A5002072156- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Nonmelanoma Skin Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cutaneous lymphoproliferative disorders research
- Cancer-related Molecular Pathways
- AI in cancer detection
- Ovarian cancer diagnosis and treatment
- Cell Adhesion Molecules Research
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cell Image Analysis Techniques
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
McGill University
2016-2025
Jewish General Hospital
2016-2025
McGill University Health Centre
2018-2025
Centre Léon Bérard
2024
GTx (United States)
2023
Jewish Hospital
2017-2022
Dalhousie University
2019
University Health Network
2019
University of Toronto
2019
Health Center
2019
BACKGROUND: DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability safety first Phase I clinical trial using autologous exosomes pulsed with MAGE 3 peptides for immunization stage III/IV melanoma patients. Secondary endpoints were monitoring outcome. PATIENTS AND METHODS: Exosomes purified from day 7 monocyte derived-DC cultures. Fifteen patients fullfilling...
Gene expression profiling data for human primary cutaneous melanomas are scarce because of the lack retrospective collections frozen tumors. To identify differentially expressed genes that may be involved in melanoma progression and prognosis, we investigated relationship between gene profiles clinical outcome a cohort patients with melanoma.Labeled complementary RNA (cRNA) from each tissue sample was hybridized to pangenomic 44K 60-mer oligonucleotide microarray. Class comparison class...
Purpose Adjuvant pegylated interferon alfa-2b (PEG-IFN-α-2b) was approved for treatment of resected stage III melanoma in 2011. Here, we present long-term follow-up results this pivotal trial. Patients and Methods In all, 1,256 patients with were randomly assigned to observation (n = 629) or PEG-IFN-α-2b 627) an intended duration 5 years. Stratification factors microscopic (N1) versus macroscopic (N2) nodal involvement, number positive nodes, ulceration tumor thickness, sex, center....
Active immunization against the tumor-specific MAGE-A3 antigen is followed by a few but impressive and durable clinical responses. This randomized phase II trial evaluated two different immunostimulants combined with protein to investigate whether more robust persistent immune response could be associated increased benefit.Patients MAGE-A3-positive stage III or IV M1a melanoma were randomly assigned receive either AS02B AS15 immunostimulant. Clinical end points toxicity rates of objective...
Melanoma is an immunogenic cancer with a high response rate to immune checkpoint inhibitors (ICIs). It harbors mutation burden compared other cancers and, as result, has abundant tumor-infiltrating lymphocytes (TILs) within its microenvironment. However, understanding the complex interplay between stroma, tumor cells, and distinct TIL subsets remains substantial challenge in oncology. To properly study this interplay, quantifying spatial relationships of multiple cell types microenvironment...
Mutant isoforms of the KIT or PDGF receptors expressed by gastrointestinal stromal tumors (GISTs) are considered therapeutic targets for STI571 (imatinib mesylate; Gleevec), a specific inhibitor these tyrosine kinase receptors. Case reports clinical efficacy Gleevec in GISTs lacking typical receptor mutations prompted search an alternate mode action. Here we show that can act on host DCs to promote NK cell activation. DC-mediated activation was triggered vitro and vivo treatment with as well...
Objectives: To provide an accurate description and to evaluate the incidence severity of cutaneous reactions induced by sorafenib tosylate, a new oral multikinase inhibitor.Design: Double-blind, prospective dermatologic substudy performed on all consecutive patients included in our center large phase 3 trial.Setting: Institutional practice at Gustave Roussy Institute.Patients: Eighty-five with renal cell cancer treated between November 1, 2003, February 28, 2005.Interventions: Patients were...
<h3>Objective</h3> To describe a grading system for risk stratification of atypical Spitz tumors in children and adolescents. In some circumstances, unequivocal distinction between nevus melanoma is practically impossible. It likely that these lesions which we lack specific diagnostic criteria represent broad histological continuum extending from benign to malignant tumors. Therefore, propose be categorized into low-, intermediate-, or high-risk categories based on the accumulation abnormal...
Purpose Prognosis in patients with sentinel node (SN) –positive melanoma correlates several characteristics of the metastases SN such as size and site. These factors reflect biologic behavior may separate out who or not need additional locoregional and/or systemic therapy. Patients Methods Between 1993 2008, 1,080 (509 women 571 men) were diagnosed tumor burden nine European Organisation for Research Treatment Cancer (EORTC) group centers. In total, 1,009 (93%) underwent completion lymph...
Abstract 1158 sentinel lymph nodes (SLNs), excised from patients with primary cutaneous melanoma, were assessed pathologically using histology immunohistochemistry (IHC) on all nodes, and RT‐PCR for Mart‐1 tyrosinase 55 nodes. was compared the IHC same The evaluation of progressively more detailed protocols modulated by results led to a procedure that consistently detects metastases in 34% submitted SLN biopsy melanomas vertical growth phase mean thickness 2.02 mm (range 0.25, regression, 19...
Melanoma is comprised of biologically distinct subtypes. The defining clinical, histomorphologic, and molecular features are not fully established. This study sought to validate the association between genetic histomorphologic previously described determine their reproducibility with important clinical variables. Detailed 365 primary cutaneous melanomas were assessed by 11 pathologists correlated mutation status BRAF NRAS. There was substantial agreement in quantitative assessment showing...