A5039504469- Angiogenesis and VEGF in Cancer
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- T-cell and Retrovirus Studies
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Lymphatic System and Diseases
John Radcliffe Hospital
2016-2025
University of Oxford
2015-2024
Cancer Research UK
2003-2014
Universidad de Navarra
2014
Consejo Superior de Investigaciones Científicas
2014
Churchill Hospital
2014
Centro Nacional de Biotecnología
2014
Nuffield Health
2014
Institute of Molecular Medicine
1994-2014
Shandong Provincial Hospital
2014
Circulating nucleic acids have been shown to potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls 43). Levels were higher patient than control sera (P 0.009, 0.02 0.04 respectively). Moreover, high expression was associated relapse-free survival...
The proto-oncogene bcl-2 encodes a protein that inhibits programmed cell death (apoptosis). is expressed in basal cells normal human epithelium, but no data are available on the frequency or clinical importance of its expression carcinoma. We studied patients with non-small-cell lung carcinoma and correlated this phenomenon survival.
Hypoxia inducible factors HIF1α and HIF2α are important proteins involved in the regulation of transcription a variety genes related to erythropoiesis, glycolysis angiogenesis. Hypoxic stimulation results rapid increase 2α protein levels, as consequence redox-sensitive stabilization. The HIFαs enter nucleus, heterodimerize with HIF1β protein, bind DNA at hypoxia response elements (HREs) target genes. In this study we evaluated immunohistochemical expression these 108 tissue samples from...
Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates, which appears be superior the tumor-node-metastasis (TNM) classification colorectal cancer. In non-small lung cancer (NSCLC), no immunoscore has been established, but tumor immunology recognized as highly important. We have previously evaluated impact of several immunological markers NSCLC, yielding density stromal CD8(+) tumor-infiltrating lymphocytes (TIL) most promising candidate. Hence, we validate TIL...
PURPOSE This study investigated the frequency of expression and prognostic significance a panel immunocytochemical markers in resected non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS A total 515 cases pathologic stage I NSCLC were analyzed. The median follow-up time surviving patients was 102 months. following tested: blood group precursors antigens; laminin receptor; c-erbB1/epidermal growth factor receptor (EGFR) c-erbB2/Neu; BCl2; p53; angiogenesis. Kaplan-Meier estimates...
It is now well established that solid tumour growth depends on angiogenesis. However, less known about the generation of new vessels in haematological malignancies and, particular, preleukaemic-myelodysplastic syndromes (MDS). In this study, bone marrow microvessel density (MVD) was assessed by immunohistochemistry and compared trephine biopsies from 14 controls, five infectious disease (ID), 82 MDS, 15 acute myeloid leukaemia (AML) myeloproliferative disorder (MPD) patients. Statistical...
Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and molecular mechanisms of their not fully delineated. The aim this study to evaluate expression HIF-related molecules in a series patients with pancreatic endocrine (PETs). vascular endothelial growth (VEGF), HIF-1alpha, HIF-2alpha carbonic anhydrase 9 (CA9) was examined immunohistochemistry 45 PETs compared microvascular density (MVD), proliferation,...
Basal-like tumours account for 15% of invasive breast carcinomas and are associated with a poorer prognosis resistance to therapy. We hypothesised that this aggressive phenotype is because an intrinsically elevated hypoxic response. Microarrayed from 188 patients were stained hypoxia-inducible factor (HIF)-1α, prolyl hydroxylase (PHD)1, PHD2, PHD3 inhibiting HIF (FIH)-1, carbonic anhydrase (CA) IX in 456 tumours. Tumour subtypes correlated standard clincopathological parameters as well...
MicroRNAs are naturally occurring small RNA species that regulate gene expression and frequently abnormally expressed in cancers. However, the role of microRNAs lymphoma is poorly understood. Therefore, we undertook a comprehensive study microRNA two most common lymphomas: diffuse large B-cell (DLBCL) (n = 80) follicular (FCL) 18) using microarrays containing probes for 464 human microRNAs. Unsupervised cluster analysis revealed distinct patterns between these lymphomas specific signatures...
Histone deacetylase (HDAC) inhibitors are emergent cancer drugs. HR23B is a candidate biomarker identified in genome-wide loss-of-function screen which influences sensitivity to HDAC inhibitors. Because have found clinical utility cutaneous T-cell lymphoma (CTCL), we evaluated the role of CTCL cells. Our results show that governs cells Furthermore, proteasome activity deregulated inhibitor-treated through mechanism dependent upon HR23B, and sensitize effects The predictive power for response...