...
Migraine-like cerebral transient ischemic attacks (MIAs) and ocular manifestations were the main presenting features in 10 JAK2<sup>V617F</sup>-positive patients studied, with essential thrombocythemia (ET) 6 polycythemia vera (PV) 4. Symptoms varied included attacks, mental concentration disturbances followed by throbbing headaches, nausea, vomiting, syncope or even seizures. MIAs frequently preceded events of blurred vision, scotomas, flashing eyes, sudden partial blindness...
Many hyperplasias and lymphomas of marginal zone B-cells are associated with infection. We identified six children one adolescent cervical lymphadenopathy showing prominent polyclonal nodal hyperplasia (pNMZH) four adolescents monoclonal paediatric lymphoma (pNMZL). The clonality status was assessed using BIOMED-2-IG PCR analysis. Haemophilus influenzae in all cases pNMZH that could be tested by direct culture (N = 3) or a very sensitive for the H. gyrase gene frozen materials 5). not...
Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis.We first performed colectomy 7 days 10 mg trinitrobenzene sulfonic acid (TNBS)-induced colitis validate rat TNBS-colitis-colectomy model. Subsequently, this model was used in 73 Wistar...
It is unclear whether survival in diffuse large B-cell lymphoma (DLBCL) continues to increase an era where rituximab-containing chemotherapy reigns for almost two decades. Therefore, we evaluated trends primary therapy and relative (RS) among Dutch DLBCL patients diagnosed between 1989 2018. Analyses were performed separately according the stage I (N = 6952) II-IV disease 20,676), stratified by calendar period age (18-64, 65-74, ≥75 years). The use of ± radiotherapy increased over time...